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Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure-activity relationships.
Planta Med 2010; 76(6):644-7PM

Abstract

The gram-scale isolation of the major flavonolignan diastereoisomers from milk thistle (Silybum marianum) extract provided an entree into the isolation of two related analogues that are present in extremely minute quantities. The isolation and structure elucidation of these two new compounds, which we have termed isosilybin C and isosilybin D due to their structural similarities to isosilybin A and isosilybin B, respectively, afforded a preliminary analysis of structure-activity relationships toward prostate cancer growth, survival, and apoptotic endpoints.

Authors+Show Affiliations

Natural Products Laboratory, Research Triangle Institute, Research Triangle Park, North Carolina, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19941262

Citation

Sy-Cordero, Arlene, et al. "Large-scale Isolation of Flavonolignans From Silybum Marianum Extract Affords New Minor Constituents and Preliminary Structure-activity Relationships." Planta Medica, vol. 76, no. 6, 2010, pp. 644-7.
Sy-Cordero A, Graf TN, Nakanishi Y, et al. Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure-activity relationships. Planta Med. 2010;76(6):644-7.
Sy-Cordero, A., Graf, T. N., Nakanishi, Y., Wani, M. C., Agarwal, R., Kroll, D. J., & Oberlies, N. H. (2010). Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure-activity relationships. Planta Medica, 76(6), pp. 644-7. doi:10.1055/s-0029-1240624.
Sy-Cordero A, et al. Large-scale Isolation of Flavonolignans From Silybum Marianum Extract Affords New Minor Constituents and Preliminary Structure-activity Relationships. Planta Med. 2010;76(6):644-7. PubMed PMID: 19941262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure-activity relationships. AU - Sy-Cordero,Arlene, AU - Graf,Tyler N, AU - Nakanishi,Yuka, AU - Wani,Mansukh C, AU - Agarwal,Rajesh, AU - Kroll,David J, AU - Oberlies,Nicholas H, Y1 - 2009/11/25/ PY - 2009/11/27/entrez PY - 2009/11/27/pubmed PY - 2010/7/24/medline SP - 644 EP - 7 JF - Planta medica JO - Planta Med. VL - 76 IS - 6 N2 - The gram-scale isolation of the major flavonolignan diastereoisomers from milk thistle (Silybum marianum) extract provided an entree into the isolation of two related analogues that are present in extremely minute quantities. The isolation and structure elucidation of these two new compounds, which we have termed isosilybin C and isosilybin D due to their structural similarities to isosilybin A and isosilybin B, respectively, afforded a preliminary analysis of structure-activity relationships toward prostate cancer growth, survival, and apoptotic endpoints. SN - 1439-0221 UR - https://www.unboundmedicine.com/medline/citation/19941262/Large_scale_isolation_of_flavonolignans_from_Silybum_marianum_extract_affords_new_minor_constituents_and_preliminary_structure_activity_relationships_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0029-1240624 DB - PRIME DP - Unbound Medicine ER -