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Is moderate substance use associated with altered executive functioning in a population-based sample of young adults?
Hum Psychopharmacol 2009; 24(8):650-65HP

Abstract

BACKGROUND

Substance use (SU) has been linked with impaired cognitive functioning. Evidence comes mainly from clinical studies or studies examining heavy users. Though, the majority of users are not involved in heavy use. This study investigates the association between moderate use and cognition in a population-based sample.

METHODS

A total of 284 young adults with ecstasy, cannabis or alcohol use and a control group were sampled from the EDSP database for participation in the Munich Assessment of Young Adults (MAYA) study. Subjects completed a comprehensive battery of neuropsychological tests (executive functions, working memory and impulsivity). Multiple linear regression models were conducted to examine the relationship between use and cognitive performance.

RESULTS

Increased ecstasy consumption was associated with increased error-proneness (Stroop task, CANTAB ID/ED-shift, spatial working memory). More frequent cannabis use and more extensive alcohol consumption were associated with a higher degree of impulsiveness.

CONCLUSIONS

Based on mild to moderate SU, little indication of differences in executive functioning was found. For ecstasy use, an increased error-proneness was revealed. The subtle differences in relatively young individuals warrant further investigation in prospective long-term studies to identify subjects at risk, and to examine effects of prolonged patterns of use on executive functioning.

Authors+Show Affiliations

Ludwig Maximilian University, Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19946940

Citation

Piechatzek, Michaela, et al. "Is Moderate Substance Use Associated With Altered Executive Functioning in a Population-based Sample of Young Adults?" Human Psychopharmacology, vol. 24, no. 8, 2009, pp. 650-65.
Piechatzek M, Indlekofer F, Daamen M, et al. Is moderate substance use associated with altered executive functioning in a population-based sample of young adults? Hum Psychopharmacol. 2009;24(8):650-65.
Piechatzek, M., Indlekofer, F., Daamen, M., Glasmacher, C., Lieb, R., Pfister, H., ... Schütz, C. G. (2009). Is moderate substance use associated with altered executive functioning in a population-based sample of young adults? Human Psychopharmacology, 24(8), pp. 650-65. doi:10.1002/hup.1069.
Piechatzek M, et al. Is Moderate Substance Use Associated With Altered Executive Functioning in a Population-based Sample of Young Adults. Hum Psychopharmacol. 2009;24(8):650-65. PubMed PMID: 19946940.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is moderate substance use associated with altered executive functioning in a population-based sample of young adults? AU - Piechatzek,Michaela, AU - Indlekofer,Friedrich, AU - Daamen,Marcel, AU - Glasmacher,Christoph, AU - Lieb,Roselind, AU - Pfister,Hildegard, AU - Tucha,Oliver, AU - Lange,Klaus W, AU - Wittchen,Hans-Ulrich, AU - Schütz,Christian G, PY - 2009/12/1/entrez PY - 2009/12/1/pubmed PY - 2010/2/19/medline SP - 650 EP - 65 JF - Human psychopharmacology JO - Hum Psychopharmacol VL - 24 IS - 8 N2 - BACKGROUND: Substance use (SU) has been linked with impaired cognitive functioning. Evidence comes mainly from clinical studies or studies examining heavy users. Though, the majority of users are not involved in heavy use. This study investigates the association between moderate use and cognition in a population-based sample. METHODS: A total of 284 young adults with ecstasy, cannabis or alcohol use and a control group were sampled from the EDSP database for participation in the Munich Assessment of Young Adults (MAYA) study. Subjects completed a comprehensive battery of neuropsychological tests (executive functions, working memory and impulsivity). Multiple linear regression models were conducted to examine the relationship between use and cognitive performance. RESULTS: Increased ecstasy consumption was associated with increased error-proneness (Stroop task, CANTAB ID/ED-shift, spatial working memory). More frequent cannabis use and more extensive alcohol consumption were associated with a higher degree of impulsiveness. CONCLUSIONS: Based on mild to moderate SU, little indication of differences in executive functioning was found. For ecstasy use, an increased error-proneness was revealed. The subtle differences in relatively young individuals warrant further investigation in prospective long-term studies to identify subjects at risk, and to examine effects of prolonged patterns of use on executive functioning. SN - 1099-1077 UR - https://www.unboundmedicine.com/medline/citation/19946940/full_citation/Is_moderate_substance_use L2 - https://doi.org/10.1002/hup.1069 DB - PRIME DP - Unbound Medicine ER -