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Prenatal di(2-ethylhexyl)phthalate exposure and length of gestation among an inner-city cohort.

Abstract

OBJECTIVE

Our objective was to assess the relationship between di(2-ethylhexyl)phthalate (DEHP) exposure during pregnancy and gestational age at delivery among 311 African American or Dominican women from New York City.

METHODS

Forty-eight-hour personal air and/or spot urine samples were collected during the third trimester. DEHP levels were measured in air samples and 4 DEHP metabolite levels were measured in urine. Specific gravity was used to adjust for urinary dilution. Gestational age was abstracted from newborn medical records (n = 289) or calculated from the expected date of delivery (n = 42). Multivariate linear regression models controlled for potential confounders.

RESULTS

DEHP was detected in 100% of personal air samples (geometric mean: 0.20 microg/m(3) [95% confidence interval [CI]: 0.18-0.21 microg/m(3)]); natural logarithms of air concentrations were inversely but not significantly associated with gestational age. Two or more of the DEHP metabolites were detected in 100% of urine samples (geometric mean: 4.8-38.9 ng/mL [95% CI: 4.1-44.3 ng/mL]). Controlling for potential confounders, gestational age was shorter by 1.1 days (95% CI: 0.2-1.8 days) for each 1-logarithmic unit increase in specific gravity-adjusted mono(2-ethylhexyl)phthalate concentrations (P = .01) and averaged 5.0 days (95% CI: 2.1-8.0 days) less among subjects with the highest versus lowest quartile concentrations (P = .001). Results were similar and statistically significant for the other DEHP metabolites.

CONCLUSIONS

Prenatal DEHP exposure was associated with shorter gestation but, given inconsistencies with previous findings for other study populations, results should be interpreted with caution, and additional research is warranted.

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  • Authors+Show Affiliations

    ,

    Columbia Center for Children's Environmental Health, Mailman School of Public Health, Columbia University, New York, NY 10032, USA. rmw5@columbia.edu

    , , , , , , , , , ,

    Source

    Pediatrics 124:6 2009 Dec pg e1213-20

    MeSH

    Adult
    African Americans
    Air Pollutants
    Diethylhexyl Phthalate
    Dominican Republic
    Environmental Monitoring
    Female
    Gestational Age
    Hispanic Americans
    Humans
    Infant, Newborn
    Labor Onset
    Multivariate Analysis
    New York City
    Plasticizers
    Pregnancy
    Statistics as Topic
    Urban Population

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, Non-P.H.S.

    Language

    eng

    PubMed ID

    19948620

    Citation

    * When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prenatal di(2-ethylhexyl)phthalate exposure and length of gestation among an inner-city cohort. AU - Whyatt,Robin M, AU - Adibi,Jennifer J, AU - Calafat,Antonia M, AU - Camann,David E, AU - Rauh,Virgina, AU - Bhat,Hari K, AU - Perera,Frederica P, AU - Andrews,Howard, AU - Just,Allan C, AU - Hoepner,Lori, AU - Tang,Deliang, AU - Hauser,Russ, PY - 2009/12/2/entrez PY - 2009/12/2/pubmed PY - 2009/12/31/medline SP - e1213 EP - 20 JF - Pediatrics JO - Pediatrics VL - 124 IS - 6 N2 - OBJECTIVE: Our objective was to assess the relationship between di(2-ethylhexyl)phthalate (DEHP) exposure during pregnancy and gestational age at delivery among 311 African American or Dominican women from New York City. METHODS: Forty-eight-hour personal air and/or spot urine samples were collected during the third trimester. DEHP levels were measured in air samples and 4 DEHP metabolite levels were measured in urine. Specific gravity was used to adjust for urinary dilution. Gestational age was abstracted from newborn medical records (n = 289) or calculated from the expected date of delivery (n = 42). Multivariate linear regression models controlled for potential confounders. RESULTS: DEHP was detected in 100% of personal air samples (geometric mean: 0.20 microg/m(3) [95% confidence interval [CI]: 0.18-0.21 microg/m(3)]); natural logarithms of air concentrations were inversely but not significantly associated with gestational age. Two or more of the DEHP metabolites were detected in 100% of urine samples (geometric mean: 4.8-38.9 ng/mL [95% CI: 4.1-44.3 ng/mL]). Controlling for potential confounders, gestational age was shorter by 1.1 days (95% CI: 0.2-1.8 days) for each 1-logarithmic unit increase in specific gravity-adjusted mono(2-ethylhexyl)phthalate concentrations (P = .01) and averaged 5.0 days (95% CI: 2.1-8.0 days) less among subjects with the highest versus lowest quartile concentrations (P = .001). Results were similar and statistically significant for the other DEHP metabolites. CONCLUSIONS: Prenatal DEHP exposure was associated with shorter gestation but, given inconsistencies with previous findings for other study populations, results should be interpreted with caution, and additional research is warranted. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/19948620/abstract/Prenatal_Di_2_ethylhexyl_Phthalate_Exposure_and_Length_of_Gestation_Among_an_Inner_City_Cohort L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=19948620 DB - PRIME DP - Unbound Medicine ER -