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Management of schizophrenia with obesity, metabolic, and endocrinological disorders.
Psychiatr Clin North Am. 2009 Dec; 32(4):775-94.PC

Abstract

People with schizophrenia have an increased prevalence of overweight/obesity, type 2 diabetes mellitus, dyslipidemia, and metabolic syndrome, which increases the risk for cardiovascular diseases and mortality. Part of this increased risk is attributable to the use of antipsychotic medications, especially second-generation antipsychotics. Antipsychotic drugs differ in their potential to induce weight gain, with clozapine and olanzapine exhibiting the highest weight gain liability; evidence for differing effects of antipsychotics on glucose and lipid metabolism is less convincing. Individuals with schizophrenia may develop hyperprolactinemia, with or without clinical symptoms, after starting antipsychotic medications. This effect is particularly frequent with first-generation antipsychotics and with the second-generation antipsychotic risperidone and paliperidone. Psychiatrists should be aware of metabolic and endocrine side effects of antipsychotics and should make every effort to prevent or minimize them to improve the patients' compliance and quality of life.

Authors+Show Affiliations

Department of Psychiatry, University of Naples SUN, Naples, Largo Madonna delle Grazie, 80138, Napoli, Italy. monteri@tin.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19944883

Citation

Monteleone, Palmiero, et al. "Management of Schizophrenia With Obesity, Metabolic, and Endocrinological Disorders." The Psychiatric Clinics of North America, vol. 32, no. 4, 2009, pp. 775-94.
Monteleone P, Martiadis V, Maj M. Management of schizophrenia with obesity, metabolic, and endocrinological disorders. Psychiatr Clin North Am. 2009;32(4):775-94.
Monteleone, P., Martiadis, V., & Maj, M. (2009). Management of schizophrenia with obesity, metabolic, and endocrinological disorders. The Psychiatric Clinics of North America, 32(4), 775-94. https://doi.org/10.1016/j.psc.2009.08.003
Monteleone P, Martiadis V, Maj M. Management of Schizophrenia With Obesity, Metabolic, and Endocrinological Disorders. Psychiatr Clin North Am. 2009;32(4):775-94. PubMed PMID: 19944883.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Management of schizophrenia with obesity, metabolic, and endocrinological disorders. AU - Monteleone,Palmiero, AU - Martiadis,Vassilis, AU - Maj,Mario, PY - 2009/12/1/entrez PY - 2009/12/1/pubmed PY - 2010/2/19/medline SP - 775 EP - 94 JF - The Psychiatric clinics of North America JO - Psychiatr Clin North Am VL - 32 IS - 4 N2 - People with schizophrenia have an increased prevalence of overweight/obesity, type 2 diabetes mellitus, dyslipidemia, and metabolic syndrome, which increases the risk for cardiovascular diseases and mortality. Part of this increased risk is attributable to the use of antipsychotic medications, especially second-generation antipsychotics. Antipsychotic drugs differ in their potential to induce weight gain, with clozapine and olanzapine exhibiting the highest weight gain liability; evidence for differing effects of antipsychotics on glucose and lipid metabolism is less convincing. Individuals with schizophrenia may develop hyperprolactinemia, with or without clinical symptoms, after starting antipsychotic medications. This effect is particularly frequent with first-generation antipsychotics and with the second-generation antipsychotic risperidone and paliperidone. Psychiatrists should be aware of metabolic and endocrine side effects of antipsychotics and should make every effort to prevent or minimize them to improve the patients' compliance and quality of life. SN - 1558-3147 UR - https://www.unboundmedicine.com/medline/citation/19944883/Management_of_schizophrenia_with_obesity_metabolic_and_endocrinological_disorders_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0193-953X(09)00074-4 DB - PRIME DP - Unbound Medicine ER -