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Central beta-adrenergic receptors play an important role in the enhancing effect of voluntary exercise on learning and memory in rat.
Behav Brain Res. 2010 Mar 17; 208(1):189-93.BB

Abstract

The beneficial effects of physical activity and exercise on brain functions such as improvement in learning and memory are well documented. The aim of this study was to examine the role of the beta-adrenergic system in voluntary exercise-induced enhancement of learning and memory in rat. In order to block the beta-adrenergic receptors, the animals were received propranolol (a beta-blocker), or nadolol (a peripherally acting beta-blocker) before each night of five consecutive nights of exercise. Then their learning and memory were tested on the water maze task using a two-trials-per-day for 5 consecutive days. A probe trial was performed 2 days after the last training day. Our results showed that propranolol, but not nadolol reversed the exercise-induced improvement in learning and memory in rat. Our findings indicate that central beta-adrenergic receptors play an important role in mediating the beneficial effects of voluntary exercise on learning and memory.

Authors+Show Affiliations

Laboratory of Learning and Memory, Department and Research Center of Physiology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19941907

Citation

Ebrahimi, Shima, et al. "Central Beta-adrenergic Receptors Play an Important Role in the Enhancing Effect of Voluntary Exercise On Learning and Memory in Rat." Behavioural Brain Research, vol. 208, no. 1, 2010, pp. 189-93.
Ebrahimi S, Rashidy-Pour A, Vafaei AA, et al. Central beta-adrenergic receptors play an important role in the enhancing effect of voluntary exercise on learning and memory in rat. Behav Brain Res. 2010;208(1):189-93.
Ebrahimi, S., Rashidy-Pour, A., Vafaei, A. A., & Akhavan, M. M. (2010). Central beta-adrenergic receptors play an important role in the enhancing effect of voluntary exercise on learning and memory in rat. Behavioural Brain Research, 208(1), 189-93. https://doi.org/10.1016/j.bbr.2009.11.032
Ebrahimi S, et al. Central Beta-adrenergic Receptors Play an Important Role in the Enhancing Effect of Voluntary Exercise On Learning and Memory in Rat. Behav Brain Res. 2010 Mar 17;208(1):189-93. PubMed PMID: 19941907.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Central beta-adrenergic receptors play an important role in the enhancing effect of voluntary exercise on learning and memory in rat. AU - Ebrahimi,Shima, AU - Rashidy-Pour,Ali, AU - Vafaei,Abbas A, AU - Akhavan,Maziar M, Y1 - 2009/11/24/ PY - 2009/10/06/received PY - 2009/11/15/revised PY - 2009/11/18/accepted PY - 2009/11/28/entrez PY - 2009/11/28/pubmed PY - 2010/5/4/medline SP - 189 EP - 93 JF - Behavioural brain research JO - Behav Brain Res VL - 208 IS - 1 N2 - The beneficial effects of physical activity and exercise on brain functions such as improvement in learning and memory are well documented. The aim of this study was to examine the role of the beta-adrenergic system in voluntary exercise-induced enhancement of learning and memory in rat. In order to block the beta-adrenergic receptors, the animals were received propranolol (a beta-blocker), or nadolol (a peripherally acting beta-blocker) before each night of five consecutive nights of exercise. Then their learning and memory were tested on the water maze task using a two-trials-per-day for 5 consecutive days. A probe trial was performed 2 days after the last training day. Our results showed that propranolol, but not nadolol reversed the exercise-induced improvement in learning and memory in rat. Our findings indicate that central beta-adrenergic receptors play an important role in mediating the beneficial effects of voluntary exercise on learning and memory. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/19941907/Central_beta_adrenergic_receptors_play_an_important_role_in_the_enhancing_effect_of_voluntary_exercise_on_learning_and_memory_in_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(09)00709-8 DB - PRIME DP - Unbound Medicine ER -