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[MTHFR polymorphisms, dietary folate intake and risks to breast cancer].
Zhonghua Yu Fang Yi Xue Za Zhi 2009; 43(7):576-80ZY

Abstract

OBJECTIVE

To evaluate the relationship between dietary folate intake and genetic polymorphisms of 5, 10-methylenetetrahydrofolate reductase (MTHFR) with reference to breast cancer risk.

METHODS

A case-control study was conducted with 669 cases and 682 population-based controls in Jiangsu province of China. MTHFR C677T and A1298C genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods. Dietary folate intake was assessed by using an 83-item food frequency questionnaire. Odds ratios (OR) were estimated with an unconditional logistic model.

RESULTS

The frequencies of MTHFR C677T C/C, C/T and T/T genotypes were 32.37% (202/624), 48.88% (305/624) and 18.75% (117/624) in cases and 37.66% (235/624), 48.24% (301/624) and 14. 10% (88/624) in controls, respectively. The difference in distribution was significant (chi2 = 6.616, P = 0.037), the T/T genotype being associated with an elevated OR for breast cancer (1.62, 95% CI: 1.14 -2.30). The frequencies of MTHFR A1298C A/A, A/C and C/C were 71.47% (446/624), 27.08% (169/624) and 1.44% (9/624) in cases and 68.11%(425/624), 30.13% (188/624) and 1.76% (11/624)in controls,with no significant differences found (chi2 = 1.716, P= 0.424). Folate intake of cases [(263.00 +/- 137.38) microg/d] was significantly lower than that of controls [(285.12 +/- 149.61) microg/d] (t = -2. 830, P =0.005). Compared with the lowest tertile (< or = 199.08 microg/d) of folate intake, the adjusted OR for breast cancer in the top tertile (> or = 315.11 microg/d) was 0.70 (95% CI: 0.53 -0.92). Among individuals with the MTHFR A1298C A/A genotype,adjusted OR for breast cancer were 0.89 (95% CI: 0.62 - 1.27) and 1.69 (95% CI: 1.20 - 2.36) for the second to the third tertile of folate intake compared with the highest folate intake group (X2trend = 11.372, P = 0.001).

CONCLUSION

The findings of the present study suggest that MTHFR genetic polymorphisms,and dietary intake of folate may modify susceptibility to breast cancer.

Authors+Show Affiliations

Division of Epidemiology, Jiangsu Province Institute of Cancer Research, Nanjing, China. gaocm888@126.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

19954067

Citation

Gao, Chang-Ming, et al. "[MTHFR Polymorphisms, Dietary Folate Intake and Risks to Breast Cancer]." Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine], vol. 43, no. 7, 2009, pp. 576-80.
Gao CM, Kazuo T, Tang JH, et al. [MTHFR polymorphisms, dietary folate intake and risks to breast cancer]. Zhonghua Yu Fang Yi Xue Za Zhi. 2009;43(7):576-80.
Gao, C. M., Kazuo, T., Tang, J. H., Cao, H. X., Ding, J. H., Wu, J. Z., ... Toshiro, T. (2009). [MTHFR polymorphisms, dietary folate intake and risks to breast cancer]. Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine], 43(7), pp. 576-80.
Gao CM, et al. [MTHFR Polymorphisms, Dietary Folate Intake and Risks to Breast Cancer]. Zhonghua Yu Fang Yi Xue Za Zhi. 2009;43(7):576-80. PubMed PMID: 19954067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [MTHFR polymorphisms, dietary folate intake and risks to breast cancer]. AU - Gao,Chang-Ming, AU - Kazuo,Tajima, AU - Tang,Jin-Hai, AU - Cao,Hai-Xia, AU - Ding,Jian-Hua, AU - Wu,Jian-Zhong, AU - Wang,Jie, AU - Liu,Yan-Ting, AU - Li,Su-Ping, AU - Su,Ping, AU - Keitaro,Matsuo, AU - Toshiro,Takezaki, PY - 2009/12/4/entrez PY - 2009/12/4/pubmed PY - 2010/6/11/medline SP - 576 EP - 80 JF - Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] JO - Zhonghua Yu Fang Yi Xue Za Zhi VL - 43 IS - 7 N2 - OBJECTIVE: To evaluate the relationship between dietary folate intake and genetic polymorphisms of 5, 10-methylenetetrahydrofolate reductase (MTHFR) with reference to breast cancer risk. METHODS: A case-control study was conducted with 669 cases and 682 population-based controls in Jiangsu province of China. MTHFR C677T and A1298C genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods. Dietary folate intake was assessed by using an 83-item food frequency questionnaire. Odds ratios (OR) were estimated with an unconditional logistic model. RESULTS: The frequencies of MTHFR C677T C/C, C/T and T/T genotypes were 32.37% (202/624), 48.88% (305/624) and 18.75% (117/624) in cases and 37.66% (235/624), 48.24% (301/624) and 14. 10% (88/624) in controls, respectively. The difference in distribution was significant (chi2 = 6.616, P = 0.037), the T/T genotype being associated with an elevated OR for breast cancer (1.62, 95% CI: 1.14 -2.30). The frequencies of MTHFR A1298C A/A, A/C and C/C were 71.47% (446/624), 27.08% (169/624) and 1.44% (9/624) in cases and 68.11%(425/624), 30.13% (188/624) and 1.76% (11/624)in controls,with no significant differences found (chi2 = 1.716, P= 0.424). Folate intake of cases [(263.00 +/- 137.38) microg/d] was significantly lower than that of controls [(285.12 +/- 149.61) microg/d] (t = -2. 830, P =0.005). Compared with the lowest tertile (< or = 199.08 microg/d) of folate intake, the adjusted OR for breast cancer in the top tertile (> or = 315.11 microg/d) was 0.70 (95% CI: 0.53 -0.92). Among individuals with the MTHFR A1298C A/A genotype,adjusted OR for breast cancer were 0.89 (95% CI: 0.62 - 1.27) and 1.69 (95% CI: 1.20 - 2.36) for the second to the third tertile of folate intake compared with the highest folate intake group (X2trend = 11.372, P = 0.001). CONCLUSION: The findings of the present study suggest that MTHFR genetic polymorphisms,and dietary intake of folate may modify susceptibility to breast cancer. SN - 0253-9624 UR - https://www.unboundmedicine.com/medline/citation/19954067/[MTHFR_polymorphisms_dietary_folate_intake_and_risks_to_breast_cancer]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0253-9624&amp;year=2009&amp;vol=43&amp;issue=7&amp;fpage=576 DB - PRIME DP - Unbound Medicine ER -