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Glycated albumin levels are higher relative to glycated haemoglobin levels in gastrectomized subjects.
Ann Clin Biochem. 2010 Jan; 47(Pt 1):39-43.AC

Abstract

BACKGROUND

In gastrectomized subjects, oral glucose tolerance test often shows marked hyperglycaemia (oxyhyperglycaemia) after glucose loading. Because serum glycated albumin (GA) has been shown to better reflect postprandial and maximum plasma glucose levels, we investigated whether or not the clinical significance of serum GA and glycated haemoglobin (HbA(1C)) in non-diabetic gastrectomized subjects differs.

METHODS

During health examinations, 62 non-diabetic subjects with a history of gastrectomy and 87 non-diabetic control subjects were selected in the present study. Body mass index (BMI) in the gastrectomy group was significantly lower than in the control group.

RESULTS

Fasting plasma glucose levels were significantly lower in the gastrectomized subjects than in the control subjects. Although both HbA(1C) and serum GA were significantly higher in the gastrectomized subjects, there was a significant difference in GA/HbA(1C) ratio between the gastrectomized subjects and the control subjects. BMI-adjusted serum GA, based on our previous finding of inverse influence of BMI on serum GA, was also significantly higher in the gastrectomized subjects than in the controls.

CONCLUSIONS

Serum GA is higher relative to HbA(1C) in gastrectomized subjects. This suggests that serum GA may be a better marker than HbA(1C) for glycaemic excursion in these subjects.

Authors+Show Affiliations

Department of Internal Medicine, Kinki Central Hospital, Hyogo, USA. koga_m@kich.itami.hyogo.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19940202

Citation

Koga, Masafumi, et al. "Glycated Albumin Levels Are Higher Relative to Glycated Haemoglobin Levels in Gastrectomized Subjects." Annals of Clinical Biochemistry, vol. 47, no. Pt 1, 2010, pp. 39-43.
Koga M, Murai J, Saito H, et al. Glycated albumin levels are higher relative to glycated haemoglobin levels in gastrectomized subjects. Ann Clin Biochem. 2010;47(Pt 1):39-43.
Koga, M., Murai, J., Saito, H., Mukai, M., Matsumoto, S., & Kasayama, S. (2010). Glycated albumin levels are higher relative to glycated haemoglobin levels in gastrectomized subjects. Annals of Clinical Biochemistry, 47(Pt 1), 39-43. https://doi.org/10.1258/acb.2009.009127
Koga M, et al. Glycated Albumin Levels Are Higher Relative to Glycated Haemoglobin Levels in Gastrectomized Subjects. Ann Clin Biochem. 2010;47(Pt 1):39-43. PubMed PMID: 19940202.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glycated albumin levels are higher relative to glycated haemoglobin levels in gastrectomized subjects. AU - Koga,Masafumi, AU - Murai,Jun, AU - Saito,Hiroshi, AU - Mukai,Mikio, AU - Matsumoto,Soeko, AU - Kasayama,Soji, Y1 - 2009/11/25/ PY - 2009/11/27/entrez PY - 2009/11/27/pubmed PY - 2010/3/6/medline SP - 39 EP - 43 JF - Annals of clinical biochemistry JO - Ann Clin Biochem VL - 47 IS - Pt 1 N2 - BACKGROUND: In gastrectomized subjects, oral glucose tolerance test often shows marked hyperglycaemia (oxyhyperglycaemia) after glucose loading. Because serum glycated albumin (GA) has been shown to better reflect postprandial and maximum plasma glucose levels, we investigated whether or not the clinical significance of serum GA and glycated haemoglobin (HbA(1C)) in non-diabetic gastrectomized subjects differs. METHODS: During health examinations, 62 non-diabetic subjects with a history of gastrectomy and 87 non-diabetic control subjects were selected in the present study. Body mass index (BMI) in the gastrectomy group was significantly lower than in the control group. RESULTS: Fasting plasma glucose levels were significantly lower in the gastrectomized subjects than in the control subjects. Although both HbA(1C) and serum GA were significantly higher in the gastrectomized subjects, there was a significant difference in GA/HbA(1C) ratio between the gastrectomized subjects and the control subjects. BMI-adjusted serum GA, based on our previous finding of inverse influence of BMI on serum GA, was also significantly higher in the gastrectomized subjects than in the controls. CONCLUSIONS: Serum GA is higher relative to HbA(1C) in gastrectomized subjects. This suggests that serum GA may be a better marker than HbA(1C) for glycaemic excursion in these subjects. SN - 1758-1001 UR - https://www.unboundmedicine.com/medline/citation/19940202/Glycated_albumin_levels_are_higher_relative_to_glycated_haemoglobin_levels_in_gastrectomized_subjects_ L2 - https://journals.sagepub.com/doi/10.1258/acb.2009.009127?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -