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Relationship of 25-hydroxyvitamin D with all-cause and cardiovascular disease mortality in older community-dwelling adults.
Eur J Clin Nutr. 2010 Feb; 64(2):203-9.EJ

Abstract

BACKGROUND/OBJECTIVES

Vitamin D deficiency is associated with cardiovascular disease, osteoporosis, poor muscle strength, falls, fractures and mortality. Although older adults are at a higher risk of vitamin D deficiency, the relationship of serum 25-hydroxyvitamin D (25(OH)D) with all-cause and cardiovascular disease mortality has not been well characterized in the elderly. We hypothesized that low serum 25(OH)D levels predicted mortality in older adults.

SUBJECTS/METHODS

Serum 25(OH)D as well as all-cause and cardiovascular disease mortality were examined in 1006 adults, aged > or =65 years, who participated in the InCHIANTI (Invecchiare in Chianti, Aging in the Chianti Area) study, a population-based, prospective cohort study of aging in Tuscany, Italy. Serum 25(OH)D levels were measured at the time of enrollment in 1998-1999, and participants were followed up for mortality.

RESULTS

During 6.5 years of follow-up, 228 (22.7%) participants died, of whom 107 died due to cardiovascular diseases. Compared with participants in the highest quartile of serum 25(OH)D (>26.5 ng/ml) (to convert to nmol/l, multiply by 2.496), those in the lowest quartile (<10.5 ng/ml) had increased risk of all-cause mortality (Hazard Ratio (H.R.) 2.11, 95% Confidence Interval (95% C.I.): 1.22-3.64, P=0.007) and cardiovascular disease mortality (H.R. 2.64, 95% C.I.: 1.14-4.79, P=0.02), in multivariate Cox proportional hazards models that adjusted for age, sex, education, season, physical activity and other potential confounders.

CONCLUSIONS

Older community-dwelling adults with low serum 25(OH)D levels are at higher risk of all-cause and cardiovascular disease mortality.

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Authors+Show Affiliations

Semba RD
Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. rdsemba@jhmi.edu
Houston DK
No affiliation info available
Bandinelli S
No affiliation info available
Sun K
No affiliation info available
Cherubini A
No affiliation info available
Cappola AR
No affiliation info available
Guralnik JM
No affiliation info available
Ferrucci L
No affiliation info available

MeSH

AgedAged, 80 and overCardiovascular DiseasesCause of DeathFemaleHumansItalyMaleProportional Hazards ModelsProspective StudiesResidence CharacteristicsTreatment OutcomeVitamin DVitamin D Deficiency

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

19953106

Citation

Semba, R D., et al. "Relationship of 25-hydroxyvitamin D With All-cause and Cardiovascular Disease Mortality in Older Community-dwelling Adults." European Journal of Clinical Nutrition, vol. 64, no. 2, 2010, pp. 203-9.
Semba RD, Houston DK, Bandinelli S, et al. Relationship of 25-hydroxyvitamin D with all-cause and cardiovascular disease mortality in older community-dwelling adults. Eur J Clin Nutr. 2010;64(2):203-9.
Semba, R. D., Houston, D. K., Bandinelli, S., Sun, K., Cherubini, A., Cappola, A. R., Guralnik, J. M., & Ferrucci, L. (2010). Relationship of 25-hydroxyvitamin D with all-cause and cardiovascular disease mortality in older community-dwelling adults. European Journal of Clinical Nutrition, 64(2), 203-9. https://doi.org/10.1038/ejcn.2009.140
Semba RD, et al. Relationship of 25-hydroxyvitamin D With All-cause and Cardiovascular Disease Mortality in Older Community-dwelling Adults. Eur J Clin Nutr. 2010;64(2):203-9. PubMed PMID: 19953106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of 25-hydroxyvitamin D with all-cause and cardiovascular disease mortality in older community-dwelling adults. AU - Semba,R D, AU - Houston,D K, AU - Bandinelli,S, AU - Sun,K, AU - Cherubini,A, AU - Cappola,A R, AU - Guralnik,J M, AU - Ferrucci,L, Y1 - 2009/12/02/ PY - 2009/12/3/entrez PY - 2009/12/3/pubmed PY - 2010/4/15/medline SP - 203 EP - 9 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 64 IS - 2 N2 - BACKGROUND/OBJECTIVES: Vitamin D deficiency is associated with cardiovascular disease, osteoporosis, poor muscle strength, falls, fractures and mortality. Although older adults are at a higher risk of vitamin D deficiency, the relationship of serum 25-hydroxyvitamin D (25(OH)D) with all-cause and cardiovascular disease mortality has not been well characterized in the elderly. We hypothesized that low serum 25(OH)D levels predicted mortality in older adults. SUBJECTS/METHODS: Serum 25(OH)D as well as all-cause and cardiovascular disease mortality were examined in 1006 adults, aged > or =65 years, who participated in the InCHIANTI (Invecchiare in Chianti, Aging in the Chianti Area) study, a population-based, prospective cohort study of aging in Tuscany, Italy. Serum 25(OH)D levels were measured at the time of enrollment in 1998-1999, and participants were followed up for mortality. RESULTS: During 6.5 years of follow-up, 228 (22.7%) participants died, of whom 107 died due to cardiovascular diseases. Compared with participants in the highest quartile of serum 25(OH)D (>26.5 ng/ml) (to convert to nmol/l, multiply by 2.496), those in the lowest quartile (<10.5 ng/ml) had increased risk of all-cause mortality (Hazard Ratio (H.R.) 2.11, 95% Confidence Interval (95% C.I.): 1.22-3.64, P=0.007) and cardiovascular disease mortality (H.R. 2.64, 95% C.I.: 1.14-4.79, P=0.02), in multivariate Cox proportional hazards models that adjusted for age, sex, education, season, physical activity and other potential confounders. CONCLUSIONS: Older community-dwelling adults with low serum 25(OH)D levels are at higher risk of all-cause and cardiovascular disease mortality. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/19953106/Relationship_of_25_hydroxyvitamin_D_with_all_cause_and_cardiovascular_disease_mortality_in_older_community_dwelling_adults_ L2 - https://doi.org/10.1038/ejcn.2009.140 DB - PRIME DP - Unbound Medicine ER -