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[Allergic sensitization profile in 0-5 year old children with wheezing and/or atopic dermatitis].
An Pediatr (Barc). 2010 Jan; 72(1):30-41.AP

Abstract

BACKGROUND

Although allergic diseases are frequent in childhood, few studies have characterised the IgE sensitization profile among young children with allergic-like symptoms.

OBJECTIVE

To determine the prevalence and the type of allergic sensitization, as well as the demographic and environmental factors related to both characteristics, among 0-5 year old children presenting with wheezing and/or atopic dermatitis.

METHODS

Collaborative cross-over study developed in the paediatric setting of 20 Spanish Primary Health Care Centres. An allergology evaluation including blood determination of specific IgE antibodies to common inhalant and food allergens was performed on 468 children who presented with wheezing and/or atopic dermatitis.

RESULTS

Allergic sensitization was detected in 32.4% of the children with wheezing (95% confidence interval, 95%CI, 26.3-38.6%), in 54.8% of the children who had atopic dermatitis (95%CI, 42.1-67.6%) and in 39.2% of the children with both processes (95%CI, 32.0-46.4%). The risk of allergic sensitization was sex related (male versus female adjusted odds ratio, OR(A), 1.91, 95%CI, 1.24-2.95), and also related to the age (3-5 versus 0-2 year old OR(A) 1.96, 95%CI, 1.27-3.0), type of early feeding (maternal milk versus infant formula OR(A) 0.51, 95%CI, 0.31-0.84) and geoclimatic area (OR(A) Continental versus Atlantic 2.26, 95%CI, 1.30-3.93). Compared to the Atlantic area, the Continental area the sensitization was lower to mites (OR(A) 0.16, 95%CI, 0.07-0.36) and higher to grass (OR(A) 4.65, 95%CI 1.99-10.86), cow milk (OR(A) 5.17, 95%CI, 1.71-15.62) and egg (OR(A) 5.26, 95%CI, 2.04-13.62), whereas in the Mediterranean area the sensitization was lower to mites (OR(A) 0.29, 95%CI, 0.13-0.64) and higher to cow milk (OR(A) 3.81, 95%CI, 1.20-12.14) and egg (OR(A) 5.24, 95%CI, 1.94-14.20).

CONCLUSION

A significant proportion of small children treated at the paediatric primary health care centres due to wheezing and/or atopic dermatitis had allergic sensitization. There appears to be a geoclimatic variation in the prevalence of sensitization to inhalant and food allergens among young children with allergic like symptoms who live in Spain.

Authors+Show Affiliations

Centro de Salud La Ería, Oviedo, Asturias, España. icarvajalu@telefonica.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

spa

PubMed ID

19945364

Citation

Carvajal Urueña, I, et al. "[Allergic Sensitization Profile in 0-5 Year Old Children With Wheezing And/or Atopic Dermatitis]." Anales De Pediatria (Barcelona, Spain : 2003), vol. 72, no. 1, 2010, pp. 30-41.
Carvajal Urueña I, Díaz Vázquez C, Cano Garcinuño A, et al. [Allergic sensitization profile in 0-5 year old children with wheezing and/or atopic dermatitis]. An Pediatr (Barc). 2010;72(1):30-41.
Carvajal Urueña, I., Díaz Vázquez, C., Cano Garcinuño, A., García Merino, A., Morell Bernabé, J. J., Pascual Pérez, J. M., Jiménez Cortés, A., Blanco González, J., Montón Alvarez, J. L., Pérez Porcuna, X., Torregrosa Bertet, M. J., & Callén Blecua, M. (2010). [Allergic sensitization profile in 0-5 year old children with wheezing and/or atopic dermatitis]. Anales De Pediatria (Barcelona, Spain : 2003), 72(1), 30-41. https://doi.org/10.1016/j.anpedi.2009.09.011
Carvajal Urueña I, et al. [Allergic Sensitization Profile in 0-5 Year Old Children With Wheezing And/or Atopic Dermatitis]. An Pediatr (Barc). 2010;72(1):30-41. PubMed PMID: 19945364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Allergic sensitization profile in 0-5 year old children with wheezing and/or atopic dermatitis]. AU - Carvajal Urueña,I, AU - Díaz Vázquez,C, AU - Cano Garcinuño,A, AU - García Merino,A, AU - Morell Bernabé,J J, AU - Pascual Pérez,J M, AU - Jiménez Cortés,A, AU - Blanco González,J, AU - Montón Alvarez,J L, AU - Pérez Porcuna,X, AU - Torregrosa Bertet,M J, AU - Callén Blecua,M, AU - ,, Y1 - 2009/11/27/ PY - 2009/06/14/received PY - 2009/09/03/revised PY - 2009/09/28/accepted PY - 2009/12/1/entrez PY - 2009/12/1/pubmed PY - 2010/6/17/medline SP - 30 EP - 41 JF - Anales de pediatria (Barcelona, Spain : 2003) JO - An Pediatr (Barc) VL - 72 IS - 1 N2 - BACKGROUND: Although allergic diseases are frequent in childhood, few studies have characterised the IgE sensitization profile among young children with allergic-like symptoms. OBJECTIVE: To determine the prevalence and the type of allergic sensitization, as well as the demographic and environmental factors related to both characteristics, among 0-5 year old children presenting with wheezing and/or atopic dermatitis. METHODS: Collaborative cross-over study developed in the paediatric setting of 20 Spanish Primary Health Care Centres. An allergology evaluation including blood determination of specific IgE antibodies to common inhalant and food allergens was performed on 468 children who presented with wheezing and/or atopic dermatitis. RESULTS: Allergic sensitization was detected in 32.4% of the children with wheezing (95% confidence interval, 95%CI, 26.3-38.6%), in 54.8% of the children who had atopic dermatitis (95%CI, 42.1-67.6%) and in 39.2% of the children with both processes (95%CI, 32.0-46.4%). The risk of allergic sensitization was sex related (male versus female adjusted odds ratio, OR(A), 1.91, 95%CI, 1.24-2.95), and also related to the age (3-5 versus 0-2 year old OR(A) 1.96, 95%CI, 1.27-3.0), type of early feeding (maternal milk versus infant formula OR(A) 0.51, 95%CI, 0.31-0.84) and geoclimatic area (OR(A) Continental versus Atlantic 2.26, 95%CI, 1.30-3.93). Compared to the Atlantic area, the Continental area the sensitization was lower to mites (OR(A) 0.16, 95%CI, 0.07-0.36) and higher to grass (OR(A) 4.65, 95%CI 1.99-10.86), cow milk (OR(A) 5.17, 95%CI, 1.71-15.62) and egg (OR(A) 5.26, 95%CI, 2.04-13.62), whereas in the Mediterranean area the sensitization was lower to mites (OR(A) 0.29, 95%CI, 0.13-0.64) and higher to cow milk (OR(A) 3.81, 95%CI, 1.20-12.14) and egg (OR(A) 5.24, 95%CI, 1.94-14.20). CONCLUSION: A significant proportion of small children treated at the paediatric primary health care centres due to wheezing and/or atopic dermatitis had allergic sensitization. There appears to be a geoclimatic variation in the prevalence of sensitization to inhalant and food allergens among young children with allergic like symptoms who live in Spain. SN - 1695-9531 UR - https://www.unboundmedicine.com/medline/citation/19945364/[Allergic_sensitization_profile_in_0_5_year_old_children_with_wheezing_and/or_atopic_dermatitis]_ L2 - http://www.elsevier.es/en/linksolver/ft/pii/S1695-4033(09)00592-X DB - PRIME DP - Unbound Medicine ER -