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Diterpenes, sesquiterpenes, and a sesquiterpene-coumarin conjugate from Jatropha integerrima.
J Nat Prod. 2009 Nov; 72(11):2024-7.JN

Abstract

Five new compounds, 2alpha-hydroxyjatropholone (1), 2beta-hydroxyjatropholone (2), 1,5-dioxo-2,3-dihydroxyrhamnofola-4(10),6,11(18),15-tetraene (3), 2-keto-5-hydroxyguai-3,11-diene (4), and a sesquiterpene-coumarin conjugate, jatrophadioxan (5), and nine known compounds have been isolated from the roots of Jatropha integerrima. The structures were established from spectroscopic data, and the relative configuration of 1 was confirmed by X-ray crystallography. Six diterpenes were evaluated for their antiplasmodial, antituberculosis, and cytotoxic activities.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Sutthivaiyakit S
Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand. s_somyote@ru.ac.th
Mongkolvisut W
No affiliation info available
Prabpai S
No affiliation info available
Kongsaeree P
No affiliation info available

MeSH

AnimalsAntimalarialsAntineoplastic Agents, PhytogenicAntitubercular AgentsChlorocebus aethiopsCoumarinsCrystallography, X-RayDiterpenesDrug Resistance, MicrobialDrug Screening Assays, AntitumorJatrophaMicrobial Sensitivity TestsMolecular ConformationMolecular StructureMycobacterium tuberculosisPlant RootsPlants, MedicinalPlasmodium falciparumSesquiterpenesThailand

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19943622

Citation

Sutthivaiyakit, Somyote, et al. "Diterpenes, Sesquiterpenes, and a Sesquiterpene-coumarin Conjugate From Jatropha Integerrima." Journal of Natural Products, vol. 72, no. 11, 2009, pp. 2024-7.
Sutthivaiyakit S, Mongkolvisut W, Prabpai S, et al. Diterpenes, sesquiterpenes, and a sesquiterpene-coumarin conjugate from Jatropha integerrima. J Nat Prod. 2009;72(11):2024-7.
Sutthivaiyakit, S., Mongkolvisut, W., Prabpai, S., & Kongsaeree, P. (2009). Diterpenes, sesquiterpenes, and a sesquiterpene-coumarin conjugate from Jatropha integerrima. Journal of Natural Products, 72(11), 2024-7. https://doi.org/10.1021/np900342b
Sutthivaiyakit S, et al. Diterpenes, Sesquiterpenes, and a Sesquiterpene-coumarin Conjugate From Jatropha Integerrima. J Nat Prod. 2009;72(11):2024-7. PubMed PMID: 19943622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diterpenes, sesquiterpenes, and a sesquiterpene-coumarin conjugate from Jatropha integerrima. AU - Sutthivaiyakit,Somyote, AU - Mongkolvisut,Wantana, AU - Prabpai,Samran, AU - Kongsaeree,Palangpon, PY - 2009/12/1/entrez PY - 2009/12/1/pubmed PY - 2009/12/17/medline SP - 2024 EP - 7 JF - Journal of natural products JO - J Nat Prod VL - 72 IS - 11 N2 - Five new compounds, 2alpha-hydroxyjatropholone (1), 2beta-hydroxyjatropholone (2), 1,5-dioxo-2,3-dihydroxyrhamnofola-4(10),6,11(18),15-tetraene (3), 2-keto-5-hydroxyguai-3,11-diene (4), and a sesquiterpene-coumarin conjugate, jatrophadioxan (5), and nine known compounds have been isolated from the roots of Jatropha integerrima. The structures were established from spectroscopic data, and the relative configuration of 1 was confirmed by X-ray crystallography. Six diterpenes were evaluated for their antiplasmodial, antituberculosis, and cytotoxic activities. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/19943622/Diterpenes_sesquiterpenes_and_a_sesquiterpene_coumarin_conjugate_from_Jatropha_integerrima_ L2 - https://doi.org/10.1021/np900342b DB - PRIME DP - Unbound Medicine ER -