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Coexistent atypical polypoid adenomyoma and complex atypical endometrial hyperplasia in the uterus.
Diagn Cytopathol. 2010 Jul; 38(7):527-32.DC

Abstract

We report a case of atypical polypoid adenomyoma (APA) concomitantly identified with complex atypical endometrial hyperplasia (CAH) in the uterus. Since an initial endometrial smear revealed atypical endometrial cells, a diagnosis of CAH was made. Even though a concomitantly performed uterine cervical smear contained both atypical epithelial and stromal cells, the diagnosis of APA was not initially made because the cytological criteria for APA had not been established. Histologically, we recognized both CAH in the uterine corpus and APA in the lower uterine segment in the hysterectomy material. Retrospectively, the cells in the first cervical smear were interpreted as part of APA because the same types of cells were observed in the intraoperative cytology sample. Although the APA and CAH lesions were interposed by normal endometrium, estrogen was suspected to be the common etiological factor. Reports regarding the cytology of APA are currently scarce. To our knowledge, this is the first report showing cytological presentation of association of APA with CAH in addition to the first cervical smear of APA containing both epithelial and stromal components. Identification of abnormal proliferation of epithelium and stromal cells of smooth muscle origin is useful in the cytological diagnosis of APA.

Authors+Show Affiliations

Department of Pathology, Kyorin University School of Medicine, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19950396

Citation

Horita, Ayako, et al. "Coexistent Atypical Polypoid Adenomyoma and Complex Atypical Endometrial Hyperplasia in the Uterus." Diagnostic Cytopathology, vol. 38, no. 7, 2010, pp. 527-32.
Horita A, Kurata A, Komatsu K, et al. Coexistent atypical polypoid adenomyoma and complex atypical endometrial hyperplasia in the uterus. Diagn Cytopathol. 2010;38(7):527-32.
Horita, A., Kurata, A., Komatsu, K., Yajima, M., & Sakamoto, A. (2010). Coexistent atypical polypoid adenomyoma and complex atypical endometrial hyperplasia in the uterus. Diagnostic Cytopathology, 38(7), 527-32. https://doi.org/10.1002/dc.21263
Horita A, et al. Coexistent Atypical Polypoid Adenomyoma and Complex Atypical Endometrial Hyperplasia in the Uterus. Diagn Cytopathol. 2010;38(7):527-32. PubMed PMID: 19950396.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coexistent atypical polypoid adenomyoma and complex atypical endometrial hyperplasia in the uterus. AU - Horita,Ayako, AU - Kurata,Atsushi, AU - Komatsu,Kyoko, AU - Yajima,Masazumi, AU - Sakamoto,Atsuhiko, PY - 2009/12/2/entrez PY - 2009/12/2/pubmed PY - 2010/9/16/medline SP - 527 EP - 32 JF - Diagnostic cytopathology JO - Diagn Cytopathol VL - 38 IS - 7 N2 - We report a case of atypical polypoid adenomyoma (APA) concomitantly identified with complex atypical endometrial hyperplasia (CAH) in the uterus. Since an initial endometrial smear revealed atypical endometrial cells, a diagnosis of CAH was made. Even though a concomitantly performed uterine cervical smear contained both atypical epithelial and stromal cells, the diagnosis of APA was not initially made because the cytological criteria for APA had not been established. Histologically, we recognized both CAH in the uterine corpus and APA in the lower uterine segment in the hysterectomy material. Retrospectively, the cells in the first cervical smear were interpreted as part of APA because the same types of cells were observed in the intraoperative cytology sample. Although the APA and CAH lesions were interposed by normal endometrium, estrogen was suspected to be the common etiological factor. Reports regarding the cytology of APA are currently scarce. To our knowledge, this is the first report showing cytological presentation of association of APA with CAH in addition to the first cervical smear of APA containing both epithelial and stromal components. Identification of abnormal proliferation of epithelium and stromal cells of smooth muscle origin is useful in the cytological diagnosis of APA. SN - 1097-0339 UR - https://www.unboundmedicine.com/medline/citation/19950396/Coexistent_atypical_polypoid_adenomyoma_and_complex_atypical_endometrial_hyperplasia_in_the_uterus_ L2 - https://doi.org/10.1002/dc.21263 DB - PRIME DP - Unbound Medicine ER -