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[Clinical and histological features of non-alcoholic fatty liver disease].
Zhonghua Gan Zang Bing Za Zhi. 2009 Nov; 17(11):812-6.ZG

Abstract

OBJECTIVE

To investigate the clinical and histological features in Chinese patients with non-alcoholic fatty liver disease (NAFLD).

METHODS

108 patients with biopsy-proven NAFLD were enrolled in this study. Clinical, demographic, and biochemical data were compared between NAFLD patients with abnormal ALT and those with normal ALT.

RESULTS

Simple fatty liver, nonalcoholic steatohepatitis(NASH) and cirrhosis were diagnosed in 49 (45.4%), 57(52.7%) and 2 (1.9%) patients, respectively. ALT and AST levels of NASH group were higher than those of simple fatty liver group (t = 2.55, 3.13; P = 0.01, 0.00). Fifty of the 77 patients (64.9%) with abnormal ALT levels were diagnosed as non-alcoholic steatohepatitis (NASH), and twenty-six were diagnosed as simple fatty liver, according to liver histology. Among the 31 patients with normal ALT levels, nine (29%) had NASH and twenty-two had simple fatty liver (P = 0.00). The patients with normal ALT had lower necroinflammatory grade than patients with abnormal ALT (x2 = 10.30, P = 0.01), but they had similar degree of steatosis and fibrosis (x2 = 5.52, 6.12; P = 0.12, 0.01). AST, g-glutamyltransferase, total cholesterol, apolipoprotein A1, apolipoprotein B and systolic blood pressure of patients with normal ALT were all lower than those of patients with abnormal ALT (t = 5.91, 2.00, 2.30, 2.10, 3.14, 2.43; P = 0.00, 0.05, 0.02, 0.04, 0.00, 0.02), while spleen thickness and AST/ALT ratio in patients with normal ALT were higher than those with abnormal ALT significantly (t = 3.70, 2.95; P = 0.00, 0.01). Multivariate analysis revealed that ALT (OR = 2.78, 95% CI 1.06-7.3, P = 0.04) was the only independent predictor of NASH, and ALT had low accuracy in predicting NASH, the area under the receiver operating characteristics curves of ALT to predict NASH was 0.69 (95% CI 0.59-0.8, P = 0.00).

CONCLUSION

NAFLD patients have higher ALT level, and elevated serum level of ALT is independent predictor of the degree of inflammation, but not of steatosis and fibrosis.

Authors+Show Affiliations

Hangzhou Sixth Hospital, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310014, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

19958638

Citation

Shi, Jun-ping, et al. "[Clinical and Histological Features of Non-alcoholic Fatty Liver Disease]." Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology, vol. 17, no. 11, 2009, pp. 812-6.
Shi JP, Xun YH, Hu CB, et al. [Clinical and histological features of non-alcoholic fatty liver disease]. Zhonghua Gan Zang Bing Za Zhi. 2009;17(11):812-6.
Shi, J. P., Xun, Y. H., Hu, C. B., Zhang, L., Liu, H., Lou, G. Q., & Fan, J. G. (2009). [Clinical and histological features of non-alcoholic fatty liver disease]. Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology, 17(11), 812-6.
Shi JP, et al. [Clinical and Histological Features of Non-alcoholic Fatty Liver Disease]. Zhonghua Gan Zang Bing Za Zhi. 2009;17(11):812-6. PubMed PMID: 19958638.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical and histological features of non-alcoholic fatty liver disease]. AU - Shi,Jun-ping, AU - Xun,Yun-hao, AU - Hu,Chen-bo, AU - Zhang,Li, AU - Liu,Hong, AU - Lou,Guo-qiang, AU - Fan,Jian-gao, PY - 2009/12/5/entrez PY - 2009/12/5/pubmed PY - 2010/9/3/medline SP - 812 EP - 6 JF - Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology JO - Zhonghua Gan Zang Bing Za Zhi VL - 17 IS - 11 N2 - OBJECTIVE: To investigate the clinical and histological features in Chinese patients with non-alcoholic fatty liver disease (NAFLD). METHODS: 108 patients with biopsy-proven NAFLD were enrolled in this study. Clinical, demographic, and biochemical data were compared between NAFLD patients with abnormal ALT and those with normal ALT. RESULTS: Simple fatty liver, nonalcoholic steatohepatitis(NASH) and cirrhosis were diagnosed in 49 (45.4%), 57(52.7%) and 2 (1.9%) patients, respectively. ALT and AST levels of NASH group were higher than those of simple fatty liver group (t = 2.55, 3.13; P = 0.01, 0.00). Fifty of the 77 patients (64.9%) with abnormal ALT levels were diagnosed as non-alcoholic steatohepatitis (NASH), and twenty-six were diagnosed as simple fatty liver, according to liver histology. Among the 31 patients with normal ALT levels, nine (29%) had NASH and twenty-two had simple fatty liver (P = 0.00). The patients with normal ALT had lower necroinflammatory grade than patients with abnormal ALT (x2 = 10.30, P = 0.01), but they had similar degree of steatosis and fibrosis (x2 = 5.52, 6.12; P = 0.12, 0.01). AST, g-glutamyltransferase, total cholesterol, apolipoprotein A1, apolipoprotein B and systolic blood pressure of patients with normal ALT were all lower than those of patients with abnormal ALT (t = 5.91, 2.00, 2.30, 2.10, 3.14, 2.43; P = 0.00, 0.05, 0.02, 0.04, 0.00, 0.02), while spleen thickness and AST/ALT ratio in patients with normal ALT were higher than those with abnormal ALT significantly (t = 3.70, 2.95; P = 0.00, 0.01). Multivariate analysis revealed that ALT (OR = 2.78, 95% CI 1.06-7.3, P = 0.04) was the only independent predictor of NASH, and ALT had low accuracy in predicting NASH, the area under the receiver operating characteristics curves of ALT to predict NASH was 0.69 (95% CI 0.59-0.8, P = 0.00). CONCLUSION: NAFLD patients have higher ALT level, and elevated serum level of ALT is independent predictor of the degree of inflammation, but not of steatosis and fibrosis. SN - 1007-3418 UR - https://www.unboundmedicine.com/medline/citation/19958638/[Clinical_and_histological_features_of_non_alcoholic_fatty_liver_disease]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=1007-3418&year=2009&vol=17&issue=11&fpage=812 DB - PRIME DP - Unbound Medicine ER -