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Prevalence of Down syndrome among children and adolescents in 10 regions of the United States.
Pediatrics. 2009 Dec; 124(6):1565-71.Ped

Abstract

OBJECTIVE

We aimed to estimate the prevalence of Down syndrome (DS) among children and adolescents aged 0 to 19 years in 10 regions of the United States.

METHODS

This study was a cross-sectional analysis of live-born infants with DS during 1979-2003 from 10 population-based birth defects registries in the United States. We estimated the prevalence of DS at birth and among children aged 0 to 19 years in each region and in all regions pooled. The prevalence of DS among children and adolescents was calculated overall and according to age group, race/ethnicity, infant gender, and presence of a major heart defect.

RESULTS

From 1979 through 2003, the prevalence of DS at birth increased by 31.1%, from 9.0 to 11.8 per 10000 live births in 10 US regions. In 2002, the prevalence among children and adolescents (0-19 years old) was 10.3 per 10000. The prevalence of DS among children in a given age group consistently increased over time but decreased with age within a given birth cohort. The pooled prevalence of DS among children and adolescents was lower among non-Hispanic black individuals and other racial/ethnic groups compared with non-Hispanic white individuals; it was also lower among females than males.

CONCLUSIONS

This study provides prevalence estimates of DS among children and adolescents from 10 US regions. These estimates varied according to region, race/ethnicity, and gender, suggesting possible variation in prevalence at birth or in survival rates on the basis of these characteristics.

Authors+Show Affiliations

Division of Birth Defects and Developmental Disabilities, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. mshin@cdc.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19948627

Citation

Shin, Mikyong, et al. "Prevalence of Down Syndrome Among Children and Adolescents in 10 Regions of the United States." Pediatrics, vol. 124, no. 6, 2009, pp. 1565-71.
Shin M, Besser LM, Kucik JE, et al. Prevalence of Down syndrome among children and adolescents in 10 regions of the United States. Pediatrics. 2009;124(6):1565-71.
Shin, M., Besser, L. M., Kucik, J. E., Lu, C., Siffel, C., & Correa, A. (2009). Prevalence of Down syndrome among children and adolescents in 10 regions of the United States. Pediatrics, 124(6), 1565-71. https://doi.org/10.1542/peds.2009-0745
Shin M, et al. Prevalence of Down Syndrome Among Children and Adolescents in 10 Regions of the United States. Pediatrics. 2009;124(6):1565-71. PubMed PMID: 19948627.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of Down syndrome among children and adolescents in 10 regions of the United States. AU - Shin,Mikyong, AU - Besser,Lilah M, AU - Kucik,James E, AU - Lu,Chengxing, AU - Siffel,Csaba, AU - Correa,Adolfo, AU - ,, PY - 2009/12/2/entrez PY - 2009/12/2/pubmed PY - 2009/12/31/medline SP - 1565 EP - 71 JF - Pediatrics JO - Pediatrics VL - 124 IS - 6 N2 - OBJECTIVE: We aimed to estimate the prevalence of Down syndrome (DS) among children and adolescents aged 0 to 19 years in 10 regions of the United States. METHODS: This study was a cross-sectional analysis of live-born infants with DS during 1979-2003 from 10 population-based birth defects registries in the United States. We estimated the prevalence of DS at birth and among children aged 0 to 19 years in each region and in all regions pooled. The prevalence of DS among children and adolescents was calculated overall and according to age group, race/ethnicity, infant gender, and presence of a major heart defect. RESULTS: From 1979 through 2003, the prevalence of DS at birth increased by 31.1%, from 9.0 to 11.8 per 10000 live births in 10 US regions. In 2002, the prevalence among children and adolescents (0-19 years old) was 10.3 per 10000. The prevalence of DS among children in a given age group consistently increased over time but decreased with age within a given birth cohort. The pooled prevalence of DS among children and adolescents was lower among non-Hispanic black individuals and other racial/ethnic groups compared with non-Hispanic white individuals; it was also lower among females than males. CONCLUSIONS: This study provides prevalence estimates of DS among children and adolescents from 10 US regions. These estimates varied according to region, race/ethnicity, and gender, suggesting possible variation in prevalence at birth or in survival rates on the basis of these characteristics. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/19948627/Prevalence_of_Down_syndrome_among_children_and_adolescents_in_10_regions_of_the_United_States_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=19948627 DB - PRIME DP - Unbound Medicine ER -