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Menopause is an independent predictor of metabolic syndrome in Iranian women.
Maturitas. 2010 Mar; 65(3):262-6.M

Abstract

BACKGROUND

Gender differences in prevalence and consequences of the metabolic syndrome as a strong predictor of cardiovascular disease (CVD), are challenging problems. Postmenopausal status may explain in part the cause of acceleration of CVD with aging. The purpose of this study was to investigate the relation of menopause and metabolic syndrome independent of aging among Iranian women.

METHODS

On the basis of consecutive recruitment, 940 women between 20 and 76 years old participated in the study. Anthropometric indices, fasting blood glucose, lipid profile were measured, Framingham risk score and homeostasis model assessment (HOMA-IR) were calculated for all participants. The metabolic syndrome (MetS) was defined according to the National Cholesterol Education Program Adult Treatment Panel III. We used IDF definition for metabolic syndrome modified by our recent local data as an alternative measurements.

RESULTS

The overall prevalence of metabolic syndrome was 26.4%. Its prevalence was 53.5% in postmenopausal versus 18.3% in premenopausal women. On binary logistic regression analysis, HOMA index, body mass index, waist to hip ratio, family history of diabetes and hypertension had an independent and significant effect on metabolic syndrome. Age-adjusted odds ratio (OR) of postmenopausal status for metabolic syndrome was 2.85 (95%CI: 1.31-6.20) (P<0.008). Framingham risk score was 8.3+/-7.7 in MetS+ve cases versus 1.9+/-2.1 in MetS-ve cases (P<0.001). There were significant differences between Framingham risk score in postmenopause 9.1+/-6.4 versus premenopause 1.6+/-1.6 (P<0.001). A significant correlation was found between Framingham risk score and body mass index, waist to hip ratio, HOMA-IR and components of metabolic syndrome (P<0.001). Forty percent of participants with premature menopause had metabolic syndrome versus 24% in age-matched group and Framingham risk score was significantly higher than normal cases 5.4+/-4.9 versus 2.0+/-2.3 (P<0.001).

CONCLUSION

Menopausal status can be a predictor of metabolic syndrome independent of age in Iranian women. Menopause is a process closely related to insulin resistance and cardiovascular risk factors.

Authors+Show Affiliations

AJA University of Medical Science, 3th Floor, Endocrine Research Center, Emam Reza Hospital (501-AJA), Etemad Zadeh Ave, Fatemi St, Tehran, Iran. r.eshtiaghi@gmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19962253

Citation

Eshtiaghi, Radina, et al. "Menopause Is an Independent Predictor of Metabolic Syndrome in Iranian Women." Maturitas, vol. 65, no. 3, 2010, pp. 262-6.
Eshtiaghi R, Esteghamati A, Nakhjavani M. Menopause is an independent predictor of metabolic syndrome in Iranian women. Maturitas. 2010;65(3):262-6.
Eshtiaghi, R., Esteghamati, A., & Nakhjavani, M. (2010). Menopause is an independent predictor of metabolic syndrome in Iranian women. Maturitas, 65(3), 262-6. https://doi.org/10.1016/j.maturitas.2009.11.004
Eshtiaghi R, Esteghamati A, Nakhjavani M. Menopause Is an Independent Predictor of Metabolic Syndrome in Iranian Women. Maturitas. 2010;65(3):262-6. PubMed PMID: 19962253.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Menopause is an independent predictor of metabolic syndrome in Iranian women. AU - Eshtiaghi,Radina, AU - Esteghamati,Alireza, AU - Nakhjavani,Manouchehr, Y1 - 2009/12/03/ PY - 2009/09/04/received PY - 2009/10/29/revised PY - 2009/11/02/accepted PY - 2009/12/8/entrez PY - 2009/12/8/pubmed PY - 2010/6/9/medline SP - 262 EP - 6 JF - Maturitas JO - Maturitas VL - 65 IS - 3 N2 - BACKGROUND: Gender differences in prevalence and consequences of the metabolic syndrome as a strong predictor of cardiovascular disease (CVD), are challenging problems. Postmenopausal status may explain in part the cause of acceleration of CVD with aging. The purpose of this study was to investigate the relation of menopause and metabolic syndrome independent of aging among Iranian women. METHODS: On the basis of consecutive recruitment, 940 women between 20 and 76 years old participated in the study. Anthropometric indices, fasting blood glucose, lipid profile were measured, Framingham risk score and homeostasis model assessment (HOMA-IR) were calculated for all participants. The metabolic syndrome (MetS) was defined according to the National Cholesterol Education Program Adult Treatment Panel III. We used IDF definition for metabolic syndrome modified by our recent local data as an alternative measurements. RESULTS: The overall prevalence of metabolic syndrome was 26.4%. Its prevalence was 53.5% in postmenopausal versus 18.3% in premenopausal women. On binary logistic regression analysis, HOMA index, body mass index, waist to hip ratio, family history of diabetes and hypertension had an independent and significant effect on metabolic syndrome. Age-adjusted odds ratio (OR) of postmenopausal status for metabolic syndrome was 2.85 (95%CI: 1.31-6.20) (P<0.008). Framingham risk score was 8.3+/-7.7 in MetS+ve cases versus 1.9+/-2.1 in MetS-ve cases (P<0.001). There were significant differences between Framingham risk score in postmenopause 9.1+/-6.4 versus premenopause 1.6+/-1.6 (P<0.001). A significant correlation was found between Framingham risk score and body mass index, waist to hip ratio, HOMA-IR and components of metabolic syndrome (P<0.001). Forty percent of participants with premature menopause had metabolic syndrome versus 24% in age-matched group and Framingham risk score was significantly higher than normal cases 5.4+/-4.9 versus 2.0+/-2.3 (P<0.001). CONCLUSION: Menopausal status can be a predictor of metabolic syndrome independent of age in Iranian women. Menopause is a process closely related to insulin resistance and cardiovascular risk factors. SN - 1873-4111 UR - https://www.unboundmedicine.com/medline/citation/19962253/Menopause_is_an_independent_predictor_of_metabolic_syndrome_in_Iranian_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5122(09)00403-4 DB - PRIME DP - Unbound Medicine ER -