Tags

Type your tag names separated by a space and hit enter

Evidence for the involvement of the serotonergic 5-HT2A/C and 5-HT3 receptors in the antidepressant-like effect caused by oral administration of bis selenide in mice.
Prog Neuropsychopharmacol Biol Psychiatry. 2010 Mar 17; 34(2):294-302.PN

Abstract

The present study investigated a possible antidepressant-like activity of bis selenide using two predictive tests for antidepressant effect on rodents: the forced swimming test (FST) and the tail suspension test (TST). Bis selenide (0.5-5 mg/kg, p.o.) decreased the immobility time in the mouse FST and TST. The anti-immobility effect of bis selenide (1 mg/kg, p.o.) in the TST was prevented by the pretreatment of mice with p-chlorophenylalanine methyl ester (PCPA; 100 mg/kg, i.p., an inhibitor of serotonin synthesis), ketanserin (1 mg/kg, i.p., a 5-HT(2A/2C) receptor antagonist), and ondasentron (1 mg/kg, i.p., a 5-HT(3) receptor antagonist). Pretreatment of mice with prazosin (1 mg/kg, i.p., an alpha(1)-adrenoceptor antagonist), yohimbine (1 mg/kg, i.p., an alpha(2)-adrenoceptor antagonist), propranolol (2 mg/kg, i.p., a beta-adrenoceptor antagonist), SCH23390 (0.05 mg/kg, s.c., a dopamine D(1) receptor antagonist), sulpiride (50 mg/kg, i.p., a dopamine D(2) receptor antagonist), or WAY 100635 (0.1 mg/kg, s.c., a selective 5-HT(1A) receptor antagonist) did not block the antidepressant-like effect of bis selenide (1 mg/kg, p.o.) in the TST. Administration of bis selenide (0.1 mg/kg, p.o.) and fluoxetine (1 mg/kg), at subeffective doses, produced an antidepressant-like effect in the TST. Bis selenide did not alter Na(+) K(+) ATPase, MAO-A and MAO-B activities in whole brains of mice. Bis selenide produced an antidepressant-like effect in the mouse TST and FST, which may be related to the serotonergic system (5-HT(2A/2C) and 5-HT(3) receptors).

Authors+Show Affiliations

Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19961893

Citation

Jesse, Cristiano R., et al. "Evidence for the Involvement of the Serotonergic 5-HT2A/C and 5-HT3 Receptors in the Antidepressant-like Effect Caused By Oral Administration of Bis Selenide in Mice." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 34, no. 2, 2010, pp. 294-302.
Jesse CR, Wilhelm EA, Bortolatto CF, et al. Evidence for the involvement of the serotonergic 5-HT2A/C and 5-HT3 receptors in the antidepressant-like effect caused by oral administration of bis selenide in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(2):294-302.
Jesse, C. R., Wilhelm, E. A., Bortolatto, C. F., & Nogueira, C. W. (2010). Evidence for the involvement of the serotonergic 5-HT2A/C and 5-HT3 receptors in the antidepressant-like effect caused by oral administration of bis selenide in mice. Progress in Neuro-psychopharmacology & Biological Psychiatry, 34(2), 294-302. https://doi.org/10.1016/j.pnpbp.2009.11.023
Jesse CR, et al. Evidence for the Involvement of the Serotonergic 5-HT2A/C and 5-HT3 Receptors in the Antidepressant-like Effect Caused By Oral Administration of Bis Selenide in Mice. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Mar 17;34(2):294-302. PubMed PMID: 19961893.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence for the involvement of the serotonergic 5-HT2A/C and 5-HT3 receptors in the antidepressant-like effect caused by oral administration of bis selenide in mice. AU - Jesse,Cristiano R, AU - Wilhelm,Ethel A, AU - Bortolatto,Cristiani F, AU - Nogueira,Cristina W, Y1 - 2009/12/02/ PY - 2009/07/04/received PY - 2009/11/26/revised PY - 2009/11/26/accepted PY - 2009/12/8/entrez PY - 2009/12/8/pubmed PY - 2010/5/14/medline SP - 294 EP - 302 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog. Neuropsychopharmacol. Biol. Psychiatry VL - 34 IS - 2 N2 - The present study investigated a possible antidepressant-like activity of bis selenide using two predictive tests for antidepressant effect on rodents: the forced swimming test (FST) and the tail suspension test (TST). Bis selenide (0.5-5 mg/kg, p.o.) decreased the immobility time in the mouse FST and TST. The anti-immobility effect of bis selenide (1 mg/kg, p.o.) in the TST was prevented by the pretreatment of mice with p-chlorophenylalanine methyl ester (PCPA; 100 mg/kg, i.p., an inhibitor of serotonin synthesis), ketanserin (1 mg/kg, i.p., a 5-HT(2A/2C) receptor antagonist), and ondasentron (1 mg/kg, i.p., a 5-HT(3) receptor antagonist). Pretreatment of mice with prazosin (1 mg/kg, i.p., an alpha(1)-adrenoceptor antagonist), yohimbine (1 mg/kg, i.p., an alpha(2)-adrenoceptor antagonist), propranolol (2 mg/kg, i.p., a beta-adrenoceptor antagonist), SCH23390 (0.05 mg/kg, s.c., a dopamine D(1) receptor antagonist), sulpiride (50 mg/kg, i.p., a dopamine D(2) receptor antagonist), or WAY 100635 (0.1 mg/kg, s.c., a selective 5-HT(1A) receptor antagonist) did not block the antidepressant-like effect of bis selenide (1 mg/kg, p.o.) in the TST. Administration of bis selenide (0.1 mg/kg, p.o.) and fluoxetine (1 mg/kg), at subeffective doses, produced an antidepressant-like effect in the TST. Bis selenide did not alter Na(+) K(+) ATPase, MAO-A and MAO-B activities in whole brains of mice. Bis selenide produced an antidepressant-like effect in the mouse TST and FST, which may be related to the serotonergic system (5-HT(2A/2C) and 5-HT(3) receptors). SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/19961893/Evidence_for_the_involvement_of_the_serotonergic_5_HT2A/C_and_5_HT3_receptors_in_the_antidepressant_like_effect_caused_by_oral_administration_of_bis_selenide_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(09)00409-6 DB - PRIME DP - Unbound Medicine ER -