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Relation between resting EEG to cognitive performance and clinical symptoms in adults with attention-deficit/hyperactivity disorder.

Abstract

Attention-deficit/hyperactivity disorder (ADHD) in children is characterized by elevated levels of slow wave activity and reduced fast wave activity in resting-state electroencephalogram (EEG). In adults with ADHD, resting-state EEG findings are scarce and inconsistent. The present study examined whether the disparate findings are due EEG recording conditions (i.e., eyes-open vs. eyes-closed). A second goal of the current study was to assess relations between EEG spectral indices to performance measures obtained using a stop-signal task, and to behavioral ADHD symptoms. The present study included 24 adults with ADHD and 24 control adults. The EEG results showed a greater reduction in alpha power from eyes-closed to eyes-open (i.e., alpha attenuation) in ADHD compared to controls. In addition, theta/beta ratio was negatively correlated to the speed of responding to choice stimuli. These findings were interpreted vis-à-vis a biophysical model assuming that the hypo-arousal in ADHD is due to an overdrive of the nucleus coeruleus resulting in inhibitory activity of the thalamic reticular nucleus.

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  • Authors+Show Affiliations

    ,

    Department of Psychiatry, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.

    , , , , ,

    Source

    Neuroscience letters 469:1 2010 Jan 18 pg 102-6

    MeSH

    Adolescent
    Adult
    Attention Deficit Disorder with Hyperactivity
    Brain
    Cognition
    Electroencephalography
    Female
    Humans
    Male
    Middle Aged
    Rest
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19945506

    Citation

    van Dongen-Boomsma, Martine, et al. "Relation Between Resting EEG to Cognitive Performance and Clinical Symptoms in Adults With Attention-deficit/hyperactivity Disorder." Neuroscience Letters, vol. 469, no. 1, 2010, pp. 102-6.
    van Dongen-Boomsma M, Lansbergen MM, Bekker EM, et al. Relation between resting EEG to cognitive performance and clinical symptoms in adults with attention-deficit/hyperactivity disorder. Neurosci Lett. 2010;469(1):102-6.
    van Dongen-Boomsma, M., Lansbergen, M. M., Bekker, E. M., Kooij, J. J., van der Molen, M., Kenemans, J. L., & Buitelaar, J. K. (2010). Relation between resting EEG to cognitive performance and clinical symptoms in adults with attention-deficit/hyperactivity disorder. Neuroscience Letters, 469(1), pp. 102-6. doi:10.1016/j.neulet.2009.11.053.
    van Dongen-Boomsma M, et al. Relation Between Resting EEG to Cognitive Performance and Clinical Symptoms in Adults With Attention-deficit/hyperactivity Disorder. Neurosci Lett. 2010 Jan 18;469(1):102-6. PubMed PMID: 19945506.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Relation between resting EEG to cognitive performance and clinical symptoms in adults with attention-deficit/hyperactivity disorder. AU - van Dongen-Boomsma,Martine, AU - Lansbergen,Marieke M, AU - Bekker,Evelijne M, AU - Kooij,J J Sandra, AU - van der Molen,Maurits, AU - Kenemans,J Leon, AU - Buitelaar,Jan K, Y1 - 2009/11/27/ PY - 2009/07/06/received PY - 2009/11/17/revised PY - 2009/11/21/accepted PY - 2009/12/1/entrez PY - 2009/12/1/pubmed PY - 2010/3/10/medline SP - 102 EP - 6 JF - Neuroscience letters JO - Neurosci. Lett. VL - 469 IS - 1 N2 - Attention-deficit/hyperactivity disorder (ADHD) in children is characterized by elevated levels of slow wave activity and reduced fast wave activity in resting-state electroencephalogram (EEG). In adults with ADHD, resting-state EEG findings are scarce and inconsistent. The present study examined whether the disparate findings are due EEG recording conditions (i.e., eyes-open vs. eyes-closed). A second goal of the current study was to assess relations between EEG spectral indices to performance measures obtained using a stop-signal task, and to behavioral ADHD symptoms. The present study included 24 adults with ADHD and 24 control adults. The EEG results showed a greater reduction in alpha power from eyes-closed to eyes-open (i.e., alpha attenuation) in ADHD compared to controls. In addition, theta/beta ratio was negatively correlated to the speed of responding to choice stimuli. These findings were interpreted vis-à-vis a biophysical model assuming that the hypo-arousal in ADHD is due to an overdrive of the nucleus coeruleus resulting in inhibitory activity of the thalamic reticular nucleus. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/19945506/Relation_between_resting_EEG_to_cognitive_performance_and_clinical_symptoms_in_adults_with_attention_deficit/hyperactivity_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(09)01544-4 DB - PRIME DP - Unbound Medicine ER -