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Novel, tunable, and efficient chiral bisdihydrobenzooxaphosphole ligands for asymmetric hydrogenation.
Org Lett. 2010 Jan 01; 12(1):176-9.OL

Abstract

A series of novel, efficient, air-stable, and tunable chiral bisdihydrobenzooxaphosphole ligands (BIBOPs) were developed for rhodium-catalyzed hydrogenations of various functionalized olefins such as alpha-arylenamides, alpha-(acylamino)acrylic acid derivatives, beta-(acylamino)acrylates, and dimethyl itaconate with excellent enantioselectivities (up to 99% ee) and reactivities (up to 2000 TON).

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Publisher Full Text (DOI)

Authors+Show Affiliations

Tang W
Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut 06877, USA. wenjun.tang@boerhinger-ingelheim.com
Qu B
No affiliation info available
Capacci AG
No affiliation info available
Rodriguez S
No affiliation info available
Wei X
No affiliation info available
Haddad N
No affiliation info available
Narayanan B
No affiliation info available
Ma S
No affiliation info available
Grinberg N
No affiliation info available
Yee NK
No affiliation info available
Krishnamurthy D
No affiliation info available
Senanayake CH
No affiliation info available

MeSH

AcrylatesAlkenesCatalysisCombinatorial Chemistry TechniquesHydrogenationLigandsMolecular StructureOrganophosphorus CompoundsRhodiumStereoisomerism

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19950894

Citation

Tang, Wenjun, et al. "Novel, Tunable, and Efficient Chiral Bisdihydrobenzooxaphosphole Ligands for Asymmetric Hydrogenation." Organic Letters, vol. 12, no. 1, 2010, pp. 176-9.
Tang W, Qu B, Capacci AG, et al. Novel, tunable, and efficient chiral bisdihydrobenzooxaphosphole ligands for asymmetric hydrogenation. Org Lett. 2010;12(1):176-9.
Tang, W., Qu, B., Capacci, A. G., Rodriguez, S., Wei, X., Haddad, N., Narayanan, B., Ma, S., Grinberg, N., Yee, N. K., Krishnamurthy, D., & Senanayake, C. H. (2010). Novel, tunable, and efficient chiral bisdihydrobenzooxaphosphole ligands for asymmetric hydrogenation. Organic Letters, 12(1), 176-9. https://doi.org/10.1021/ol9025815
Tang W, et al. Novel, Tunable, and Efficient Chiral Bisdihydrobenzooxaphosphole Ligands for Asymmetric Hydrogenation. Org Lett. 2010 Jan 1;12(1):176-9. PubMed PMID: 19950894.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel, tunable, and efficient chiral bisdihydrobenzooxaphosphole ligands for asymmetric hydrogenation. AU - Tang,Wenjun, AU - Qu,Bo, AU - Capacci,Andrew G, AU - Rodriguez,Sonia, AU - Wei,Xudong, AU - Haddad,Nizar, AU - Narayanan,Bikashandarkoil, AU - Ma,Shengli, AU - Grinberg,Nelu, AU - Yee,Nathan K, AU - Krishnamurthy,Dhileep, AU - Senanayake,Chris H, PY - 2009/12/3/entrez PY - 2009/12/3/pubmed PY - 2010/2/24/medline SP - 176 EP - 9 JF - Organic letters JO - Org Lett VL - 12 IS - 1 N2 - A series of novel, efficient, air-stable, and tunable chiral bisdihydrobenzooxaphosphole ligands (BIBOPs) were developed for rhodium-catalyzed hydrogenations of various functionalized olefins such as alpha-arylenamides, alpha-(acylamino)acrylic acid derivatives, beta-(acylamino)acrylates, and dimethyl itaconate with excellent enantioselectivities (up to 99% ee) and reactivities (up to 2000 TON). SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/19950894/Novel_tunable_and_efficient_chiral_bisdihydrobenzooxaphosphole_ligands_for_asymmetric_hydrogenation_ L2 - https://doi.org/10.1021/ol9025815 DB - PRIME DP - Unbound Medicine ER -
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