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[The prevalence of hepatitis C virus (HCV) subtypes in Chinese HIV-1/HCV co-infected individuals].
Zhonghua Liu Xing Bing Xue Za Zhi. 2009 Jul; 30(7):663-7.ZL

Abstract

OBJECTIVE

To better understand the prevalence and geographic distribution of genotypes/subtypes on HCV and the relationship between HCV genotypes/subtypes and HIV infection disease progression in the HIV-1/HCV co-infected individuals living in high HIV-1 prevalent areas in China.

METHODS

186 plasma samples were collected from HIV-1 seropositive individuals infected through paid blood donors (PBD), injecting drug users(IDUs) or sexual contact, living in most severely affected provinces, Henan, Yunnan, Xinjiang, Jilin and Liaoning provinces. Samples with HCV viral load >1000 cop/ml were amplified by RT-nested PCR, sequenced and phylogenetically analyzed for genotyping/subtyping of HCV. HIV-1, HCV viral loads and CD4+ T lymphocytes were measured for all subjects.

RESULTS

(1) HCV were identified as 1a (1.7%), 1b (39.9%), 2a (17.9%), 3a (10.4%), 3b (15.6%), 6a (1.2%), 6n (6.4%), and a newly unclassified subtype (7.5%). HCV 2a and 1b subtypes predominated in PBD in Henan, 3a and 3b in IDUs in Xinjiang and Yunnan, and 6 genotype/subtypes in IDU in Yunnan. (2) There were no significant differences in CD4+ T cell counts among the different HCV subtypes. (3) The viral load of HCV RNA in 1b subtype was higher than that of non-1b subtype, however, no significant differences in HIV-1 viral loads and CD4+ T cell counts were found between 1b and non-lb subtype. Both HIV and HCV viral loads were lower in 2a than non-2a subtype.

CONCLUSION

The prevalence of HCV genotype/subtype in HIV-1/HCV co-infected individuals was associated with geographic areas and transmission routes. HCV subtypes had no direct correlation with HIV infection disease progression.

Authors+Show Affiliations

The Key Laboratory of AIDS Immunology of the Ministry of Health, the First Hospital, China Medical University, Shenyang, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

19957585

Citation

Liu, Jing, et al. "[The Prevalence of Hepatitis C Virus (HCV) Subtypes in Chinese HIV-1/HCV Co-infected Individuals]." Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, vol. 30, no. 7, 2009, pp. 663-7.
Liu J, Yang Y, Gong JL, et al. [The prevalence of hepatitis C virus (HCV) subtypes in Chinese HIV-1/HCV co-infected individuals]. Zhonghua Liu Xing Bing Xue Za Zhi. 2009;30(7):663-7.
Liu, J., Yang, Y., Gong, J. L., Zhang, Z. N., Zhang, M., Wang, Y. N., Jiang, Y. J., Qi, Z. T., Pan, Q. C., Zhong, P., & Shang, H. (2009). [The prevalence of hepatitis C virus (HCV) subtypes in Chinese HIV-1/HCV co-infected individuals]. Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, 30(7), 663-7.
Liu J, et al. [The Prevalence of Hepatitis C Virus (HCV) Subtypes in Chinese HIV-1/HCV Co-infected Individuals]. Zhonghua Liu Xing Bing Xue Za Zhi. 2009;30(7):663-7. PubMed PMID: 19957585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The prevalence of hepatitis C virus (HCV) subtypes in Chinese HIV-1/HCV co-infected individuals]. AU - Liu,Jing, AU - Yang,Yang, AU - Gong,Ju-Li, AU - Zhang,Zi-Ning, AU - Zhang,Min, AU - Wang,Ya-Nan, AU - Jiang,Yong-Jun, AU - Qi,Zhong-Tian, AU - Pan,Qi-Chao, AU - Zhong,Ping, AU - Shang,Hong, PY - 2009/12/5/entrez PY - 2009/12/5/pubmed PY - 2010/5/21/medline SP - 663 EP - 7 JF - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi JO - Zhonghua Liu Xing Bing Xue Za Zhi VL - 30 IS - 7 N2 - OBJECTIVE: To better understand the prevalence and geographic distribution of genotypes/subtypes on HCV and the relationship between HCV genotypes/subtypes and HIV infection disease progression in the HIV-1/HCV co-infected individuals living in high HIV-1 prevalent areas in China. METHODS: 186 plasma samples were collected from HIV-1 seropositive individuals infected through paid blood donors (PBD), injecting drug users(IDUs) or sexual contact, living in most severely affected provinces, Henan, Yunnan, Xinjiang, Jilin and Liaoning provinces. Samples with HCV viral load >1000 cop/ml were amplified by RT-nested PCR, sequenced and phylogenetically analyzed for genotyping/subtyping of HCV. HIV-1, HCV viral loads and CD4+ T lymphocytes were measured for all subjects. RESULTS: (1) HCV were identified as 1a (1.7%), 1b (39.9%), 2a (17.9%), 3a (10.4%), 3b (15.6%), 6a (1.2%), 6n (6.4%), and a newly unclassified subtype (7.5%). HCV 2a and 1b subtypes predominated in PBD in Henan, 3a and 3b in IDUs in Xinjiang and Yunnan, and 6 genotype/subtypes in IDU in Yunnan. (2) There were no significant differences in CD4+ T cell counts among the different HCV subtypes. (3) The viral load of HCV RNA in 1b subtype was higher than that of non-1b subtype, however, no significant differences in HIV-1 viral loads and CD4+ T cell counts were found between 1b and non-lb subtype. Both HIV and HCV viral loads were lower in 2a than non-2a subtype. CONCLUSION: The prevalence of HCV genotype/subtype in HIV-1/HCV co-infected individuals was associated with geographic areas and transmission routes. HCV subtypes had no direct correlation with HIV infection disease progression. SN - 0254-6450 UR - https://www.unboundmedicine.com/medline/citation/19957585/[The_prevalence_of_hepatitis_C_virus__HCV__subtypes_in_Chinese_HIV_1/HCV_co_infected_individuals]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0254-6450&year=2009&vol=30&issue=7&fpage=663 DB - PRIME DP - Unbound Medicine ER -