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Role of ethanol in kava hepatotoxicity.
Phytother Res. 2010 Apr; 24(4):475-80.PR

Abstract

Kava is known for its recreational, ceremonial and medicinal use in the Pacific. The aqueous non-alcoholic drink of kava rhizome produces intoxicating, relaxing and soothing effects. While kava's medicinal effects receive worldwide recognition, kava-containing products came under scrutiny after over 100 reports of spontaneous adverse hepatic effects. Many mechanisms have been postulated to explain the unexpected toxicity, one being pharmacokinetic interactions between kavalactones and co-administered drugs involving cytochrome P450 enzyme system. Alcohol is often co-injested in kava hepatotoxicity cases. This review evaluates the possible hepatotoxicity mechanisms involving alcohol and kava.

Authors+Show Affiliations

Faculty of Pharmacy, University of Sydney, NSW, Australia. dean@pharm.usyd.edu.auNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19943335

Citation

Li, X Z., and I Ramzan. "Role of Ethanol in Kava Hepatotoxicity." Phytotherapy Research : PTR, vol. 24, no. 4, 2010, pp. 475-80.
Li XZ, Ramzan I. Role of ethanol in kava hepatotoxicity. Phytother Res. 2010;24(4):475-80.
Li, X. Z., & Ramzan, I. (2010). Role of ethanol in kava hepatotoxicity. Phytotherapy Research : PTR, 24(4), 475-80. https://doi.org/10.1002/ptr.3046
Li XZ, Ramzan I. Role of Ethanol in Kava Hepatotoxicity. Phytother Res. 2010;24(4):475-80. PubMed PMID: 19943335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of ethanol in kava hepatotoxicity. AU - Li,X Z, AU - Ramzan,I, PY - 2009/11/28/entrez PY - 2009/11/28/pubmed PY - 2010/6/29/medline SP - 475 EP - 80 JF - Phytotherapy research : PTR JO - Phytother Res VL - 24 IS - 4 N2 - Kava is known for its recreational, ceremonial and medicinal use in the Pacific. The aqueous non-alcoholic drink of kava rhizome produces intoxicating, relaxing and soothing effects. While kava's medicinal effects receive worldwide recognition, kava-containing products came under scrutiny after over 100 reports of spontaneous adverse hepatic effects. Many mechanisms have been postulated to explain the unexpected toxicity, one being pharmacokinetic interactions between kavalactones and co-administered drugs involving cytochrome P450 enzyme system. Alcohol is often co-injested in kava hepatotoxicity cases. This review evaluates the possible hepatotoxicity mechanisms involving alcohol and kava. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/19943335/Role_of_ethanol_in_kava_hepatotoxicity_ L2 - https://doi.org/10.1002/ptr.3046 DB - PRIME DP - Unbound Medicine ER -