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Topical diclofenac solution.
Drugs. 2009; 69(18):2621-32.D

Abstract

Topical diclofenac solution (Pennsaid) is a liquid formulation containing the NSAID diclofenac sodium (1.5% w/w). The solution base contains 45% w/w dimethyl sulfoxide (DMSO) to enhance the absorption of diclofenac through the skin. Topical diclofenac solution is applied directly to the knee for treatment of symptoms associated with osteoarthritis of the knee. In well designed 4- to 12-week trials in patients with primary osteoarthritis of the knee, topical diclofenac solution (40 drops four times daily) was significantly more effective than placebo or vehicle control (carrier solution without diclofenac) for improving Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index pain and physical function, and improving patient global assessment (PGA) and/or patient overall health assessment scores from baseline to the final assessments. Topical diclofenac solution (50 drops three times daily) was as effective as oral diclofenac 150 mg/day for improving WOMAC pain and physical function and PGA scores in a 12-week double-blind study in patients with osteoarthritis of the knee. Topical diclofenac solution was generally well tolerated. The most common treatment-emergent adverse event experienced by topical diclofenac solution recipients was dry skin at the application site. Gastrointestinal adverse events and abnormal laboratory parameters were less common with topical diclofenac solution than with oral diclofenac.

Authors+Show Affiliations

Adis, a Wolters Kluwer Business, Auckland, New Zealand. demail@adis.co.nz

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19943711

Citation

Moen, Marit D.. "Topical Diclofenac Solution." Drugs, vol. 69, no. 18, 2009, pp. 2621-32.
Moen MD. Topical diclofenac solution. Drugs. 2009;69(18):2621-32.
Moen, M. D. (2009). Topical diclofenac solution. Drugs, 69(18), 2621-32. https://doi.org/10.2165/11202850-000000000-00000
Moen MD. Topical Diclofenac Solution. Drugs. 2009;69(18):2621-32. PubMed PMID: 19943711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Topical diclofenac solution. A1 - Moen,Marit D, PY - 2009/12/1/entrez PY - 2009/12/1/pubmed PY - 2010/4/28/medline SP - 2621 EP - 32 JF - Drugs JO - Drugs VL - 69 IS - 18 N2 - Topical diclofenac solution (Pennsaid) is a liquid formulation containing the NSAID diclofenac sodium (1.5% w/w). The solution base contains 45% w/w dimethyl sulfoxide (DMSO) to enhance the absorption of diclofenac through the skin. Topical diclofenac solution is applied directly to the knee for treatment of symptoms associated with osteoarthritis of the knee. In well designed 4- to 12-week trials in patients with primary osteoarthritis of the knee, topical diclofenac solution (40 drops four times daily) was significantly more effective than placebo or vehicle control (carrier solution without diclofenac) for improving Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index pain and physical function, and improving patient global assessment (PGA) and/or patient overall health assessment scores from baseline to the final assessments. Topical diclofenac solution (50 drops three times daily) was as effective as oral diclofenac 150 mg/day for improving WOMAC pain and physical function and PGA scores in a 12-week double-blind study in patients with osteoarthritis of the knee. Topical diclofenac solution was generally well tolerated. The most common treatment-emergent adverse event experienced by topical diclofenac solution recipients was dry skin at the application site. Gastrointestinal adverse events and abnormal laboratory parameters were less common with topical diclofenac solution than with oral diclofenac. SN - 1179-1950 UR - https://www.unboundmedicine.com/medline/citation/19943711/Topical_diclofenac_solution_ L2 - https://dx.doi.org/10.2165/11202850-000000000-00000 DB - PRIME DP - Unbound Medicine ER -