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Effect of short-term creatine supplementation on markers of skeletal muscle damage after strenuous contractile activity.
Eur J Appl Physiol 2010; 108(5):945-55EJ

Abstract

The protective effect of short-term creatine supplementation (CrS) upon markers of strenuous contractile activity-induced damage in human and rat skeletal muscles was investigated. Eight Ironman triathletes were randomized into the placebo (Pl; n = 4) and creatine-supplemented (CrS; n = 4) groups. Five days prior to the Ironman competition, the CrS group received creatine monohydrate (20 g day(-1)) plus maltodextrin (50 g) divided in two equal doses. The Pl group received maltodextrin (50 g day(-1)) only. The effect of CrS (5 g day(-1)/kg body weight for 5 days) was also evaluated in a protocol of strenuous contractile activity induced by electrical stimulation in rats. Blood samples were collected before and 36 and 60 h after the competition and were used to determine plasma activities of creatine kinase (CK), lactate dehydrogenase (LDH), aldolase (ALD), glutamic oxaloacetic acid transaminase (GOT), glutamic pyruvic acid transaminase (GPT), and C-reactive protein (CRP) level. In rats, plasma activities of CK and LDH, muscle vascular permeability (MVP) using Evans blue dye, muscle force and fatigue were evaluated. Activities of CK, ALD, LDH, GOT, GTP, and levels of CRP were increased in the Pl group after the competition as compared to basal values. CrS decreased plasma activities of CK, LDH, and ALD, and prevented the rise of GOT and GPT plasma activities. In rats, CrS delayed the fatigue, preserved the force, and prevented the rise of LDH and CK plasma activities and MVP in the gastrocnemius muscle. CrS presented a protective effect on muscle injury induced by strenuous contractile activities.

Authors+Show Affiliations

Departamento de Fisiologia e Biofísica, Instituto de Ciências Biomédicas I, Universidade de São Paulo, Av. Lineu Prestes, 1524, Sala 105, Butantan, São Paulo, SP, 05508-900, Brazil. tubaraousp@sti.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19956970

Citation

Bassit, Reinaldo Abunasser, et al. "Effect of Short-term Creatine Supplementation On Markers of Skeletal Muscle Damage After Strenuous Contractile Activity." European Journal of Applied Physiology, vol. 108, no. 5, 2010, pp. 945-55.
Bassit RA, Pinheiro CH, Vitzel KF, et al. Effect of short-term creatine supplementation on markers of skeletal muscle damage after strenuous contractile activity. Eur J Appl Physiol. 2010;108(5):945-55.
Bassit, R. A., Pinheiro, C. H., Vitzel, K. F., Sproesser, A. J., Silveira, L. R., & Curi, R. (2010). Effect of short-term creatine supplementation on markers of skeletal muscle damage after strenuous contractile activity. European Journal of Applied Physiology, 108(5), pp. 945-55. doi:10.1007/s00421-009-1305-1.
Bassit RA, et al. Effect of Short-term Creatine Supplementation On Markers of Skeletal Muscle Damage After Strenuous Contractile Activity. Eur J Appl Physiol. 2010;108(5):945-55. PubMed PMID: 19956970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of short-term creatine supplementation on markers of skeletal muscle damage after strenuous contractile activity. AU - Bassit,Reinaldo Abunasser, AU - Pinheiro,Carlos Hermano da Justa, AU - Vitzel,Kaio Fernando, AU - Sproesser,Antônio José, AU - Silveira,Leonardo R, AU - Curi,Rui, Y1 - 2009/12/03/ PY - 2009/11/16/accepted PY - 2009/12/4/entrez PY - 2009/12/4/pubmed PY - 2010/6/2/medline SP - 945 EP - 55 JF - European journal of applied physiology JO - Eur. J. Appl. Physiol. VL - 108 IS - 5 N2 - The protective effect of short-term creatine supplementation (CrS) upon markers of strenuous contractile activity-induced damage in human and rat skeletal muscles was investigated. Eight Ironman triathletes were randomized into the placebo (Pl; n = 4) and creatine-supplemented (CrS; n = 4) groups. Five days prior to the Ironman competition, the CrS group received creatine monohydrate (20 g day(-1)) plus maltodextrin (50 g) divided in two equal doses. The Pl group received maltodextrin (50 g day(-1)) only. The effect of CrS (5 g day(-1)/kg body weight for 5 days) was also evaluated in a protocol of strenuous contractile activity induced by electrical stimulation in rats. Blood samples were collected before and 36 and 60 h after the competition and were used to determine plasma activities of creatine kinase (CK), lactate dehydrogenase (LDH), aldolase (ALD), glutamic oxaloacetic acid transaminase (GOT), glutamic pyruvic acid transaminase (GPT), and C-reactive protein (CRP) level. In rats, plasma activities of CK and LDH, muscle vascular permeability (MVP) using Evans blue dye, muscle force and fatigue were evaluated. Activities of CK, ALD, LDH, GOT, GTP, and levels of CRP were increased in the Pl group after the competition as compared to basal values. CrS decreased plasma activities of CK, LDH, and ALD, and prevented the rise of GOT and GPT plasma activities. In rats, CrS delayed the fatigue, preserved the force, and prevented the rise of LDH and CK plasma activities and MVP in the gastrocnemius muscle. CrS presented a protective effect on muscle injury induced by strenuous contractile activities. SN - 1439-6327 UR - https://www.unboundmedicine.com/medline/citation/19956970/Effect_of_short_term_creatine_supplementation_on_markers_of_skeletal_muscle_damage_after_strenuous_contractile_activity_ L2 - https://dx.doi.org/10.1007/s00421-009-1305-1 DB - PRIME DP - Unbound Medicine ER -