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Assessment of serum N-terminal pro-B-type natriuretic peptide concentration for differentiation of congestive heart failure from primary respiratory tract disease as the cause of respiratory signs in dogs.
J Am Vet Med Assoc. 2009 Dec 01; 235(11):1319-25.JA

Abstract

OBJECTIVE

To determine whether serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentration is useful in discriminating between cardiac and noncardiac (ie, primary respiratory tract disease) causes of respiratory signs (ie, coughing, stertor, stridor, excessive panting, increased respiratory effort, tachypnea, or overt respiratory distress) in dogs.

DESIGN

Multicenter cross-sectional study.

ANIMALS

P 115 dogs with respiratory signs.

PROCEDURES

Dogs with respiratory signs were solicited for study. Physical examination, thoracic radiography, and echocardiography were used to determine whether respiratory signs were the result of cardiac (ie, congestive heart failure) or noncardiac (ie, primary respiratory tract disease) causes. Serum samples for NT-proBNP assay were obtained at time of admission for each dog. Receiver-operating characteristic curves were constructed to determine the ability of serum NT-proBNP concentration to discriminate between cardiac and noncardiac causes of respiratory signs.

RESULTS

Serum NT-proBNP concentration was significantly higher in dogs with cardiac versus noncardiac causes of respiratory signs. In dogs with primary respiratory tract disease, serum NT-proBNP concentration was significantly higher in those with concurrent pulmonary hypertension than in those without. A serum NT-proBNP cutoff concentration > 1,158 pmol/L discriminated between dogs with congestive heart failure and dogs with primary respiratory tract disease with a sensitivity of 85.5% and a specificity of 81.3%.

CONCLUSIONS AND CLINICAL RELEVANCE

Measuring serum NT-proBNP concentration in dogs with respiratory signs helps to differentiate between congestive heart failure and primary respiratory tract disease as an underlying cause.

Authors+Show Affiliations

Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. maoyama@vet.upenn.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19951101

Citation

Oyama, Mark A., et al. "Assessment of Serum N-terminal pro-B-type Natriuretic Peptide Concentration for Differentiation of Congestive Heart Failure From Primary Respiratory Tract Disease as the Cause of Respiratory Signs in Dogs." Journal of the American Veterinary Medical Association, vol. 235, no. 11, 2009, pp. 1319-25.
Oyama MA, Rush JE, Rozanski EA, et al. Assessment of serum N-terminal pro-B-type natriuretic peptide concentration for differentiation of congestive heart failure from primary respiratory tract disease as the cause of respiratory signs in dogs. J Am Vet Med Assoc. 2009;235(11):1319-25.
Oyama, M. A., Rush, J. E., Rozanski, E. A., Fox, P. R., Reynolds, C. A., Gordon, S. G., Bulmer, B. J., Lefbom, B. K., Brown, B. A., Lehmkuhl, L. B., Prosek, R., Lesser, M. B., Kraus, M. S., Bossbaly, M. J., Rapoport, G. S., & Boileau, J. S. (2009). Assessment of serum N-terminal pro-B-type natriuretic peptide concentration for differentiation of congestive heart failure from primary respiratory tract disease as the cause of respiratory signs in dogs. Journal of the American Veterinary Medical Association, 235(11), 1319-25. https://doi.org/10.2460/javma.235.11.1319
Oyama MA, et al. Assessment of Serum N-terminal pro-B-type Natriuretic Peptide Concentration for Differentiation of Congestive Heart Failure From Primary Respiratory Tract Disease as the Cause of Respiratory Signs in Dogs. J Am Vet Med Assoc. 2009 Dec 1;235(11):1319-25. PubMed PMID: 19951101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of serum N-terminal pro-B-type natriuretic peptide concentration for differentiation of congestive heart failure from primary respiratory tract disease as the cause of respiratory signs in dogs. AU - Oyama,Mark A, AU - Rush,John E, AU - Rozanski,Elizabeth A, AU - Fox,Philip R, AU - Reynolds,Caryn A, AU - Gordon,Sonya G, AU - Bulmer,Barret J, AU - Lefbom,Bonnie K, AU - Brown,Bill A, AU - Lehmkuhl,Linda B, AU - Prosek,Robert, AU - Lesser,Michael B, AU - Kraus,Marc S, AU - Bossbaly,Maribeth J, AU - Rapoport,Gregg S, AU - Boileau,Jean-Sebastien, PY - 2009/12/3/entrez PY - 2009/12/3/pubmed PY - 2010/1/22/medline SP - 1319 EP - 25 JF - Journal of the American Veterinary Medical Association JO - J Am Vet Med Assoc VL - 235 IS - 11 N2 - OBJECTIVE: To determine whether serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentration is useful in discriminating between cardiac and noncardiac (ie, primary respiratory tract disease) causes of respiratory signs (ie, coughing, stertor, stridor, excessive panting, increased respiratory effort, tachypnea, or overt respiratory distress) in dogs. DESIGN: Multicenter cross-sectional study. ANIMALS: P 115 dogs with respiratory signs. PROCEDURES: Dogs with respiratory signs were solicited for study. Physical examination, thoracic radiography, and echocardiography were used to determine whether respiratory signs were the result of cardiac (ie, congestive heart failure) or noncardiac (ie, primary respiratory tract disease) causes. Serum samples for NT-proBNP assay were obtained at time of admission for each dog. Receiver-operating characteristic curves were constructed to determine the ability of serum NT-proBNP concentration to discriminate between cardiac and noncardiac causes of respiratory signs. RESULTS: Serum NT-proBNP concentration was significantly higher in dogs with cardiac versus noncardiac causes of respiratory signs. In dogs with primary respiratory tract disease, serum NT-proBNP concentration was significantly higher in those with concurrent pulmonary hypertension than in those without. A serum NT-proBNP cutoff concentration > 1,158 pmol/L discriminated between dogs with congestive heart failure and dogs with primary respiratory tract disease with a sensitivity of 85.5% and a specificity of 81.3%. CONCLUSIONS AND CLINICAL RELEVANCE: Measuring serum NT-proBNP concentration in dogs with respiratory signs helps to differentiate between congestive heart failure and primary respiratory tract disease as an underlying cause. SN - 0003-1488 UR - https://www.unboundmedicine.com/medline/citation/19951101/Assessment_of_serum_N_terminal_pro_B_type_natriuretic_peptide_concentration_for_differentiation_of_congestive_heart_failure_from_primary_respiratory_tract_disease_as_the_cause_of_respiratory_signs_in_dogs_ L2 - https://avmajournals.avma.org/doi/10.2460/javma.235.11.1319?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -