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Loss of maternal measles antibody in black South African infants in the first year of life--implications for age of vaccination.
S Afr Med J. 1991 Feb 02; 79(3):145-8.SA

Abstract

In order to investigate the feasibility of measles vaccination before the age of 9 months the duration of passive immunity against measles was estimated by conducting a longitudinal study of measles antibody levels in 20 black neonates delivered at term. Measles serum antibody (IgG) was measured by enzyme-linked immunosorbent assay in the mother at childbirth and on consecutive samples taken from the infants from birth until 9 months of age. Protective measles antibody level was defined as greater than 200 mIU. Unprotective levels were found in 88% (95% confidence interval (CI) 81-99%) of 6-month-old infants, while at 9 months all were susceptible. The mean antibody level was 192 mIU (CI 104-348%) at 4 months; 34 mIU (CI 15-73%) at 6 months and 13 mIU (CI 6-24%) at 9 months of age. Our data support the recent World Health Organisation recommendation to immunise children in developing countries at 6 months with the 'high titre' Edmonston-Zagreb measles vaccine, since most infants in our study had lost passive immunity against measles by this age.

Authors+Show Affiliations

Department of Paediatrics and Child Health, University of Natal, Durban.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1994484

Citation

Kiepiela, P, et al. "Loss of Maternal Measles Antibody in Black South African Infants in the First Year of Life--implications for Age of Vaccination." South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde, vol. 79, no. 3, 1991, pp. 145-8.
Kiepiela P, Coovadia HM, Loening WE, et al. Loss of maternal measles antibody in black South African infants in the first year of life--implications for age of vaccination. S Afr Med J. 1991;79(3):145-8.
Kiepiela, P., Coovadia, H. M., Loening, W. E., Coward, P., & Abdool Karim, S. S. (1991). Loss of maternal measles antibody in black South African infants in the first year of life--implications for age of vaccination. South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde, 79(3), 145-8.
Kiepiela P, et al. Loss of Maternal Measles Antibody in Black South African Infants in the First Year of Life--implications for Age of Vaccination. S Afr Med J. 1991 Feb 2;79(3):145-8. PubMed PMID: 1994484.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Loss of maternal measles antibody in black South African infants in the first year of life--implications for age of vaccination. AU - Kiepiela,P, AU - Coovadia,H M, AU - Loening,W E, AU - Coward,P, AU - Abdool Karim,S S, PY - 1991/2/2/pubmed PY - 1991/2/2/medline PY - 1991/2/2/entrez SP - 145 EP - 8 JF - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde JO - S Afr Med J VL - 79 IS - 3 N2 - In order to investigate the feasibility of measles vaccination before the age of 9 months the duration of passive immunity against measles was estimated by conducting a longitudinal study of measles antibody levels in 20 black neonates delivered at term. Measles serum antibody (IgG) was measured by enzyme-linked immunosorbent assay in the mother at childbirth and on consecutive samples taken from the infants from birth until 9 months of age. Protective measles antibody level was defined as greater than 200 mIU. Unprotective levels were found in 88% (95% confidence interval (CI) 81-99%) of 6-month-old infants, while at 9 months all were susceptible. The mean antibody level was 192 mIU (CI 104-348%) at 4 months; 34 mIU (CI 15-73%) at 6 months and 13 mIU (CI 6-24%) at 9 months of age. Our data support the recent World Health Organisation recommendation to immunise children in developing countries at 6 months with the 'high titre' Edmonston-Zagreb measles vaccine, since most infants in our study had lost passive immunity against measles by this age. SN - 0256-9574 UR - https://www.unboundmedicine.com/medline/citation/1994484/Loss_of_maternal_measles_antibody_in_black_South_African_infants_in_the_first_year_of_life__implications_for_age_of_vaccination_ DB - PRIME DP - Unbound Medicine ER -