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Association between serum uric acid and non-alcoholic fatty liver disease in Korean adults.
Clin Chem Lab Med. 2010 Feb; 48(2):175-80.CC

Abstract

BACKGROUND

Increased uric acid is associated with the metabolic syndrome, conditions linked to oxidative stress and insulin resistance. Non-alcoholic fatty liver disease (NAFLD) is now considered a hepatic manifestation of insulin resistance. However, little has been written regarding the association between uric acid and NAFLD.

METHODS

We examined the association between uric acid and the presence of NAFLD in 3768 Koreans (2133 men, 1635 women; aged 20-75 years) in a health examination program. Uric acid quartiles were categorized separately as follows: Q1: <or=291.5, Q2: 291.6-333.1, Q3: 333.2-380.7, and Q4: >or=380.8 micromol/L for men; Q1: <or=202.2, Q2: 202.3-232.0, Q3: 231.1-267.7, and Q4: >or=267.8 micromol/L for women. Hepatic steatosis was diagnosed based on abdominal ultrasonographic findings by hyperechogenicity of liver tissue, difference of echogenicity between the liver and diaphragm, and visibility of vascular structures. The odds ratios (ORs) and 95% confidence intervals (CIs) for NAFLD were calculated across each quartile of serum uric acid.

RESULTS

The prevalence of NAFLD was 25.8% (32.2% in men and 17.4% in women). After adjustment for age, body mass index (BMI), smoking, regular exercise, blood pressure, fasting plasma glucose (FPG), triglycerides, and high-density lipoprotein (HDL) cholesterol, the ORs (95% CIs) for NAFLD according to each quartile of uric acid were 1.00, 1.55 (1.13-2.14), 1.77 (1.30-2.41), and 2.01 (1.45-2.78) for men and 1.00, 0.69 (0.40-1.20), 1.12 (0.67-1.88), and 1.94 (1.21-3.13) for women.

CONCLUSIONS

Serum uric acid is independently associated with the presence of NAFLD, and uric acid may be a useful additional measure in assessing the risk of NAFLD in the clinical setting.

Authors+Show Affiliations

Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19961393

Citation

Lee, Yong-Jae, et al. "Association Between Serum Uric Acid and Non-alcoholic Fatty Liver Disease in Korean Adults." Clinical Chemistry and Laboratory Medicine, vol. 48, no. 2, 2010, pp. 175-80.
Lee YJ, Lee HR, Lee JH, et al. Association between serum uric acid and non-alcoholic fatty liver disease in Korean adults. Clin Chem Lab Med. 2010;48(2):175-80.
Lee, Y. J., Lee, H. R., Lee, J. H., Shin, Y. H., & Shim, J. Y. (2010). Association between serum uric acid and non-alcoholic fatty liver disease in Korean adults. Clinical Chemistry and Laboratory Medicine, 48(2), 175-80. https://doi.org/10.1515/CCLM.2010.037
Lee YJ, et al. Association Between Serum Uric Acid and Non-alcoholic Fatty Liver Disease in Korean Adults. Clin Chem Lab Med. 2010;48(2):175-80. PubMed PMID: 19961393.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between serum uric acid and non-alcoholic fatty liver disease in Korean adults. AU - Lee,Yong-Jae, AU - Lee,Hye-Ree, AU - Lee,Jung-Hyun, AU - Shin,Youn-Ho, AU - Shim,Jae-Yong, PY - 2009/12/8/entrez PY - 2009/12/8/pubmed PY - 2010/4/24/medline SP - 175 EP - 80 JF - Clinical chemistry and laboratory medicine JO - Clin Chem Lab Med VL - 48 IS - 2 N2 - BACKGROUND: Increased uric acid is associated with the metabolic syndrome, conditions linked to oxidative stress and insulin resistance. Non-alcoholic fatty liver disease (NAFLD) is now considered a hepatic manifestation of insulin resistance. However, little has been written regarding the association between uric acid and NAFLD. METHODS: We examined the association between uric acid and the presence of NAFLD in 3768 Koreans (2133 men, 1635 women; aged 20-75 years) in a health examination program. Uric acid quartiles were categorized separately as follows: Q1: <or=291.5, Q2: 291.6-333.1, Q3: 333.2-380.7, and Q4: >or=380.8 micromol/L for men; Q1: <or=202.2, Q2: 202.3-232.0, Q3: 231.1-267.7, and Q4: >or=267.8 micromol/L for women. Hepatic steatosis was diagnosed based on abdominal ultrasonographic findings by hyperechogenicity of liver tissue, difference of echogenicity between the liver and diaphragm, and visibility of vascular structures. The odds ratios (ORs) and 95% confidence intervals (CIs) for NAFLD were calculated across each quartile of serum uric acid. RESULTS: The prevalence of NAFLD was 25.8% (32.2% in men and 17.4% in women). After adjustment for age, body mass index (BMI), smoking, regular exercise, blood pressure, fasting plasma glucose (FPG), triglycerides, and high-density lipoprotein (HDL) cholesterol, the ORs (95% CIs) for NAFLD according to each quartile of uric acid were 1.00, 1.55 (1.13-2.14), 1.77 (1.30-2.41), and 2.01 (1.45-2.78) for men and 1.00, 0.69 (0.40-1.20), 1.12 (0.67-1.88), and 1.94 (1.21-3.13) for women. CONCLUSIONS: Serum uric acid is independently associated with the presence of NAFLD, and uric acid may be a useful additional measure in assessing the risk of NAFLD in the clinical setting. SN - 1437-4331 UR - https://www.unboundmedicine.com/medline/citation/19961393/Association_between_serum_uric_acid_and_non_alcoholic_fatty_liver_disease_in_Korean_adults_ L2 - https://www.degruyter.com/document/doi/10.1515/CCLM.2010.037 DB - PRIME DP - Unbound Medicine ER -