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Rouleaux formation in sickle cell traits.
J Trop Med Hyg. 1991 Feb; 94(1):42-4.JT

Abstract

Rouleaux formation of washed red blood cells (r.b.c.s) from subjects with sickle cell trait (HbAS) was measured by the rapid coagulation method. The r.b.c.s were suspended in the donor's native plasma or in 1.3% dextran in phosphate-buffered Ringer solution at pHs of 6.5, 7.4 and 8.2. HbAS cells showed more rouleaux formation than HbAA (normal) cells in plasma (P less than 0.005). Plasma fibrinogen concentration of HbAS and HbAA subjects did not differ significantly (mean 2.9, s.d. 0.7 g l-1 for both groups). In the dextran solution, HbAS cells were more aggregable at pH 6.5 but less at pH 8.2 than HbAA cells. There was no significant difference in dextran-induced aggregation between the two groups of cells at pH 7.4. The results suggest that HbAS subjects may be more prone to intravascular sludging and stasis and that this risk may be enhanced by reduction in pH of blood.

Authors+Show Affiliations

Department of Physiology, College of Medical Sciences, University of Calabar, Nigeria.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

1995933

Citation

Obiefuna, P C.. "Rouleaux Formation in Sickle Cell Traits." The Journal of Tropical Medicine and Hygiene, vol. 94, no. 1, 1991, pp. 42-4.
Obiefuna PC. Rouleaux formation in sickle cell traits. J Trop Med Hyg. 1991;94(1):42-4.
Obiefuna, P. C. (1991). Rouleaux formation in sickle cell traits. The Journal of Tropical Medicine and Hygiene, 94(1), 42-4.
Obiefuna PC. Rouleaux Formation in Sickle Cell Traits. J Trop Med Hyg. 1991;94(1):42-4. PubMed PMID: 1995933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rouleaux formation in sickle cell traits. A1 - Obiefuna,P C, PY - 1991/2/1/pubmed PY - 1991/2/1/medline PY - 1991/2/1/entrez SP - 42 EP - 4 JF - The Journal of tropical medicine and hygiene JO - J Trop Med Hyg VL - 94 IS - 1 N2 - Rouleaux formation of washed red blood cells (r.b.c.s) from subjects with sickle cell trait (HbAS) was measured by the rapid coagulation method. The r.b.c.s were suspended in the donor's native plasma or in 1.3% dextran in phosphate-buffered Ringer solution at pHs of 6.5, 7.4 and 8.2. HbAS cells showed more rouleaux formation than HbAA (normal) cells in plasma (P less than 0.005). Plasma fibrinogen concentration of HbAS and HbAA subjects did not differ significantly (mean 2.9, s.d. 0.7 g l-1 for both groups). In the dextran solution, HbAS cells were more aggregable at pH 6.5 but less at pH 8.2 than HbAA cells. There was no significant difference in dextran-induced aggregation between the two groups of cells at pH 7.4. The results suggest that HbAS subjects may be more prone to intravascular sludging and stasis and that this risk may be enhanced by reduction in pH of blood. SN - 0022-5304 UR - https://www.unboundmedicine.com/medline/citation/1995933/Rouleaux_formation_in_sickle_cell_traits_ DB - PRIME DP - Unbound Medicine ER -