Tags

Type your tag names separated by a space and hit enter

Zollinger-Ellison syndrome: prospective assessment of abdominal US in the localization of gastrinomas.
Radiology. 1991 Mar; 178(3):763-7.R

Abstract

The ability of abdominal ultrasound (US) to help localize gastrinomas was prospectively studied in 79 patients with Zollinger-Ellison syndrome. The results were assessed by means of laparotomy, autopsy, or percutaneous liver biopsy. For hepatic gastrinoma, US had a sensitivity of 63% and a specificity of 100%, with a positive predictive value of 100% and a negative predictive value of 89%. US was slightly less sensitive for detecting gastrinoma in the liver than were computed tomography (CT) (66%) and selective angiography (78%). For detection of extrahepatic gastrinoma, US had a sensitivity of 30%, a specificity of 94%, a positive predictive value of 100%, and a negative predictive value of 25%. US enabled detection of tumor in eight cases not detected with CT and in four not detected with angiography. Specificity for extrahepatic gastrinoma was similar for all three modalities (89%-95%). CT and US were equally effective for the detection of extrahepatic gastrinoma, and angiography was significantly more effective than both US and CT (P less than .01). The authors conclude that US, although of low sensitivity, remains useful as the initial imaging modality in patients with Zollinger-Ellison syndrome.

Authors+Show Affiliations

Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

1994415

Citation

London, J F., et al. "Zollinger-Ellison Syndrome: Prospective Assessment of Abdominal US in the Localization of Gastrinomas." Radiology, vol. 178, no. 3, 1991, pp. 763-7.
London JF, Shawker TH, Doppman JL, et al. Zollinger-Ellison syndrome: prospective assessment of abdominal US in the localization of gastrinomas. Radiology. 1991;178(3):763-7.
London, J. F., Shawker, T. H., Doppman, J. L., Frucht, H. H., Vinayek, R., Stark, H. A., Miller, L. S., Miller, D. L., Norton, J. A., & Jensen, R. T. (1991). Zollinger-Ellison syndrome: prospective assessment of abdominal US in the localization of gastrinomas. Radiology, 178(3), 763-7.
London JF, et al. Zollinger-Ellison Syndrome: Prospective Assessment of Abdominal US in the Localization of Gastrinomas. Radiology. 1991;178(3):763-7. PubMed PMID: 1994415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zollinger-Ellison syndrome: prospective assessment of abdominal US in the localization of gastrinomas. A1 - London,J F, AU - Shawker,T H, AU - Doppman,J L, AU - Frucht,H H, AU - Vinayek,R, AU - Stark,H A, AU - Miller,L S, AU - Miller,D L, AU - Norton,J A, AU - Jensen,R T, PY - 1991/3/1/pubmed PY - 1991/3/1/medline PY - 1991/3/1/entrez SP - 763 EP - 7 JF - Radiology JO - Radiology VL - 178 IS - 3 N2 - The ability of abdominal ultrasound (US) to help localize gastrinomas was prospectively studied in 79 patients with Zollinger-Ellison syndrome. The results were assessed by means of laparotomy, autopsy, or percutaneous liver biopsy. For hepatic gastrinoma, US had a sensitivity of 63% and a specificity of 100%, with a positive predictive value of 100% and a negative predictive value of 89%. US was slightly less sensitive for detecting gastrinoma in the liver than were computed tomography (CT) (66%) and selective angiography (78%). For detection of extrahepatic gastrinoma, US had a sensitivity of 30%, a specificity of 94%, a positive predictive value of 100%, and a negative predictive value of 25%. US enabled detection of tumor in eight cases not detected with CT and in four not detected with angiography. Specificity for extrahepatic gastrinoma was similar for all three modalities (89%-95%). CT and US were equally effective for the detection of extrahepatic gastrinoma, and angiography was significantly more effective than both US and CT (P less than .01). The authors conclude that US, although of low sensitivity, remains useful as the initial imaging modality in patients with Zollinger-Ellison syndrome. SN - 0033-8419 UR - https://www.unboundmedicine.com/medline/citation/1994415/Zollinger_Ellison_syndrome:_prospective_assessment_of_abdominal_US_in_the_localization_of_gastrinomas_ DB - PRIME DP - Unbound Medicine ER -