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Atrial fibrillation and obesity among older Chinese: the Guangzhou Biobank Cohort Study.
Int J Cardiol. 2011 Apr 01; 148(1):48-52.IJ

Abstract

BACKGROUND

Atrial fibrillation (AF) is the most common form of arrhythmia, and its prevalence is increasing. Few studies have examined its association with obesity as defined by different criteria, particularly in developing countries. We investigated the association between atrial fibrillation (AF) and obesity indices among older Chinese.

METHODS

We conducted a community-based nested case control study using cross-sectional data of 5882 men and 14,548 women aged 50 or above from Phases I and II (September 2003 to May 2006) of the Guangzhou Biobank Cohort Study (GBCS). AF cases were identified by the 12-lead body surface electrocardiogram.

RESULTS

159 AF cases (65 men and 94 women) were identified from 19,964 participants with ECG records. 9249 participants with other abnormal ECG findings were excluded, resulting in a case control comparison on 159 AF cases and 10,369 controls. After multivariate adjustment, BMI (adjusted odds ratio (OR) 1.06 per kg/m(2), 95% confidence interval (CI)=1.01-1.11) and waist circumference (adjusted OR 1.02 per cm (1.00-1.04)) were significant risk factors. The adjusted OR per Z-score [(individual value-mean)/standard deviation] for BMI and waist circumference was 1.21 (1.03-1.41) and 1.18 (1.01-1.38) respectively.

CONCLUSIONS

This is the first report showing that both general and central obesity are associated with increased risk of AF in an Eastern population with much lower level of obesity than in the West. As both AF and obesity are increasing in developing countries, the results should have important public health implications.

Authors+Show Affiliations

Department of Community Medicine, School of Public Health, University of Hong Kong, Hong Kong.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19944468

Citation

Long, Mei Jing, et al. "Atrial Fibrillation and Obesity Among Older Chinese: the Guangzhou Biobank Cohort Study." International Journal of Cardiology, vol. 148, no. 1, 2011, pp. 48-52.
Long MJ, Jiang CQ, Lam TH, et al. Atrial fibrillation and obesity among older Chinese: the Guangzhou Biobank Cohort Study. Int J Cardiol. 2011;148(1):48-52.
Long, M. J., Jiang, C. Q., Lam, T. H., Xu, L., Zhang, W. S., Lin, J. M., Ou, J. P., & Cheng, K. K. (2011). Atrial fibrillation and obesity among older Chinese: the Guangzhou Biobank Cohort Study. International Journal of Cardiology, 148(1), 48-52. https://doi.org/10.1016/j.ijcard.2009.10.022
Long MJ, et al. Atrial Fibrillation and Obesity Among Older Chinese: the Guangzhou Biobank Cohort Study. Int J Cardiol. 2011 Apr 1;148(1):48-52. PubMed PMID: 19944468.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atrial fibrillation and obesity among older Chinese: the Guangzhou Biobank Cohort Study. AU - Long,Mei Jing, AU - Jiang,Chao Qiang, AU - Lam,Tai Hing, AU - Xu,Lin, AU - Zhang,Wei Sen, AU - Lin,Jie Ming, AU - Ou,Jian Ping, AU - Cheng,Kar Keung, Y1 - 2009/11/26/ PY - 2009/08/10/received PY - 2009/10/18/accepted PY - 2009/12/1/entrez PY - 2009/12/1/pubmed PY - 2012/2/15/medline SP - 48 EP - 52 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 148 IS - 1 N2 - BACKGROUND: Atrial fibrillation (AF) is the most common form of arrhythmia, and its prevalence is increasing. Few studies have examined its association with obesity as defined by different criteria, particularly in developing countries. We investigated the association between atrial fibrillation (AF) and obesity indices among older Chinese. METHODS: We conducted a community-based nested case control study using cross-sectional data of 5882 men and 14,548 women aged 50 or above from Phases I and II (September 2003 to May 2006) of the Guangzhou Biobank Cohort Study (GBCS). AF cases were identified by the 12-lead body surface electrocardiogram. RESULTS: 159 AF cases (65 men and 94 women) were identified from 19,964 participants with ECG records. 9249 participants with other abnormal ECG findings were excluded, resulting in a case control comparison on 159 AF cases and 10,369 controls. After multivariate adjustment, BMI (adjusted odds ratio (OR) 1.06 per kg/m(2), 95% confidence interval (CI)=1.01-1.11) and waist circumference (adjusted OR 1.02 per cm (1.00-1.04)) were significant risk factors. The adjusted OR per Z-score [(individual value-mean)/standard deviation] for BMI and waist circumference was 1.21 (1.03-1.41) and 1.18 (1.01-1.38) respectively. CONCLUSIONS: This is the first report showing that both general and central obesity are associated with increased risk of AF in an Eastern population with much lower level of obesity than in the West. As both AF and obesity are increasing in developing countries, the results should have important public health implications. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/19944468/Atrial_fibrillation_and_obesity_among_older_Chinese:_the_Guangzhou_Biobank_Cohort_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(09)01521-6 DB - PRIME DP - Unbound Medicine ER -