Tags

Type your tag names separated by a space and hit enter

From genes to proteins in mendelian Parkinson's disease: an overview.
Anat Rec (Hoboken). 2009 Dec; 292(12):1893-901.AR

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. A progressive movement disorder typified by the production of bradykinesia, tremor, rigidity, and impairment of postural reflexes, PD is characterized by a depletion of dopamine in the striatum. For the last decade, several Mendelian forms of PD have been identified. Mutations in these genes potentially lead to autosomal dominant (alpha-synuclein and LRRK2), or autosomal recessive PD (Parkin, PINK1, DJ1, and ATP13A2). This article will spotlight these six distinct genes unambiguously associated with Mendelian PD and the function of their encoded proteins.

Authors+Show Affiliations

Boğaziçi University, Molecular Biology and Genetics Department, Neurodegeneration Research Laboratory, Istanbul, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19943343

Citation

Pirkevi, Caroline, et al. "From Genes to Proteins in Mendelian Parkinson's Disease: an Overview." Anatomical Record (Hoboken, N.J. : 2007), vol. 292, no. 12, 2009, pp. 1893-901.
Pirkevi C, Lesage S, Brice A, et al. From genes to proteins in mendelian Parkinson's disease: an overview. Anat Rec (Hoboken). 2009;292(12):1893-901.
Pirkevi, C., Lesage, S., Brice, A., & Başak, A. N. (2009). From genes to proteins in mendelian Parkinson's disease: an overview. Anatomical Record (Hoboken, N.J. : 2007), 292(12), 1893-901. https://doi.org/10.1002/ar.20968
Pirkevi C, et al. From Genes to Proteins in Mendelian Parkinson's Disease: an Overview. Anat Rec (Hoboken). 2009;292(12):1893-901. PubMed PMID: 19943343.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - From genes to proteins in mendelian Parkinson's disease: an overview. AU - Pirkevi,Caroline, AU - Lesage,Suzanne, AU - Brice,Alexis, AU - Başak,A Nazli, PY - 2009/11/28/entrez PY - 2009/11/28/pubmed PY - 2010/2/27/medline SP - 1893 EP - 901 JF - Anatomical record (Hoboken, N.J. : 2007) JO - Anat Rec (Hoboken) VL - 292 IS - 12 N2 - Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. A progressive movement disorder typified by the production of bradykinesia, tremor, rigidity, and impairment of postural reflexes, PD is characterized by a depletion of dopamine in the striatum. For the last decade, several Mendelian forms of PD have been identified. Mutations in these genes potentially lead to autosomal dominant (alpha-synuclein and LRRK2), or autosomal recessive PD (Parkin, PINK1, DJ1, and ATP13A2). This article will spotlight these six distinct genes unambiguously associated with Mendelian PD and the function of their encoded proteins. SN - 1932-8494 UR - https://www.unboundmedicine.com/medline/citation/19943343/From_genes_to_proteins_in_mendelian_Parkinson's_disease:_an_overview_ L2 - https://doi.org/10.1002/ar.20968 DB - PRIME DP - Unbound Medicine ER -