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Successful treatment with Yokukansan for behavioral and psychological symptoms of Parkinsonian dementia.
Prog Neuropsychopharmacol Biol Psychiatry. 2010 Mar 17; 34(2):284-7.PN

Abstract

OBJECTIVE

To evaluate the efficacy and safety of Yokukansan, a traditional Chinese herbal medicine, for treating behavioral and psychological symptoms of dementia (BPSD) in patients with Parkinson disease (PD; n=7) and those with PD with dementia (PDD; n=7).

BACKGROUND

BPSD are often seen in patients with senile dementia and have serious deleterious effects on the lives of patients and caregivers. Recent studies indicate that the traditional Chinese herbal medicine Yokukansan may be safe and beneficial for the treatment of BPSD patients.

METHODS

We treated 7 PD and 7 PDD patients for 4 weeks with Yokukansan and observed them without Yokukansan for 4 weeks. Changes in behavioral and psychological symptoms were evaluated every 4 weeks according to the Neuropsychiatric Inventory (NPI) scale.

RESULTS

Significant improvements in behavioral and psychological symptoms, particularly in the incidence and duration of hallucinations, were observed in most PD and PDD patients after 4 weeks of Yokukansan treatment. No significant changes were observed in the laboratory tests, cognitive function, activities of daily living, or parkinsonism.

CONCLUSION

Our results suggest that Yokukansan improves BPSD in both PD and PDD patients without worsening their cognitive function, ability to perform activities of daily living, or parkinsonism.

Authors+Show Affiliations

Department of Neurology, Juntendo Urayasu Hospital, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19948198

Citation

Kawanabe, Tadaaki, et al. "Successful Treatment With Yokukansan for Behavioral and Psychological Symptoms of Parkinsonian Dementia." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 34, no. 2, 2010, pp. 284-7.
Kawanabe T, Yoritaka A, Shimura H, et al. Successful treatment with Yokukansan for behavioral and psychological symptoms of Parkinsonian dementia. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(2):284-7.
Kawanabe, T., Yoritaka, A., Shimura, H., Oizumi, H., Tanaka, S., & Hattori, N. (2010). Successful treatment with Yokukansan for behavioral and psychological symptoms of Parkinsonian dementia. Progress in Neuro-psychopharmacology & Biological Psychiatry, 34(2), 284-7. https://doi.org/10.1016/j.pnpbp.2009.11.019
Kawanabe T, et al. Successful Treatment With Yokukansan for Behavioral and Psychological Symptoms of Parkinsonian Dementia. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Mar 17;34(2):284-7. PubMed PMID: 19948198.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Successful treatment with Yokukansan for behavioral and psychological symptoms of Parkinsonian dementia. AU - Kawanabe,Tadaaki, AU - Yoritaka,Asako, AU - Shimura,Hideki, AU - Oizumi,Hideki, AU - Tanaka,Shigeki, AU - Hattori,Nobutaka, Y1 - 2009/12/03/ PY - 2009/09/09/received PY - 2009/11/23/revised PY - 2009/11/23/accepted PY - 2009/12/2/entrez PY - 2009/12/2/pubmed PY - 2010/5/14/medline SP - 284 EP - 7 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 34 IS - 2 N2 - OBJECTIVE: To evaluate the efficacy and safety of Yokukansan, a traditional Chinese herbal medicine, for treating behavioral and psychological symptoms of dementia (BPSD) in patients with Parkinson disease (PD; n=7) and those with PD with dementia (PDD; n=7). BACKGROUND: BPSD are often seen in patients with senile dementia and have serious deleterious effects on the lives of patients and caregivers. Recent studies indicate that the traditional Chinese herbal medicine Yokukansan may be safe and beneficial for the treatment of BPSD patients. METHODS: We treated 7 PD and 7 PDD patients for 4 weeks with Yokukansan and observed them without Yokukansan for 4 weeks. Changes in behavioral and psychological symptoms were evaluated every 4 weeks according to the Neuropsychiatric Inventory (NPI) scale. RESULTS: Significant improvements in behavioral and psychological symptoms, particularly in the incidence and duration of hallucinations, were observed in most PD and PDD patients after 4 weeks of Yokukansan treatment. No significant changes were observed in the laboratory tests, cognitive function, activities of daily living, or parkinsonism. CONCLUSION: Our results suggest that Yokukansan improves BPSD in both PD and PDD patients without worsening their cognitive function, ability to perform activities of daily living, or parkinsonism. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/19948198/Successful_treatment_with_Yokukansan_for_behavioral_and_psychological_symptoms_of_Parkinsonian_dementia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(09)00405-9 DB - PRIME DP - Unbound Medicine ER -