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An economic evaluation of alternative test-intervention strategies to prevent spontaneous pre-term birth in singleton pregnancies.

Abstract

OBJECTIVE

To investigate the potential cost-effectiveness of alternative 'test-and-treat' strategies in the prevention of spontaneous pre-term birth before 34 and 37 weeks' gestation.

DESIGN

Model-based economic evaluation. Setting. Clinics, general practices, health centers or any setting delivering antenatal care.

POPULATION

Asymptomatic women in early pregnancy and symptomatic women with threatened pre-term labor in later pregnancy.

METHODS

Data from systematic reviews of effectiveness and accuracy were combined into strategies and analyzed using a decision-tree model. Full deterministic and probabilistic sensitivity analyses were carried out.

MAIN OUTCOME MEASURES

Spontaneous pre-term labor avoided for asymptomatic women and spontaneous pre-term birth avoided for symptomatic women.

RESULTS

The systematic reviews identified evidence on the accuracy of 22 types of tests and on the effectiveness of 40 possible interventions. Cost data were based on secondary evidence, supplemented with primary data from local sources. Testing prior to intervention was not shown to be the most cost-effective strategy in the main analyses for 34 and 37 weeks. Prophylactic fish oil in asymptomatic women, without prior testing, was highlighted as potentially cost-effective in preventing threatened pre-term labor before 34 weeks. In symptomatic women with a viable pregnancy, indomethacin without prior testing was a potentially cost-effective strategy to prevent pre-term birth occurring before 37 weeks.

CONCLUSION

An effective, affordable and safe intervention applied to all mothers without prior testing is likely to be the most cost-effective strategy in the prevention of spontaneous pre-term labor and birth. The results reported in this paper are important for prioritizing future research, world-wide.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Health Economics Unit, School of Population and Health Sciences, University of Birmingham, Birmingham, UK.

    , , , , ,

    Source

    MeSH

    Cervical Length Measurement
    Cost-Benefit Analysis
    Decision Support Techniques
    Female
    Humans
    Models, Statistical
    Pregnancy
    Premature Birth

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    19943821

    Citation

    Tsourapas, Angelos, et al. "An Economic Evaluation of Alternative Test-intervention Strategies to Prevent Spontaneous Pre-term Birth in Singleton Pregnancies." Acta Obstetricia Et Gynecologica Scandinavica, vol. 88, no. 12, 2009, pp. 1319-30.
    Tsourapas A, Roberts TE, Barton PM, et al. An economic evaluation of alternative test-intervention strategies to prevent spontaneous pre-term birth in singleton pregnancies. Acta Obstet Gynecol Scand. 2009;88(12):1319-30.
    Tsourapas, A., Roberts, T. E., Barton, P. M., Honest, H., Forbes, C., Hyde, C. J., & Khan, K. S. (2009). An economic evaluation of alternative test-intervention strategies to prevent spontaneous pre-term birth in singleton pregnancies. Acta Obstetricia Et Gynecologica Scandinavica, 88(12), pp. 1319-30. doi:10.3109/00016340903410873.
    Tsourapas A, et al. An Economic Evaluation of Alternative Test-intervention Strategies to Prevent Spontaneous Pre-term Birth in Singleton Pregnancies. Acta Obstet Gynecol Scand. 2009;88(12):1319-30. PubMed PMID: 19943821.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - An economic evaluation of alternative test-intervention strategies to prevent spontaneous pre-term birth in singleton pregnancies. AU - Tsourapas,Angelos, AU - Roberts,Tracy E, AU - Barton,Pelham M, AU - Honest,Honest, AU - Forbes,Carol, AU - Hyde,Chris J, AU - Khan,Khalid S, PY - 2009/12/1/entrez PY - 2009/12/1/pubmed PY - 2010/1/26/medline SP - 1319 EP - 30 JF - Acta obstetricia et gynecologica Scandinavica JO - Acta Obstet Gynecol Scand VL - 88 IS - 12 N2 - OBJECTIVE: To investigate the potential cost-effectiveness of alternative 'test-and-treat' strategies in the prevention of spontaneous pre-term birth before 34 and 37 weeks' gestation. DESIGN: Model-based economic evaluation. Setting. Clinics, general practices, health centers or any setting delivering antenatal care. POPULATION: Asymptomatic women in early pregnancy and symptomatic women with threatened pre-term labor in later pregnancy. METHODS: Data from systematic reviews of effectiveness and accuracy were combined into strategies and analyzed using a decision-tree model. Full deterministic and probabilistic sensitivity analyses were carried out. MAIN OUTCOME MEASURES: Spontaneous pre-term labor avoided for asymptomatic women and spontaneous pre-term birth avoided for symptomatic women. RESULTS: The systematic reviews identified evidence on the accuracy of 22 types of tests and on the effectiveness of 40 possible interventions. Cost data were based on secondary evidence, supplemented with primary data from local sources. Testing prior to intervention was not shown to be the most cost-effective strategy in the main analyses for 34 and 37 weeks. Prophylactic fish oil in asymptomatic women, without prior testing, was highlighted as potentially cost-effective in preventing threatened pre-term labor before 34 weeks. In symptomatic women with a viable pregnancy, indomethacin without prior testing was a potentially cost-effective strategy to prevent pre-term birth occurring before 37 weeks. CONCLUSION: An effective, affordable and safe intervention applied to all mothers without prior testing is likely to be the most cost-effective strategy in the prevention of spontaneous pre-term labor and birth. The results reported in this paper are important for prioritizing future research, world-wide. SN - 1600-0412 UR - https://www.unboundmedicine.com/medline/citation/19943821/abstract/An_economic_evaluation_of_alternative_test_intervention_strategies_to_prevent_spontaneous_pre_term_birth_in_singleton_pregnancies L2 - https://doi.org/10.3109/00016340903410873 DB - PRIME DP - Unbound Medicine ER -