Tags

Type your tag names separated by a space and hit enter

Relationship between bone mineral density, bone turnover markers and homocysteine, folate and vitamin B12 levels in postmenopausal women.

Abstract

PURPOSE

We aimed to investigate whether levels of homocysteine (Hcy), folate, and vitamin B12 are related to bone turnover markers and bone mineral density (BMD) in postmenopausal women.

METHODS

One hundred and twenty postmenopausal women were divided into three groups: osteoporotic, osteopenic and normal, according to the BMD measurements. The age, weight, body mass index (BMI), years since menopause (YSM), gravidity, parity, bone turnover markers [type I collagen C-telopeptides (CTx) and bone-specific alkaline phosphatase (BAP)], serum Hcy, parathyroid hormone (PTH), vitamin B12, folate, calcium and magnesium levels were compared with each other.

RESULTS

Twenty-five women had osteoporotic, 42 women had osteopenic, and 53 had normal BMD values. After adjusting for confounding factors, serum Hcy levels were significantly higher in osteoporotic women [adj OR = 38.95 (1.474-1029.88) p = 0.02]. The age, YSM, PTH, CTx and BAP levels were related to serum Hcy in all women (beta = 0.523, p = 0.0001; beta = 0.446, p = 0.001; beta = 0.295, p = 0.005; beta = 0.239, p = 0.026; beta = 0.451, p = 0.001, respectively).

CONCLUSIONS

Our data showed that vitamin B12, folate and Hcy levels were not related with BMD in postmenopausal women. We think that one of the underlying mechanisms of increased Hcy levels and osteoporosis may be a mechanistic link which cannot detected by BMD or biochemical markers.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Obstetrics and Gynecology, School of Medicine, Maltepe University, Istanbul, Turkey. bernadr23@hotmail.com

    , , , , ,

    Source

    MeSH

    Alkaline Phosphatase
    Biomarkers
    Bone Density
    Collagen Type I
    Female
    Folic Acid
    Homocysteine
    Humans
    Middle Aged
    Peptides
    Postmenopause
    Vitamin B 12

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19946695

    Citation

    Haliloglu, Berna, et al. "Relationship Between Bone Mineral Density, Bone Turnover Markers and Homocysteine, Folate and Vitamin B12 Levels in Postmenopausal Women." Archives of Gynecology and Obstetrics, vol. 281, no. 4, 2010, pp. 663-8.
    Haliloglu B, Aksungar FB, Ilter E, et al. Relationship between bone mineral density, bone turnover markers and homocysteine, folate and vitamin B12 levels in postmenopausal women. Arch Gynecol Obstet. 2010;281(4):663-8.
    Haliloglu, B., Aksungar, F. B., Ilter, E., Peker, H., Akin, F. T., Mutlu, N., & Ozekici, U. (2010). Relationship between bone mineral density, bone turnover markers and homocysteine, folate and vitamin B12 levels in postmenopausal women. Archives of Gynecology and Obstetrics, 281(4), pp. 663-8. doi:10.1007/s00404-009-1297-4.
    Haliloglu B, et al. Relationship Between Bone Mineral Density, Bone Turnover Markers and Homocysteine, Folate and Vitamin B12 Levels in Postmenopausal Women. Arch Gynecol Obstet. 2010;281(4):663-8. PubMed PMID: 19946695.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Relationship between bone mineral density, bone turnover markers and homocysteine, folate and vitamin B12 levels in postmenopausal women. AU - Haliloglu,Berna, AU - Aksungar,Fehime Benli, AU - Ilter,Erdin, AU - Peker,Hakan, AU - Akin,Figen Temelli, AU - Mutlu,Nilgun, AU - Ozekici,Umit, Y1 - 2009/11/28/ PY - 2009/09/23/received PY - 2009/11/12/accepted PY - 2009/12/1/entrez PY - 2009/12/1/pubmed PY - 2010/7/8/medline SP - 663 EP - 8 JF - Archives of gynecology and obstetrics JO - Arch. Gynecol. Obstet. VL - 281 IS - 4 N2 - PURPOSE: We aimed to investigate whether levels of homocysteine (Hcy), folate, and vitamin B12 are related to bone turnover markers and bone mineral density (BMD) in postmenopausal women. METHODS: One hundred and twenty postmenopausal women were divided into three groups: osteoporotic, osteopenic and normal, according to the BMD measurements. The age, weight, body mass index (BMI), years since menopause (YSM), gravidity, parity, bone turnover markers [type I collagen C-telopeptides (CTx) and bone-specific alkaline phosphatase (BAP)], serum Hcy, parathyroid hormone (PTH), vitamin B12, folate, calcium and magnesium levels were compared with each other. RESULTS: Twenty-five women had osteoporotic, 42 women had osteopenic, and 53 had normal BMD values. After adjusting for confounding factors, serum Hcy levels were significantly higher in osteoporotic women [adj OR = 38.95 (1.474-1029.88) p = 0.02]. The age, YSM, PTH, CTx and BAP levels were related to serum Hcy in all women (beta = 0.523, p = 0.0001; beta = 0.446, p = 0.001; beta = 0.295, p = 0.005; beta = 0.239, p = 0.026; beta = 0.451, p = 0.001, respectively). CONCLUSIONS: Our data showed that vitamin B12, folate and Hcy levels were not related with BMD in postmenopausal women. We think that one of the underlying mechanisms of increased Hcy levels and osteoporosis may be a mechanistic link which cannot detected by BMD or biochemical markers. SN - 1432-0711 UR - https://www.unboundmedicine.com/medline/citation/19946695/Relationship_between_bone_mineral_density_bone_turnover_markers_and_homocysteine_folate_and_vitamin_B12_levels_in_postmenopausal_women_ L2 - https://dx.doi.org/10.1007/s00404-009-1297-4 DB - PRIME DP - Unbound Medicine ER -