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Foodborne toxins of marine origin: ciguatera.
Rev Environ Contam Toxicol. 1991; 117:51-94.RE

Abstract

Ciguatera poisoning has long been recognized as a serious problem in the tropical and subtropical regions of the world. Due to international and interstate commerce and tourist travel the phenomenon is spreading to other parts of the globe. Various species of fish (surgeonfish, snapper, grouper, barracuda, jack, amberjack among others) have been implicated in this type of poisoning. These fish accumulate toxins in their flesh and viscera through the consumption of smaller fish that have been previously contaminated by feeding on toxic dinoflagellates. The most probable source of ciguatera is thought to be the benthic microorganism, Gambierdiscus toxicus, which produces both CTX and MTX, but other species of dinoflagellates such as Prorocentrum lima may also contribute with secondary toxins associated with the disease. Potentially ciguatoxic dinoflagellates have been isolated, cultured under laboratory conditions and dinoflagellate growth requirements as well as some factors affecting toxin production have been determined. Also, data from their ecological environment have been accumulated in an attempt to reveal a relationship with the epidemiology of ciguatera outbreaks. Several bioassays have been employed to determine the ciguatoxicity of fish. Cats have been used due to their sensitivity, but regurgitation has made dosage information difficult to obtain. Mongooses have also been used but they often carry parasitic and other type of diseases which complicate the bioassay. Mice have been used more commonly; they offer a more reliable model, can be easily housed, readily are dosed in several ways, and manifest diverse symptoms similar to human intoxications; but the amount of toxic extract needed, time consumed, complicated extraction techniques, and instrumentation involved limit the use of this assay commercially. Other bioassays have been explored including the brine shrimp, chicken, mosquito, crayfish nerve cord, guinea pig ileum, guinea pig atrium, and other histological preparations. All require elaborate time-consuming procedures, are not reproducible, lack specificity, and are semiquantitative at best. The techniques that appear to represent the major advance in identifying and detecting ciguatoxic fish are immunochemical methods: radioimmunoassay (RIA), competitive enzyme immunoassay (EIA), and enzyme-linked immunosorbent assay (ELISA). Of these, the enzyme immunoassay stick test is the simplest, fastest, most specific, more sensitive, and does not require complicated instrumentation.(

ABSTRACT

TRUNCATED AT 400 WORDS)

Authors+Show Affiliations

Department of Nutrition and Food Science, University of Arizona, Tucson 85721.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

1994459

Citation

Juranovic, L R., and D L. Park. "Foodborne Toxins of Marine Origin: Ciguatera." Reviews of Environmental Contamination and Toxicology, vol. 117, 1991, pp. 51-94.
Juranovic LR, Park DL. Foodborne toxins of marine origin: ciguatera. Rev Environ Contam Toxicol. 1991;117:51-94.
Juranovic, L. R., & Park, D. L. (1991). Foodborne toxins of marine origin: ciguatera. Reviews of Environmental Contamination and Toxicology, 117, 51-94.
Juranovic LR, Park DL. Foodborne Toxins of Marine Origin: Ciguatera. Rev Environ Contam Toxicol. 1991;117:51-94. PubMed PMID: 1994459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Foodborne toxins of marine origin: ciguatera. AU - Juranovic,L R, AU - Park,D L, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 51 EP - 94 JF - Reviews of environmental contamination and toxicology JO - Rev Environ Contam Toxicol VL - 117 N2 - Ciguatera poisoning has long been recognized as a serious problem in the tropical and subtropical regions of the world. Due to international and interstate commerce and tourist travel the phenomenon is spreading to other parts of the globe. Various species of fish (surgeonfish, snapper, grouper, barracuda, jack, amberjack among others) have been implicated in this type of poisoning. These fish accumulate toxins in their flesh and viscera through the consumption of smaller fish that have been previously contaminated by feeding on toxic dinoflagellates. The most probable source of ciguatera is thought to be the benthic microorganism, Gambierdiscus toxicus, which produces both CTX and MTX, but other species of dinoflagellates such as Prorocentrum lima may also contribute with secondary toxins associated with the disease. Potentially ciguatoxic dinoflagellates have been isolated, cultured under laboratory conditions and dinoflagellate growth requirements as well as some factors affecting toxin production have been determined. Also, data from their ecological environment have been accumulated in an attempt to reveal a relationship with the epidemiology of ciguatera outbreaks. Several bioassays have been employed to determine the ciguatoxicity of fish. Cats have been used due to their sensitivity, but regurgitation has made dosage information difficult to obtain. Mongooses have also been used but they often carry parasitic and other type of diseases which complicate the bioassay. Mice have been used more commonly; they offer a more reliable model, can be easily housed, readily are dosed in several ways, and manifest diverse symptoms similar to human intoxications; but the amount of toxic extract needed, time consumed, complicated extraction techniques, and instrumentation involved limit the use of this assay commercially. Other bioassays have been explored including the brine shrimp, chicken, mosquito, crayfish nerve cord, guinea pig ileum, guinea pig atrium, and other histological preparations. All require elaborate time-consuming procedures, are not reproducible, lack specificity, and are semiquantitative at best. The techniques that appear to represent the major advance in identifying and detecting ciguatoxic fish are immunochemical methods: radioimmunoassay (RIA), competitive enzyme immunoassay (EIA), and enzyme-linked immunosorbent assay (ELISA). Of these, the enzyme immunoassay stick test is the simplest, fastest, most specific, more sensitive, and does not require complicated instrumentation.(ABSTRACT TRUNCATED AT 400 WORDS) SN - 0179-5953 UR - https://www.unboundmedicine.com/medline/citation/1994459/Foodborne_toxins_of_marine_origin:_ciguatera_ L2 - https://medlineplus.gov/foodborneillness.html DB - PRIME DP - Unbound Medicine ER -