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Dietary fish oil n-3 polyunsaturated fatty acids and alpha-linolenic acid differently affect brain accretion of docosahexaenoic acid and expression of desaturases and sterol regulatory element-binding protein 1 in mice.
J Nutr Biochem 2010; 21(10):954-60JN

Abstract

Whether preformed dietary docosahexaenoic acid (DHA) is required for brain accretion has not been clearly determined. In this study, we investigated in mice the different effects of dietary longer-chain n-3 polyunsaturated fatty acids (PUFAs) and α-linolenic acid (LNA) on brain accretion of DHA and the expression of associated desaturases and transcription factors. C57 BL/6J mice were fed for 3 months with four fish oil n-3 PUFA diets--lower, low, high and higher (0.46%, 0.91%, 1.73% and 4.29% total energy, respectively); a flaxseed oil n-3 PUFA (5.01% total energy) diet; and an n-3 PUFA-deficient diet, respectively. Either fish oil or flaxseed oil n-3 PUFA diets increased DHA concentrations in the brain. However, the flaxseed oil n-3 PUFA diet was less effective than the fish oil diet with higher amount of n-3 PUFA in increasing brain DHA content. Furthermore, the expressions of delta-6 desaturase (D6D) and sterol regulatory element binding protein 1 (SREBP-1) in the liver were down-regulated by all fish oil diets with different amounts of n-3 PUFAs, as well as by the flaxseed oil n-3 PUFA diet, whereas in the brain, D6D, delta-5 desaturase (D5D) and SREBP-1 expressions were down-regulated by the higher fish oil n-3 PUFA diet rather than by other fish oil n-3 PUFA and the flaxseed oil n-3 PUFA diets. These results suggest that preformed dietary DHA, different from those converted by LNA inside the body, is better for brain accretion. Dietary longer-chain n-3 PUFAs affect expressions of D6D, D5D and SREBP-1 in the brain differently from their precursor LNA.

Authors+Show Affiliations

Clinical Nutrition Center, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19954955

Citation

Zhu, Haiyan, et al. "Dietary Fish Oil N-3 Polyunsaturated Fatty Acids and Alpha-linolenic Acid Differently Affect Brain Accretion of Docosahexaenoic Acid and Expression of Desaturases and Sterol Regulatory Element-binding Protein 1 in Mice." The Journal of Nutritional Biochemistry, vol. 21, no. 10, 2010, pp. 954-60.
Zhu H, Fan C, Xu F, et al. Dietary fish oil n-3 polyunsaturated fatty acids and alpha-linolenic acid differently affect brain accretion of docosahexaenoic acid and expression of desaturases and sterol regulatory element-binding protein 1 in mice. J Nutr Biochem. 2010;21(10):954-60.
Zhu, H., Fan, C., Xu, F., Tian, C., Zhang, F., & Qi, K. (2010). Dietary fish oil n-3 polyunsaturated fatty acids and alpha-linolenic acid differently affect brain accretion of docosahexaenoic acid and expression of desaturases and sterol regulatory element-binding protein 1 in mice. The Journal of Nutritional Biochemistry, 21(10), pp. 954-60. doi:10.1016/j.jnutbio.2009.07.011.
Zhu H, et al. Dietary Fish Oil N-3 Polyunsaturated Fatty Acids and Alpha-linolenic Acid Differently Affect Brain Accretion of Docosahexaenoic Acid and Expression of Desaturases and Sterol Regulatory Element-binding Protein 1 in Mice. J Nutr Biochem. 2010;21(10):954-60. PubMed PMID: 19954955.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fish oil n-3 polyunsaturated fatty acids and alpha-linolenic acid differently affect brain accretion of docosahexaenoic acid and expression of desaturases and sterol regulatory element-binding protein 1 in mice. AU - Zhu,Haiyan, AU - Fan,Chaonan, AU - Xu,Feng, AU - Tian,Chunyu, AU - Zhang,Feng, AU - Qi,Kemin, Y1 - 2009/12/01/ PY - 2008/09/12/received PY - 2009/04/16/revised PY - 2009/07/14/accepted PY - 2009/12/4/entrez PY - 2009/12/4/pubmed PY - 2011/2/1/medline SP - 954 EP - 60 JF - The Journal of nutritional biochemistry JO - J. Nutr. Biochem. VL - 21 IS - 10 N2 - Whether preformed dietary docosahexaenoic acid (DHA) is required for brain accretion has not been clearly determined. In this study, we investigated in mice the different effects of dietary longer-chain n-3 polyunsaturated fatty acids (PUFAs) and α-linolenic acid (LNA) on brain accretion of DHA and the expression of associated desaturases and transcription factors. C57 BL/6J mice were fed for 3 months with four fish oil n-3 PUFA diets--lower, low, high and higher (0.46%, 0.91%, 1.73% and 4.29% total energy, respectively); a flaxseed oil n-3 PUFA (5.01% total energy) diet; and an n-3 PUFA-deficient diet, respectively. Either fish oil or flaxseed oil n-3 PUFA diets increased DHA concentrations in the brain. However, the flaxseed oil n-3 PUFA diet was less effective than the fish oil diet with higher amount of n-3 PUFA in increasing brain DHA content. Furthermore, the expressions of delta-6 desaturase (D6D) and sterol regulatory element binding protein 1 (SREBP-1) in the liver were down-regulated by all fish oil diets with different amounts of n-3 PUFAs, as well as by the flaxseed oil n-3 PUFA diet, whereas in the brain, D6D, delta-5 desaturase (D5D) and SREBP-1 expressions were down-regulated by the higher fish oil n-3 PUFA diet rather than by other fish oil n-3 PUFA and the flaxseed oil n-3 PUFA diets. These results suggest that preformed dietary DHA, different from those converted by LNA inside the body, is better for brain accretion. Dietary longer-chain n-3 PUFAs affect expressions of D6D, D5D and SREBP-1 in the brain differently from their precursor LNA. SN - 1873-4847 UR - https://www.unboundmedicine.com/medline/citation/19954955/Dietary_fish_oil_n_3_polyunsaturated_fatty_acids_and_alpha_linolenic_acid_differently_affect_brain_accretion_of_docosahexaenoic_acid_and_expression_of_desaturases_and_sterol_regulatory_element_binding_protein_1_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(09)00171-5 DB - PRIME DP - Unbound Medicine ER -