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Photostabilization effect of quercetin on the UV filter combination, butyl methoxydibenzoylmethane-octyl methoxycinnamate.
Photochem Photobiol. 2010 Mar-Apr; 86(2):273-8.PP

Abstract

The aim of the study was to investigate the effect of the natural antioxidant quercetin on the photostability of the most widely used combination of UVA (320-400 nm) and UVB (290-320 nm) filters, respectively butyl methoxydibenzoylmethane (BMDBM) and octyl methoxycinnamate (OMC). In order to reproduce the conditions prevalent in commercial sunscreen products, the stabilizing efficacy of quercetin was evaluated in model creams containing BMDBM (3%, wt/wt) together with OMC (4%, wt/wt) and exposed to a solar simulator at an irradiance corresponding to natural sunlight. Quercetin was found to enhance the photostability of the two UV filters in a concentration-dependent way. Addition of quercetin to the sunscreen formulation significantly reduced the photodegradation of BMDBM and OMC from 40.3 +/- 2.4 to 27.7 +/- 2.6% and from 51.3 +/- 2.1 to 42.2 +/- 2.0%, respectively. Moreover, comparative photodegradation studies demonstrated that quercetin was much more effective and at a lower concentration than commonly used stabilizer (octocrylene) and antioxidants (vitamin E, butylated hydroxyanisole). In vitro determination of the UVB and UVA protection parameters showed that the quercetin-based formulation fulfilled the official requirements on sunscreen products. Because of its photostabilizing and multiple antioxidant properties, quercetin represents a useful additive for the formulation of effective broad-spectrum sunscreens containing BMDBM and OMC.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy. sls@unife.itNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19947972

Citation

Scalia, Santo, and Matteo Mezzena. "Photostabilization Effect of Quercetin On the UV Filter Combination, Butyl Methoxydibenzoylmethane-octyl Methoxycinnamate." Photochemistry and Photobiology, vol. 86, no. 2, 2010, pp. 273-8.
Scalia S, Mezzena M. Photostabilization effect of quercetin on the UV filter combination, butyl methoxydibenzoylmethane-octyl methoxycinnamate. Photochem Photobiol. 2010;86(2):273-8.
Scalia, S., & Mezzena, M. (2010). Photostabilization effect of quercetin on the UV filter combination, butyl methoxydibenzoylmethane-octyl methoxycinnamate. Photochemistry and Photobiology, 86(2), 273-8. https://doi.org/10.1111/j.1751-1097.2009.00655.x
Scalia S, Mezzena M. Photostabilization Effect of Quercetin On the UV Filter Combination, Butyl Methoxydibenzoylmethane-octyl Methoxycinnamate. Photochem Photobiol. 2010 Mar-Apr;86(2):273-8. PubMed PMID: 19947972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Photostabilization effect of quercetin on the UV filter combination, butyl methoxydibenzoylmethane-octyl methoxycinnamate. AU - Scalia,Santo, AU - Mezzena,Matteo, Y1 - 2009/11/23/ PY - 2009/12/2/entrez PY - 2009/12/2/pubmed PY - 2010/8/28/medline SP - 273 EP - 8 JF - Photochemistry and photobiology JO - Photochem Photobiol VL - 86 IS - 2 N2 - The aim of the study was to investigate the effect of the natural antioxidant quercetin on the photostability of the most widely used combination of UVA (320-400 nm) and UVB (290-320 nm) filters, respectively butyl methoxydibenzoylmethane (BMDBM) and octyl methoxycinnamate (OMC). In order to reproduce the conditions prevalent in commercial sunscreen products, the stabilizing efficacy of quercetin was evaluated in model creams containing BMDBM (3%, wt/wt) together with OMC (4%, wt/wt) and exposed to a solar simulator at an irradiance corresponding to natural sunlight. Quercetin was found to enhance the photostability of the two UV filters in a concentration-dependent way. Addition of quercetin to the sunscreen formulation significantly reduced the photodegradation of BMDBM and OMC from 40.3 +/- 2.4 to 27.7 +/- 2.6% and from 51.3 +/- 2.1 to 42.2 +/- 2.0%, respectively. Moreover, comparative photodegradation studies demonstrated that quercetin was much more effective and at a lower concentration than commonly used stabilizer (octocrylene) and antioxidants (vitamin E, butylated hydroxyanisole). In vitro determination of the UVB and UVA protection parameters showed that the quercetin-based formulation fulfilled the official requirements on sunscreen products. Because of its photostabilizing and multiple antioxidant properties, quercetin represents a useful additive for the formulation of effective broad-spectrum sunscreens containing BMDBM and OMC. SN - 1751-1097 UR - https://www.unboundmedicine.com/medline/citation/19947972/Photostabilization_effect_of_quercetin_on_the_UV_filter_combination_butyl_methoxydibenzoylmethane_octyl_methoxycinnamate_ L2 - https://doi.org/10.1111/j.1751-1097.2009.00655.x DB - PRIME DP - Unbound Medicine ER -