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[Effects of glutamine-enriched enteral nutrition on nutritional status and prognosis of patients with severe head injury].
Zhonghua Shao Shang Za Zhi. 2009 Oct; 25(5):335-8.ZS

Abstract

OBJECTIVE

To investigate the effects of glutamine-enriched enteral nutrition on the nutritional status and prognosis of patients with severe head injury.

METHODS

Thirty-three patients with severe head injury were randomly divided into control group (C, 15 cases) and glutamine-enriched group (Gln, 18 cases). Patients in both groups were given routine treatment and enteral nutrition with the same amount of nitrogen and calorie. Patients in Gln group were given glutamine 0.5 g x kg(-1) x d(-1) additionally added into the nutrient fluid. Vital signs and the occurrence of side effects of all patients were observed before and after nutrition support. Venous blood and urine sample of all patients were collected before and 7, 14 days after treatment to determine the parameters of blood, urine routine and hepatorenal function. At the same time points, body mass, skin fold thickness at the region of triceps brachii (TSF), upper arm circumference (AC), upper arm muscle circumference (AMC) and fasting blood glucose of all patients were detected and determined, Glasgow coma scale (GCS) scoring was performed. The length of hospital stay of all patients was recorded.

RESULTS

Vital signs and parameters of blood, urine routine and hepatorenal function of patients in 2 groups after nutrition treatment were close to those before treatment. Side effects, such as nausea and diarrhea occurred with spontaneous remission in a few patients. There was no statistical significant difference between 2 groups, and within each group before and after treatment, in respect of body mass and TSF (P > 0.05). Values of AC and AMC of patients in Gln group were obviously higher than those of C group (P < 0.01) on post-treatment day 14. Fasting blood glucose and GCS score of all patients before treatment were close to those on post-treatment day 14 (P > 0.05). Fasting blood glucose and GCS score of patients was respectively lower and higher in Gln group than that in C group on post-treatment day 7 (P < 0.05). Length of hospital stay of patients in Gln group (25 +/- 9) d was obviously shorter than that of C group (33 +/- 12) d (P < 0.05).

CONCLUSIONS

Glutamine-enriched enteral nutrition can control the blood glucose level, prevent the loss of lean tissue, improve nutrition status of patients,shorten hospital stay, and accelerate the recovery of patients to some extent.

Authors+Show Affiliations

Nursing School of Chengdu Medical College, Chengdu 610083, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

19951555

Citation

Zeng, Jing, et al. "[Effects of Glutamine-enriched Enteral Nutrition On Nutritional Status and Prognosis of Patients With Severe Head Injury]." Zhonghua Shao Shang Za Zhi = Zhonghua Shaoshang Zazhi = Chinese Journal of Burns, vol. 25, no. 5, 2009, pp. 335-8.
Zeng J, Zhao XY, Huang Q, et al. [Effects of glutamine-enriched enteral nutrition on nutritional status and prognosis of patients with severe head injury]. Zhonghua Shao Shang Za Zhi. 2009;25(5):335-8.
Zeng, J., Zhao, X. Y., Huang, Q., & Wang, E. R. (2009). [Effects of glutamine-enriched enteral nutrition on nutritional status and prognosis of patients with severe head injury]. Zhonghua Shao Shang Za Zhi = Zhonghua Shaoshang Zazhi = Chinese Journal of Burns, 25(5), 335-8.
Zeng J, et al. [Effects of Glutamine-enriched Enteral Nutrition On Nutritional Status and Prognosis of Patients With Severe Head Injury]. Zhonghua Shao Shang Za Zhi. 2009;25(5):335-8. PubMed PMID: 19951555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of glutamine-enriched enteral nutrition on nutritional status and prognosis of patients with severe head injury]. AU - Zeng,Jing, AU - Zhao,Xiao-yu, AU - Huang,Qiong, AU - Wang,En-ren, PY - 2009/12/3/entrez PY - 2009/12/3/pubmed PY - 2010/5/7/medline SP - 335 EP - 8 JF - Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns JO - Zhonghua Shao Shang Za Zhi VL - 25 IS - 5 N2 - OBJECTIVE: To investigate the effects of glutamine-enriched enteral nutrition on the nutritional status and prognosis of patients with severe head injury. METHODS: Thirty-three patients with severe head injury were randomly divided into control group (C, 15 cases) and glutamine-enriched group (Gln, 18 cases). Patients in both groups were given routine treatment and enteral nutrition with the same amount of nitrogen and calorie. Patients in Gln group were given glutamine 0.5 g x kg(-1) x d(-1) additionally added into the nutrient fluid. Vital signs and the occurrence of side effects of all patients were observed before and after nutrition support. Venous blood and urine sample of all patients were collected before and 7, 14 days after treatment to determine the parameters of blood, urine routine and hepatorenal function. At the same time points, body mass, skin fold thickness at the region of triceps brachii (TSF), upper arm circumference (AC), upper arm muscle circumference (AMC) and fasting blood glucose of all patients were detected and determined, Glasgow coma scale (GCS) scoring was performed. The length of hospital stay of all patients was recorded. RESULTS: Vital signs and parameters of blood, urine routine and hepatorenal function of patients in 2 groups after nutrition treatment were close to those before treatment. Side effects, such as nausea and diarrhea occurred with spontaneous remission in a few patients. There was no statistical significant difference between 2 groups, and within each group before and after treatment, in respect of body mass and TSF (P > 0.05). Values of AC and AMC of patients in Gln group were obviously higher than those of C group (P < 0.01) on post-treatment day 14. Fasting blood glucose and GCS score of all patients before treatment were close to those on post-treatment day 14 (P > 0.05). Fasting blood glucose and GCS score of patients was respectively lower and higher in Gln group than that in C group on post-treatment day 7 (P < 0.05). Length of hospital stay of patients in Gln group (25 +/- 9) d was obviously shorter than that of C group (33 +/- 12) d (P < 0.05). CONCLUSIONS: Glutamine-enriched enteral nutrition can control the blood glucose level, prevent the loss of lean tissue, improve nutrition status of patients,shorten hospital stay, and accelerate the recovery of patients to some extent. SN - 1009-2587 UR - https://www.unboundmedicine.com/medline/citation/19951555/[Effects_of_glutamine_enriched_enteral_nutrition_on_nutritional_status_and_prognosis_of_patients_with_severe_head_injury]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=1009-2587&amp;year=2009&amp;vol=25&amp;issue=5&amp;fpage=335 DB - PRIME DP - Unbound Medicine ER -