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Synthesis of core-shell surface-enhanced Raman tags for bioimaging.
Anal Chem. 2010 Jan 01; 82(1):441-6.AC

Abstract

We present a rapid and straightforward procedure for the synthesis of core-shell surface-enhanced Raman scattering (SERS) tags. SERS tags are combinations of Raman active dyes with metallic nanoparticles inducing the enhancement. Because of their significantly higher stability to environmental conditions, the majority of SERS tags are designed in core-shell geometry. The main disadvantage of this approach up to now was the time-consuming (normally days) and complex preparation of these labeled core-shell particles. The presented approach can be performed within hours on a daily base. The main characteristics and the stability of the fabricated SERS tags in extreme pH values, high ion strength, or in organic solvent is demonstrated in this communication. Furthermore, the SERS tags are functionalized with anti-Salmonella antibody as a model to present a potential application of the core-shell particles in bioimaging.

Authors+Show Affiliations

Chair for Analytical Chemistry, Technische Universität München, Marchioninistrasse 17, D 81377 Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19957963

Citation

Liu, Xiangjiang, et al. "Synthesis of Core-shell Surface-enhanced Raman Tags for Bioimaging." Analytical Chemistry, vol. 82, no. 1, 2010, pp. 441-6.
Liu X, Knauer M, Ivleva NP, et al. Synthesis of core-shell surface-enhanced Raman tags for bioimaging. Anal Chem. 2010;82(1):441-6.
Liu, X., Knauer, M., Ivleva, N. P., Niessner, R., & Haisch, C. (2010). Synthesis of core-shell surface-enhanced Raman tags for bioimaging. Analytical Chemistry, 82(1), 441-6. https://doi.org/10.1021/ac902573p
Liu X, et al. Synthesis of Core-shell Surface-enhanced Raman Tags for Bioimaging. Anal Chem. 2010 Jan 1;82(1):441-6. PubMed PMID: 19957963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis of core-shell surface-enhanced Raman tags for bioimaging. AU - Liu,Xiangjiang, AU - Knauer,Maria, AU - Ivleva,Natalia P, AU - Niessner,Reinhard, AU - Haisch,Christoph, PY - 2009/12/5/entrez PY - 2009/12/5/pubmed PY - 2010/3/23/medline SP - 441 EP - 6 JF - Analytical chemistry JO - Anal Chem VL - 82 IS - 1 N2 - We present a rapid and straightforward procedure for the synthesis of core-shell surface-enhanced Raman scattering (SERS) tags. SERS tags are combinations of Raman active dyes with metallic nanoparticles inducing the enhancement. Because of their significantly higher stability to environmental conditions, the majority of SERS tags are designed in core-shell geometry. The main disadvantage of this approach up to now was the time-consuming (normally days) and complex preparation of these labeled core-shell particles. The presented approach can be performed within hours on a daily base. The main characteristics and the stability of the fabricated SERS tags in extreme pH values, high ion strength, or in organic solvent is demonstrated in this communication. Furthermore, the SERS tags are functionalized with anti-Salmonella antibody as a model to present a potential application of the core-shell particles in bioimaging. SN - 1520-6882 UR - https://www.unboundmedicine.com/medline/citation/19957963/Synthesis_of_core_shell_surface_enhanced_Raman_tags_for_bioimaging_ L2 - https://doi.org/10.1021/ac902573p DB - PRIME DP - Unbound Medicine ER -