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Protective role of sertraline against 3-nitropropionic acid-induced cognitive dysfunction and redox ratio in striatum, cortex and hippocampus of rat brain.
Indian J Exp Biol. 2009 Sep; 47(9):715-22.IJ

Abstract

Huntington's disease (HD) is an inherited progressive neurodegenerative disorder in human characterized by progressive loss of movement and cognitive disturbances. 3-nitropropionic acid (3-NP; a mitochondrial toxin) produces age-dependent oxidative linked striatal damage, responsible for HD like symptoms. In the present study protective effect of sertraline in 3-NP induced HD like symptoms was evaluated in rats. Systemic administration of 3-NP (10 mg/kg for 14 days) resulted in impairment of memory as assessed in Morris water maze and elevated plus paradigm tasks. Biochemical analysis revealed that systemic 3-NP administration significantly impaired reduced glutathione, total glutathione, oxidized glutathione and glutathione-S-transferase levels, whereas the level of acetylcholinesterase enzyme increased in striatum, cortex and hippocampus regions of rat brain. Sertraline (5 and 10 mg/kg po) treatment once daily for 14 days significantly improved cognitive performance tasks and glutathione levels in 3-NP treated group. However, combination of yohimbine (2 mg/kg) (non selective serotonin receptors antagonist) with the higher dose of sertraline (10 mg/kg) did not influence the protective action of sertraline. Result shows that neuroprotective and antioxidant like effect of sertraline is independent of its conventional action on 5-HT receptor.

Authors+Show Affiliations

Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19957883

Citation

Kumar, Puneet, and Anil Kumar. "Protective Role of Sertraline Against 3-nitropropionic Acid-induced Cognitive Dysfunction and Redox Ratio in Striatum, Cortex and Hippocampus of Rat Brain." Indian Journal of Experimental Biology, vol. 47, no. 9, 2009, pp. 715-22.
Kumar P, Kumar A. Protective role of sertraline against 3-nitropropionic acid-induced cognitive dysfunction and redox ratio in striatum, cortex and hippocampus of rat brain. Indian J Exp Biol. 2009;47(9):715-22.
Kumar, P., & Kumar, A. (2009). Protective role of sertraline against 3-nitropropionic acid-induced cognitive dysfunction and redox ratio in striatum, cortex and hippocampus of rat brain. Indian Journal of Experimental Biology, 47(9), 715-22.
Kumar P, Kumar A. Protective Role of Sertraline Against 3-nitropropionic Acid-induced Cognitive Dysfunction and Redox Ratio in Striatum, Cortex and Hippocampus of Rat Brain. Indian J Exp Biol. 2009;47(9):715-22. PubMed PMID: 19957883.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective role of sertraline against 3-nitropropionic acid-induced cognitive dysfunction and redox ratio in striatum, cortex and hippocampus of rat brain. AU - Kumar,Puneet, AU - Kumar,Anil, PY - 2009/12/5/entrez PY - 2009/12/5/pubmed PY - 2009/12/23/medline SP - 715 EP - 22 JF - Indian journal of experimental biology JO - Indian J Exp Biol VL - 47 IS - 9 N2 - Huntington's disease (HD) is an inherited progressive neurodegenerative disorder in human characterized by progressive loss of movement and cognitive disturbances. 3-nitropropionic acid (3-NP; a mitochondrial toxin) produces age-dependent oxidative linked striatal damage, responsible for HD like symptoms. In the present study protective effect of sertraline in 3-NP induced HD like symptoms was evaluated in rats. Systemic administration of 3-NP (10 mg/kg for 14 days) resulted in impairment of memory as assessed in Morris water maze and elevated plus paradigm tasks. Biochemical analysis revealed that systemic 3-NP administration significantly impaired reduced glutathione, total glutathione, oxidized glutathione and glutathione-S-transferase levels, whereas the level of acetylcholinesterase enzyme increased in striatum, cortex and hippocampus regions of rat brain. Sertraline (5 and 10 mg/kg po) treatment once daily for 14 days significantly improved cognitive performance tasks and glutathione levels in 3-NP treated group. However, combination of yohimbine (2 mg/kg) (non selective serotonin receptors antagonist) with the higher dose of sertraline (10 mg/kg) did not influence the protective action of sertraline. Result shows that neuroprotective and antioxidant like effect of sertraline is independent of its conventional action on 5-HT receptor. SN - 0019-5189 UR - https://www.unboundmedicine.com/medline/citation/19957883/Protective_role_of_sertraline_against_3_nitropropionic_acid_induced_cognitive_dysfunction_and_redox_ratio_in_striatum_cortex_and_hippocampus_of_rat_brain_ DB - PRIME DP - Unbound Medicine ER -