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[New normal ranges for TSH: when to treat?].
Dtsch Med Wochenschr. 2009 Dec; 134(49):2510-3.DM

Abstract

Subclinical forms of thyroid dysfunction rest purely on a biochemical definition. An increase or decrease of TSH compared to the laboratory norm defines the condition with thyroid hormone concentrations still within the norm. Recent population based large surveys defined a much narrower range of TSH levels between 0.3 and 2.5 mU/l. As TSH determinations are subject to modulations due to endogenous and exogenous factors including substantial variations due to the laboratory methods, therapeutic intervention should not be considered when TSH levels are below the long accepted threshold of 4.5-5 mU/l. This is supported by the lack of current data on an increased morbidity under these conditions. In contrast, subtle alterations of TSH in the context of subclinical hyperthyroidism are associated with a significantly higher risk particularly of atrial fibrillation.

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Authors+Show Affiliations

Brabant G
Department of Endocrinology, Christie's Hospital, Manchester, UK. georg.brabant@manchester.ac.uk

MeSH

Antithyroid AgentsAtrial FibrillationCross-Sectional StudiesHumansHyperthyroidismHypothyroidismPredictive Value of TestsPrognosisReference ValuesRisk FactorsThyroid DiseasesThyroid Function TestsThyrotropinThyroxine

Pub Type(s)

English Abstract
Journal Article
Review

Language

ger

PubMed ID

19941233

Citation

Brabant, G. "[New Normal Ranges for TSH: when to Treat?]." Deutsche Medizinische Wochenschrift (1946), vol. 134, no. 49, 2009, pp. 2510-3.
Brabant G. [New normal ranges for TSH: when to treat?]. Dtsch Med Wochenschr. 2009;134(49):2510-3.
Brabant, G. (2009). [New normal ranges for TSH: when to treat?]. Deutsche Medizinische Wochenschrift (1946), 134(49), 2510-3. https://doi.org/10.1055/s-0029-1243054
Brabant G. [New Normal Ranges for TSH: when to Treat?]. Dtsch Med Wochenschr. 2009;134(49):2510-3. PubMed PMID: 19941233.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [New normal ranges for TSH: when to treat?]. A1 - Brabant,G, Y1 - 2009/11/25/ PY - 2009/11/27/entrez PY - 2009/11/27/pubmed PY - 2009/12/16/medline SP - 2510 EP - 3 JF - Deutsche medizinische Wochenschrift (1946) JO - Dtsch Med Wochenschr VL - 134 IS - 49 N2 - Subclinical forms of thyroid dysfunction rest purely on a biochemical definition. An increase or decrease of TSH compared to the laboratory norm defines the condition with thyroid hormone concentrations still within the norm. Recent population based large surveys defined a much narrower range of TSH levels between 0.3 and 2.5 mU/l. As TSH determinations are subject to modulations due to endogenous and exogenous factors including substantial variations due to the laboratory methods, therapeutic intervention should not be considered when TSH levels are below the long accepted threshold of 4.5-5 mU/l. This is supported by the lack of current data on an increased morbidity under these conditions. In contrast, subtle alterations of TSH in the context of subclinical hyperthyroidism are associated with a significantly higher risk particularly of atrial fibrillation. SN - 1439-4413 UR - https://www.unboundmedicine.com/medline/citation/19941233/[New_normal_ranges_for_TSH:_when_to_treat]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0029-1243054 DB - PRIME DP - Unbound Medicine ER -