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[Evaluation of RCAS1 as serum tumor marker for pancreatic cancer].
Zhonghua Wai Ke Za Zhi. 2009 Jul 01; 47(13):999-1001.ZW

Abstract

OBJECTIVE

To evaluate the effect of receptor-binding cancer antigen expressed on SiSO cells (RCAS1) as serum tumor marker on the diagnosis of pancreatic cancer.

METHODS

Receiver-operating characteristics (ROC) curve methods were used to assay the serum content of RCAS1, CA19-9 and CA242 in 46 patients with pancreatic cancer, 18 patients and 20 normal tissues of chronic pancreatitis detected by enzyme linked immunosorbent assay (ELISA), and the results were analyzed by statistics methods. The expressions of RCAS1 protein were analyzed by immunohistochemical method in 32 patients with pancreatic cancer, 10 patients with chronic pancreatitis and 6 cases of normal pancreatic specimens.

RESULTS

The serum levels of RCAS1, CA19-9 and CA242 in pancreatic cancer were higher than that in chronic pancreatitis respectively (P < 0.01). The area under curve of RCAS1, CA19-9 and CA242 were 0.826, 0.804 and 0.737, respectively. Subgroup analysis indicated that the RCAS1 and CA19-9 levels of pancreatic cancer patients without obstructive jaundice were lower than those for patients with obstructive jaundice (P < 0.01). CA19-9 levels of patients with resectable pancreatic cancer were lower than those with unresectable pancreatic cancer (P < 0.01). Immunohistochemistry showed that the expression rates of RCAS1 in pancreatic cancer and chronic pancreatitis were 87.5% and 40.0%, respectively (P < 0.05).

CONCLUSIONS

In diagnosis of pancreatic cancer, the clinical value of RCAS1 is available. And the combination test of RCAS1 and CA19-9 have clinical value to evaluate if the pancreatic cancer can be resected before operation.

Authors+Show Affiliations

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing 100730, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

19957811

Citation

Yang, Ying-chi, et al. "[Evaluation of RCAS1 as Serum Tumor Marker for Pancreatic Cancer]." Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery], vol. 47, no. 13, 2009, pp. 999-1001.
Yang YC, Zhao YP, Liao Q, et al. [Evaluation of RCAS1 as serum tumor marker for pancreatic cancer]. Zhonghua Wai Ke Za Zhi. 2009;47(13):999-1001.
Yang, Y. C., Zhao, Y. P., Liao, Q., Zhang, T. P., Hu, Y., & Dai, M. H. (2009). [Evaluation of RCAS1 as serum tumor marker for pancreatic cancer]. Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery], 47(13), 999-1001.
Yang YC, et al. [Evaluation of RCAS1 as Serum Tumor Marker for Pancreatic Cancer]. Zhonghua Wai Ke Za Zhi. 2009 Jul 1;47(13):999-1001. PubMed PMID: 19957811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Evaluation of RCAS1 as serum tumor marker for pancreatic cancer]. AU - Yang,Ying-chi, AU - Zhao,Yu-pei, AU - Liao,Quan, AU - Zhang,Tai-ping, AU - Hu,Ya, AU - Dai,Meng-hua, PY - 2009/12/5/entrez PY - 2009/12/5/pubmed PY - 2010/9/3/medline SP - 999 EP - 1001 JF - Zhonghua wai ke za zhi [Chinese journal of surgery] JO - Zhonghua Wai Ke Za Zhi VL - 47 IS - 13 N2 - OBJECTIVE: To evaluate the effect of receptor-binding cancer antigen expressed on SiSO cells (RCAS1) as serum tumor marker on the diagnosis of pancreatic cancer. METHODS: Receiver-operating characteristics (ROC) curve methods were used to assay the serum content of RCAS1, CA19-9 and CA242 in 46 patients with pancreatic cancer, 18 patients and 20 normal tissues of chronic pancreatitis detected by enzyme linked immunosorbent assay (ELISA), and the results were analyzed by statistics methods. The expressions of RCAS1 protein were analyzed by immunohistochemical method in 32 patients with pancreatic cancer, 10 patients with chronic pancreatitis and 6 cases of normal pancreatic specimens. RESULTS: The serum levels of RCAS1, CA19-9 and CA242 in pancreatic cancer were higher than that in chronic pancreatitis respectively (P < 0.01). The area under curve of RCAS1, CA19-9 and CA242 were 0.826, 0.804 and 0.737, respectively. Subgroup analysis indicated that the RCAS1 and CA19-9 levels of pancreatic cancer patients without obstructive jaundice were lower than those for patients with obstructive jaundice (P < 0.01). CA19-9 levels of patients with resectable pancreatic cancer were lower than those with unresectable pancreatic cancer (P < 0.01). Immunohistochemistry showed that the expression rates of RCAS1 in pancreatic cancer and chronic pancreatitis were 87.5% and 40.0%, respectively (P < 0.05). CONCLUSIONS: In diagnosis of pancreatic cancer, the clinical value of RCAS1 is available. And the combination test of RCAS1 and CA19-9 have clinical value to evaluate if the pancreatic cancer can be resected before operation. SN - 0529-5815 UR - https://www.unboundmedicine.com/medline/citation/19957811/[Evaluation_of_RCAS1_as_serum_tumor_marker_for_pancreatic_cancer]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0529-5815&amp;year=2009&amp;vol=47&amp;issue=13&amp;fpage=999 DB - PRIME DP - Unbound Medicine ER -