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Treatment of head lice with dimeticone 4% lotion: comparison of two formulations in a randomised controlled trial in rural Turkey.
BMC Public Health. 2009 Dec 01; 9:441.BP

Abstract

BACKGROUND

Dimeticone 4% lotion was shown to be an effective treatment for head louse infestation in two randomised controlled trials in England. It is not affected by insecticide resistance but efficacy obtained (70-75%) was lower than expected. This study was designed to evaluate efficacy of dimeticone 4% lotion in a geographically, socially, and culturally different setting, in rural Turkey and, in order to achieve blinding, it was compared with a potential alternative formulation.

METHODS

Children from two village schools were screened for head lice by detection combing. All infested students and family members could participate, giving access to treatment for the whole community. Two investigator applied treatments were given 7 days apart. Outcome was assessed by detection combing three times between treatments and twice the week following second treatment.

RESULTS

In the intention to treat group 35/36 treated using dimeticone 4% had no lice after the second treatment but there were two protocol violators giving 91.7% treatment success. The alternative product gave 30/36 (83.3%) treatment success, a difference of 8.4% (95% CI -9.8% to 26.2%). The cure rates per-protocol were 33/34 (97.1%) and 30/35 (85.7%) respectively. We were unable to find any newly emerged louse nymphs on 77.8% of dimeticone 4% treated participants or on 66.7% of those treated with the alternative formulation. No adverse events were identified.

CONCLUSION

Our results confirm the efficacy of dimeticone 4% lotion against lice and eggs and we found no detectable difference between this product and dimeticone 4% lotion with nerolidol 2% added. We believe that the high cure rate was related to the lower intensity of infestation in Turkey, together with the level of community engagement, compared with previous studies in the UK.

TRIAL REGISTRATION

Current Controlled Trials ISRCTN10431107.

Authors+Show Affiliations

Celal Bayar University Medical School, Department of Parasitology, Manisa, Turkey. oz1605@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19951427

Citation

Kurt, Ozgür, et al. "Treatment of Head Lice With Dimeticone 4% Lotion: Comparison of Two Formulations in a Randomised Controlled Trial in Rural Turkey." BMC Public Health, vol. 9, 2009, p. 441.
Kurt O, Balcioğlu IC, Burgess IF, et al. Treatment of head lice with dimeticone 4% lotion: comparison of two formulations in a randomised controlled trial in rural Turkey. BMC Public Health. 2009;9:441.
Kurt, O., Balcioğlu, I. C., Burgess, I. F., Limoncu, M. E., Girginkardeşler, N., Tabak, T., Muslu, H., Ermiş, O., Sahin, M. T., Bilac, C., Kavur, H., & Ozbel, Y. (2009). Treatment of head lice with dimeticone 4% lotion: comparison of two formulations in a randomised controlled trial in rural Turkey. BMC Public Health, 9, 441. https://doi.org/10.1186/1471-2458-9-441
Kurt O, et al. Treatment of Head Lice With Dimeticone 4% Lotion: Comparison of Two Formulations in a Randomised Controlled Trial in Rural Turkey. BMC Public Health. 2009 Dec 1;9:441. PubMed PMID: 19951427.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of head lice with dimeticone 4% lotion: comparison of two formulations in a randomised controlled trial in rural Turkey. AU - Kurt,Ozgür, AU - Balcioğlu,I Cüneyt, AU - Burgess,Ian F, AU - Limoncu,M Emin, AU - Girginkardeşler,Nogay, AU - Tabak,Tuba, AU - Muslu,Hasan, AU - Ermiş,Ozge, AU - Sahin,M Turhan, AU - Bilac,Cemal, AU - Kavur,Hakan, AU - Ozbel,Yusuf, Y1 - 2009/12/01/ PY - 2009/04/24/received PY - 2009/12/01/accepted PY - 2009/12/3/entrez PY - 2009/12/3/pubmed PY - 2010/8/31/medline SP - 441 EP - 441 JF - BMC public health JO - BMC Public Health VL - 9 N2 - BACKGROUND: Dimeticone 4% lotion was shown to be an effective treatment for head louse infestation in two randomised controlled trials in England. It is not affected by insecticide resistance but efficacy obtained (70-75%) was lower than expected. This study was designed to evaluate efficacy of dimeticone 4% lotion in a geographically, socially, and culturally different setting, in rural Turkey and, in order to achieve blinding, it was compared with a potential alternative formulation. METHODS: Children from two village schools were screened for head lice by detection combing. All infested students and family members could participate, giving access to treatment for the whole community. Two investigator applied treatments were given 7 days apart. Outcome was assessed by detection combing three times between treatments and twice the week following second treatment. RESULTS: In the intention to treat group 35/36 treated using dimeticone 4% had no lice after the second treatment but there were two protocol violators giving 91.7% treatment success. The alternative product gave 30/36 (83.3%) treatment success, a difference of 8.4% (95% CI -9.8% to 26.2%). The cure rates per-protocol were 33/34 (97.1%) and 30/35 (85.7%) respectively. We were unable to find any newly emerged louse nymphs on 77.8% of dimeticone 4% treated participants or on 66.7% of those treated with the alternative formulation. No adverse events were identified. CONCLUSION: Our results confirm the efficacy of dimeticone 4% lotion against lice and eggs and we found no detectable difference between this product and dimeticone 4% lotion with nerolidol 2% added. We believe that the high cure rate was related to the lower intensity of infestation in Turkey, together with the level of community engagement, compared with previous studies in the UK. TRIAL REGISTRATION: Current Controlled Trials ISRCTN10431107. SN - 1471-2458 UR - https://www.unboundmedicine.com/medline/citation/19951427/Treatment_of_head_lice_with_dimeticone_4_lotion:_comparison_of_two_formulations_in_a_randomised_controlled_trial_in_rural_Turkey_ L2 - https://bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-9-441 DB - PRIME DP - Unbound Medicine ER -