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Adolescent cannabis use increases risk for cocaine-induced paranoia.

Abstract

Cannabis can produce and/or exacerbate psychotic symptoms in vulnerable individuals. Early exposure to cannabis, particularly in combination with genetic factors, increases the risk of a subsequent, primary, psychotic disorder. Because paranoia is a common feature of stimulant abuse and cocaine-dependent individuals frequently endorse a history of cannabis abuse, we examined whether early cannabis exposure, in conjunction with polymorphic variation in the catechol-O-methyl transferase gene (COMT Val158Met), influences the risk for cocaine-induced paranoia (CIP).

METHODS

Cannabis-use history was obtained in 1140 cocaine-dependent individuals from a family-based (affected sibling pair) study using the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA). Logistic regression and generalized estimating equations' analyses were used to examine the role of adolescent-onset cannabis use (< or =15 years of age) on CIP risk, both controlling for previously implicated CIP risk factors and familial relationships, and considering potential interactions with COMT Val158Met genotype.

RESULTS

Cocaine-dependent individuals who endorsed CIP had significantly higher rates of adolescent-onset cannabis use than those without CIP (62.2% vs. 50.2%; chi(2)=15.2, df=1, p<0.0001), a finding that remained after controlling for sibling correlations and other risk factors. There were no effects of COMT genotype or genotype by early cannabis onset interactions. A modest (OR=1.4) and nearly significant (p=0.053) effect of CIP status in probands on CIP status in siblings was also noted.

CONCLUSIONS

Adolescent-onset cannabis use increases the risk of CIP in cocaine-dependent individuals. COMT genotype and its interaction with early cannabis exposure did not emerge as significant predictors of CIP. In addition, trait vulnerability to CIP may also be familial in nature.

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  • Authors+Show Affiliations

    ,

    Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.

    , , , , , ,

    Source

    Drug and alcohol dependence 107:2-3 2010 Mar 01 pg 196-201

    MeSH

    Adolescent
    Adolescent Behavior
    Age Factors
    Age of Onset
    Cannabis
    Catechol O-Methyltransferase
    Cocaine-Related Disorders
    Female
    Gene Frequency
    Genetic Predisposition to Disease
    Humans
    Logistic Models
    Male
    Paranoid Disorders
    Polymerase Chain Reaction
    Prevalence
    Psychiatric Status Rating Scales
    Risk Factors
    Severity of Illness Index
    Siblings
    United States

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19944543

    Citation

    TY - JOUR T1 - Adolescent cannabis use increases risk for cocaine-induced paranoia. AU - Kalayasiri,Rasmon, AU - Gelernter,Joel, AU - Farrer,Lindsay, AU - Weiss,Roger, AU - Brady,Kathleen, AU - Gueorguieva,Ralitza, AU - Kranzler,Henry R, AU - Malison,Robert T, Y1 - 2009/11/26/ PY - 2009/06/03/received PY - 2009/10/13/revised PY - 2009/10/21/accepted PY - 2009/12/1/entrez PY - 2009/12/1/pubmed PY - 2010/5/15/medline SP - 196 EP - 201 JF - Drug and alcohol dependence JO - Drug Alcohol Depend VL - 107 IS - 2-3 N2 - UNLABELLED: Cannabis can produce and/or exacerbate psychotic symptoms in vulnerable individuals. Early exposure to cannabis, particularly in combination with genetic factors, increases the risk of a subsequent, primary, psychotic disorder. Because paranoia is a common feature of stimulant abuse and cocaine-dependent individuals frequently endorse a history of cannabis abuse, we examined whether early cannabis exposure, in conjunction with polymorphic variation in the catechol-O-methyl transferase gene (COMT Val158Met), influences the risk for cocaine-induced paranoia (CIP). METHODS: Cannabis-use history was obtained in 1140 cocaine-dependent individuals from a family-based (affected sibling pair) study using the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA). Logistic regression and generalized estimating equations' analyses were used to examine the role of adolescent-onset cannabis use (< or =15 years of age) on CIP risk, both controlling for previously implicated CIP risk factors and familial relationships, and considering potential interactions with COMT Val158Met genotype. RESULTS: Cocaine-dependent individuals who endorsed CIP had significantly higher rates of adolescent-onset cannabis use than those without CIP (62.2% vs. 50.2%; chi(2)=15.2, df=1, p<0.0001), a finding that remained after controlling for sibling correlations and other risk factors. There were no effects of COMT genotype or genotype by early cannabis onset interactions. A modest (OR=1.4) and nearly significant (p=0.053) effect of CIP status in probands on CIP status in siblings was also noted. CONCLUSIONS: Adolescent-onset cannabis use increases the risk of CIP in cocaine-dependent individuals. COMT genotype and its interaction with early cannabis exposure did not emerge as significant predictors of CIP. In addition, trait vulnerability to CIP may also be familial in nature. SN - 1879-0046 UR - https://www.unboundmedicine.com/medline/citation/19944543/full_citation/Adolescent_cannabis_use_increases_risk_for_cocaine_induced_paranoia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0376-8716(09)00396-2 ER -