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Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania.

Abstract

Cannabidiol (CBD), a Cannabis sativa constituent, may present a pharmacological profile similar to mood stabilizing drugs, in addition to anti-oxidative and neuroprotective properties. The present study aims to directly investigate the effects of CBD in an animal model of mania induced by D-amphetamine (D-AMPH). In the first model (reversal treatment), rats received saline or D-AMPH (2 mg/kg) once daily intraperitoneal (i.p.) for 14 days, and from the 8th to the 14th day, they were treated with saline or CBD (15, 30 or 60 mg/kg) i.p. twice a day. In the second model (prevention treatment), rats were pretreated with saline or CBD (15, 30, or 60 mg/kg) regime i.p. twice a day, and from the 8th to the 14th day, they also received saline or D-AMPH i.p. once daily. In the hippocampus CBD (15 mg/kg) reversed the d-AMPH-induced damage and increased (30 mg/kg) brain-derived neurotrophic factor (BDNF) expression. In the second experiment, CBD (30 or 60 mg/kg) prevented the D-AMPH-induced formation of carbonyl group in the prefrontal cortex. In the hippocampus and striatum the D-AMPH-induced damage was prevented by CBD (15, 30 or 60 mg/kg). At both treatments CBD did not present any effect against d-AMPH-induced hyperactivity. In conclusion, we could not observe effects on locomotion, but CBD protect against d-AMPH-induced oxidative protein damage and increased BDNF levels in the reversal model and these effects vary depending on the brain regions evaluated and doses of CBD administered.

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  • Authors+Show Affiliations

    ,

    Laboratório de Neurociências, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brasil.

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    Source

    MeSH

    Amphetamine
    Animals
    Antimanic Agents
    Bipolar Disorder
    Brain-Derived Neurotrophic Factor
    Cannabidiol
    Corpus Striatum
    Disease Models, Animal
    Dopamine Agents
    Dose-Response Relationship, Drug
    Drug Administration Schedule
    Hippocampus
    Hyperkinesis
    Male
    Motor Activity
    Oxidative Stress
    Prefrontal Cortex
    Protein Carbonylation
    Rats
    Rats, Wistar

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19939866

    Citation

    Valvassori, Samira S., et al. "Effects of Cannabidiol On Amphetamine-induced Oxidative Stress Generation in an Animal Model of Mania." Journal of Psychopharmacology (Oxford, England), vol. 25, no. 2, 2011, pp. 274-80.
    Valvassori SS, Elias G, de Souza B, et al. Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania. J Psychopharmacol (Oxford). 2011;25(2):274-80.
    Valvassori, S. S., Elias, G., de Souza, B., Petronilho, F., Dal-Pizzol, F., Kapczinski, F., ... Crippa, J. A. (2011). Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania. Journal of Psychopharmacology (Oxford, England), 25(2), pp. 274-80. doi:10.1177/0269881109106925.
    Valvassori SS, et al. Effects of Cannabidiol On Amphetamine-induced Oxidative Stress Generation in an Animal Model of Mania. J Psychopharmacol (Oxford). 2011;25(2):274-80. PubMed PMID: 19939866.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania. AU - Valvassori,Samira S, AU - Elias,Guilherme, AU - de Souza,Bruna, AU - Petronilho,Fabrícia, AU - Dal-Pizzol,Felipe, AU - Kapczinski,Flávio, AU - Trzesniak,Clarissa, AU - Tumas,Vitor, AU - Dursun,Serdar, AU - Chagas,Marcos Hortes Nisihara, AU - Hallak,Jaime E C, AU - Zuardi,Antonio W, AU - Quevedo,João, AU - Crippa,José A S, Y1 - 2009/11/25/ PY - 2009/11/27/entrez PY - 2009/11/27/pubmed PY - 2011/5/12/medline SP - 274 EP - 80 JF - Journal of psychopharmacology (Oxford, England) JO - J. Psychopharmacol. (Oxford) VL - 25 IS - 2 N2 - Cannabidiol (CBD), a Cannabis sativa constituent, may present a pharmacological profile similar to mood stabilizing drugs, in addition to anti-oxidative and neuroprotective properties. The present study aims to directly investigate the effects of CBD in an animal model of mania induced by D-amphetamine (D-AMPH). In the first model (reversal treatment), rats received saline or D-AMPH (2 mg/kg) once daily intraperitoneal (i.p.) for 14 days, and from the 8th to the 14th day, they were treated with saline or CBD (15, 30 or 60 mg/kg) i.p. twice a day. In the second model (prevention treatment), rats were pretreated with saline or CBD (15, 30, or 60 mg/kg) regime i.p. twice a day, and from the 8th to the 14th day, they also received saline or D-AMPH i.p. once daily. In the hippocampus CBD (15 mg/kg) reversed the d-AMPH-induced damage and increased (30 mg/kg) brain-derived neurotrophic factor (BDNF) expression. In the second experiment, CBD (30 or 60 mg/kg) prevented the D-AMPH-induced formation of carbonyl group in the prefrontal cortex. In the hippocampus and striatum the D-AMPH-induced damage was prevented by CBD (15, 30 or 60 mg/kg). At both treatments CBD did not present any effect against d-AMPH-induced hyperactivity. In conclusion, we could not observe effects on locomotion, but CBD protect against d-AMPH-induced oxidative protein damage and increased BDNF levels in the reversal model and these effects vary depending on the brain regions evaluated and doses of CBD administered. SN - 1461-7285 UR - https://www.unboundmedicine.com/medline/citation/19939866/full_citation/Effects_of_cannabidiol_on_amphetamine_induced_oxidative_stress_generation_in_an_animal_model_of_mania_ L2 - http://journals.sagepub.com/doi/full/10.1177/0269881109106925?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -