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Is moderate substance use associated with altered executive functioning in a population-based sample of young adults?

Abstract

BACKGROUND

Substance use (SU) has been linked with impaired cognitive functioning. Evidence comes mainly from clinical studies or studies examining heavy users. Though, the majority of users are not involved in heavy use. This study investigates the association between moderate use and cognition in a population-based sample.

METHODS

A total of 284 young adults with ecstasy, cannabis or alcohol use and a control group were sampled from the EDSP database for participation in the Munich Assessment of Young Adults (MAYA) study. Subjects completed a comprehensive battery of neuropsychological tests (executive functions, working memory and impulsivity). Multiple linear regression models were conducted to examine the relationship between use and cognitive performance.

RESULTS

Increased ecstasy consumption was associated with increased error-proneness (Stroop task, CANTAB ID/ED-shift, spatial working memory). More frequent cannabis use and more extensive alcohol consumption were associated with a higher degree of impulsiveness.

CONCLUSIONS

Based on mild to moderate SU, little indication of differences in executive functioning was found. For ecstasy use, an increased error-proneness was revealed. The subtle differences in relatively young individuals warrant further investigation in prospective long-term studies to identify subjects at risk, and to examine effects of prolonged patterns of use on executive functioning.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Ludwig Maximilian University, Munich, Germany.

    , , , , , , , ,

    Source

    Human psychopharmacology 24:8 2009 Dec pg 650-65

    MeSH

    Adult
    Alcohol Drinking
    Cognition Disorders
    Databases, Factual
    Executive Function
    Female
    Humans
    Impulsive Behavior
    Linear Models
    Male
    Marijuana Abuse
    Memory, Short-Term
    N-Methyl-3,4-methylenedioxyamphetamine
    Neuropsychological Tests
    Substance-Related Disorders
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19946940

    Citation

    TY - JOUR T1 - Is moderate substance use associated with altered executive functioning in a population-based sample of young adults? AU - Piechatzek,Michaela, AU - Indlekofer,Friedrich, AU - Daamen,Marcel, AU - Glasmacher,Christoph, AU - Lieb,Roselind, AU - Pfister,Hildegard, AU - Tucha,Oliver, AU - Lange,Klaus W, AU - Wittchen,Hans-Ulrich, AU - Schütz,Christian G, PY - 2009/12/1/entrez PY - 2009/12/1/pubmed PY - 2010/2/19/medline SP - 650 EP - 65 JF - Human psychopharmacology JO - Hum Psychopharmacol VL - 24 IS - 8 N2 - BACKGROUND: Substance use (SU) has been linked with impaired cognitive functioning. Evidence comes mainly from clinical studies or studies examining heavy users. Though, the majority of users are not involved in heavy use. This study investigates the association between moderate use and cognition in a population-based sample. METHODS: A total of 284 young adults with ecstasy, cannabis or alcohol use and a control group were sampled from the EDSP database for participation in the Munich Assessment of Young Adults (MAYA) study. Subjects completed a comprehensive battery of neuropsychological tests (executive functions, working memory and impulsivity). Multiple linear regression models were conducted to examine the relationship between use and cognitive performance. RESULTS: Increased ecstasy consumption was associated with increased error-proneness (Stroop task, CANTAB ID/ED-shift, spatial working memory). More frequent cannabis use and more extensive alcohol consumption were associated with a higher degree of impulsiveness. CONCLUSIONS: Based on mild to moderate SU, little indication of differences in executive functioning was found. For ecstasy use, an increased error-proneness was revealed. The subtle differences in relatively young individuals warrant further investigation in prospective long-term studies to identify subjects at risk, and to examine effects of prolonged patterns of use on executive functioning. SN - 1099-1077 UR - https://www.unboundmedicine.com/medline/citation/19946940/full_citation/Is_moderate_substance_use_associated_with_altered_executive_functioning_in_a_population_based_sample_of_young_adults L2 - https://doi.org/10.1002/hup.1069 ER -