TY - JOUR T1 - Simultaneous HPLC analysis of pseudophedrine hydrochloride, codeine phosphate, and triprolidine hydrochloride in liquid dosage forms. AU - Manassra,Adnan, AU - Khamis,Mustafa, AU - El-Dakiky,Magdy, AU - Abdel-Qader,Zuhair, AU - Al-Rimawi,Fuad, Y1 - 2009/11/10/ PY - 2009/06/23/received PY - 2009/10/03/revised PY - 2009/10/30/accepted PY - 2009/12/4/entrez PY - 2009/12/4/pubmed PY - 2010/4/9/medline SP - 991 EP - 3 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 51 IS - 4 N2 - An HPLC method using UV detection is proposed for the simultaneous determination of pseudophedrine hydrochloride, codeine phosphate, and triprolidine hydrochloride in liquid formulation. C18 column (250mmx4.0mm) is used as the stationary phase with a mixture of methanol:acetate buffer:acetonitrile (85:5:10, v/v) as the mobile phase. The factors affecting column separation of the analytes were studied. The calibration graphs exhibited a linear concentration range of 0.06-1.0mg/ml for pseudophedrine hydrochloride, 0.02-1.0mg/ml for codeine phosphate, and 0.0025-1.0mg/ml for triprolidine hydrochloride for a sample size of 5microl with correlation coefficients of better than 0.999 for all active ingredients studied. The results demonstrate that this method is reliable, reproducible and suitable for routine use with analysis time of less than 4min. SN - 1873-264X UR - https://www.unboundmedicine.com/medline/citation/19954915/Simultaneous_HPLC_analysis_of_pseudophedrine_hydrochloride_codeine_phosphate_and_triprolidine_hydrochloride_in_liquid_dosage_forms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731-7085(09)00693-1 DB - PRIME DP - Unbound Medicine ER -