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Injectable biodegradable thermosensitive hydrogel composite for orthopedic tissue engineering. 1. Preparation and characterization of nanohydroxyapatite/poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) hydrogel nanocomposites.
J Phys Chem B 2009; 113(52):16518-25JP

Abstract

In this study, we synthesized a biodegradable triblock copolymer poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG, PECE) by ring-opening copolymerization, and nanohydroxyapatite (n-HA) powder was prepared by a hydrothermal precipitation method. The obtained n-HA was incorporated into the PECE matrix to prepare injectable thermosensitive hydrogel nanocomposites. (1)H NMR, FT-IR, XRD, DSC, and TEM were used to investigate the properties of PECE copolymer and n-HA/PECE nanocomposites. The rheological measurements for n-HA/PECE nanocomposites revealed that the gelation temperature was approximately 36 degrees C. The sol-gel-sol transition behavior and phase transition diagrams were recorded through a test tube inverting method. The results showed that n-HA/PECE nanocomposites still had thermoresponsivity like that of PECE thermosensitive hydrogel. The morphology of the nanocomposites was observed by SEM; the results showed that the nanocomposites had a 3D network structure. In addition, the effects of n-HA contents on the properties of n-HA/PECE nanocomposites are also discussed in the paper. From the results, n-HA/PECE hydrogel is believed to be promising for injectable orthopedic tissue engineering due to its good thermosensitivity and injectability.

Authors+Show Affiliations

State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19947637

Citation

Fu, Shaozhi, et al. "Injectable Biodegradable Thermosensitive Hydrogel Composite for Orthopedic Tissue Engineering. 1. Preparation and Characterization of Nanohydroxyapatite/poly(ethylene Glycol)-poly(epsilon-caprolactone)-poly(ethylene Glycol) Hydrogel Nanocomposites." The Journal of Physical Chemistry. B, vol. 113, no. 52, 2009, pp. 16518-25.
Fu S, Guo G, Gong C, et al. Injectable biodegradable thermosensitive hydrogel composite for orthopedic tissue engineering. 1. Preparation and characterization of nanohydroxyapatite/poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) hydrogel nanocomposites. J Phys Chem B. 2009;113(52):16518-25.
Fu, S., Guo, G., Gong, C., Zeng, S., Liang, H., Luo, F., ... Qian, Z. (2009). Injectable biodegradable thermosensitive hydrogel composite for orthopedic tissue engineering. 1. Preparation and characterization of nanohydroxyapatite/poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) hydrogel nanocomposites. The Journal of Physical Chemistry. B, 113(52), pp. 16518-25. doi:10.1021/jp907974d.
Fu S, et al. Injectable Biodegradable Thermosensitive Hydrogel Composite for Orthopedic Tissue Engineering. 1. Preparation and Characterization of Nanohydroxyapatite/poly(ethylene Glycol)-poly(epsilon-caprolactone)-poly(ethylene Glycol) Hydrogel Nanocomposites. J Phys Chem B. 2009 Dec 31;113(52):16518-25. PubMed PMID: 19947637.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Injectable biodegradable thermosensitive hydrogel composite for orthopedic tissue engineering. 1. Preparation and characterization of nanohydroxyapatite/poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) hydrogel nanocomposites. AU - Fu,Shaozhi, AU - Guo,Gang, AU - Gong,Changyang, AU - Zeng,Shi, AU - Liang,Hang, AU - Luo,Feng, AU - Zhang,Xiaoning, AU - Zhao,Xia, AU - Wei,Yuquan, AU - Qian,Zhiyong, PY - 2009/12/2/entrez PY - 2009/12/2/pubmed PY - 2010/2/19/medline SP - 16518 EP - 25 JF - The journal of physical chemistry. B JO - J Phys Chem B VL - 113 IS - 52 N2 - In this study, we synthesized a biodegradable triblock copolymer poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG, PECE) by ring-opening copolymerization, and nanohydroxyapatite (n-HA) powder was prepared by a hydrothermal precipitation method. The obtained n-HA was incorporated into the PECE matrix to prepare injectable thermosensitive hydrogel nanocomposites. (1)H NMR, FT-IR, XRD, DSC, and TEM were used to investigate the properties of PECE copolymer and n-HA/PECE nanocomposites. The rheological measurements for n-HA/PECE nanocomposites revealed that the gelation temperature was approximately 36 degrees C. The sol-gel-sol transition behavior and phase transition diagrams were recorded through a test tube inverting method. The results showed that n-HA/PECE nanocomposites still had thermoresponsivity like that of PECE thermosensitive hydrogel. The morphology of the nanocomposites was observed by SEM; the results showed that the nanocomposites had a 3D network structure. In addition, the effects of n-HA contents on the properties of n-HA/PECE nanocomposites are also discussed in the paper. From the results, n-HA/PECE hydrogel is believed to be promising for injectable orthopedic tissue engineering due to its good thermosensitivity and injectability. SN - 1520-5207 UR - https://www.unboundmedicine.com/medline/citation/19947637/Injectable_biodegradable_thermosensitive_hydrogel_composite_for_orthopedic_tissue_engineering__1__Preparation_and_characterization_of_nanohydroxyapatite/poly_ethylene_glycol__poly_epsilon_caprolactone__poly_ethylene_glycol__hydrogel_nanocomposites_ L2 - https://dx.doi.org/10.1021/jp907974d DB - PRIME DP - Unbound Medicine ER -