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Sleep architecture and attenuated heart rate response to arousal from sleep in patients with autonomic failure.
Sleep Med. 2010 Jan; 11(1):87-92.SM

Abstract

OBJECTIVE

To determine if patients with autonomic failure have increased sleep disturbances and if multiple system atrophy (MSA) and pure autonomic failure (PAF) patients have frequent arousals from sleep associated with an attenuated heart rate (HR) response compared to healthy volunteers.

METHODS

With informed consent, 10 autonomic failure patients and 10 healthy volunteers were studied. Sleep disturbances were scored using standard criteria. Arousals were identified from stage 2 sleep and differences in the R-R interval between groups were tested using a mixed-model regression analysis.

RESULTS

Three MSA and one PAF patient had obstructive sleep apnoea compared to one volunteer. One MSA and three PAF patients had periodic limb movements. One MSA patient had REM behaviour disorder. The autonomic patients had significantly reduced total sleep time (p=0.007) and sleep efficiency (p=0.003). The HR response to arousal was smaller in autonomic failure patients compared to volunteers during the early phase of the arousal (p=0.047), but not the later phase (p=0.67).

CONCLUSION

Autonomic failure patients have increased sleep disturbances compared to healthy volunteers. The smaller HR response in autonomic failure patients suggests that an intact sympathetic nervous system is a key component of the HR response associated with arousal from sleep.

Authors+Show Affiliations

Clinical and Academic Unit of Sleep and Ventilation, Royal Brompton Hospital, Imperial College, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19962940

Citation

Freilich, Simon, et al. "Sleep Architecture and Attenuated Heart Rate Response to Arousal From Sleep in Patients With Autonomic Failure." Sleep Medicine, vol. 11, no. 1, 2010, pp. 87-92.
Freilich S, Goff EA, Malaweera AS, et al. Sleep architecture and attenuated heart rate response to arousal from sleep in patients with autonomic failure. Sleep Med. 2010;11(1):87-92.
Freilich, S., Goff, E. A., Malaweera, A. S., Twigg, G. L., Simonds, A. K., Mathias, C. J., & Morrell, M. J. (2010). Sleep architecture and attenuated heart rate response to arousal from sleep in patients with autonomic failure. Sleep Medicine, 11(1), 87-92. https://doi.org/10.1016/j.sleep.2008.12.017
Freilich S, et al. Sleep Architecture and Attenuated Heart Rate Response to Arousal From Sleep in Patients With Autonomic Failure. Sleep Med. 2010;11(1):87-92. PubMed PMID: 19962940.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sleep architecture and attenuated heart rate response to arousal from sleep in patients with autonomic failure. AU - Freilich,Simon, AU - Goff,Elizabeth A, AU - Malaweera,Anura S N, AU - Twigg,Gillian L, AU - Simonds,Anita K, AU - Mathias,Christopher J, AU - Morrell,Mary J, Y1 - 2009/12/04/ PY - 2008/10/07/received PY - 2008/12/08/revised PY - 2008/12/10/accepted PY - 2009/12/8/entrez PY - 2009/12/8/pubmed PY - 2010/5/15/medline SP - 87 EP - 92 JF - Sleep medicine JO - Sleep Med VL - 11 IS - 1 N2 - OBJECTIVE: To determine if patients with autonomic failure have increased sleep disturbances and if multiple system atrophy (MSA) and pure autonomic failure (PAF) patients have frequent arousals from sleep associated with an attenuated heart rate (HR) response compared to healthy volunteers. METHODS: With informed consent, 10 autonomic failure patients and 10 healthy volunteers were studied. Sleep disturbances were scored using standard criteria. Arousals were identified from stage 2 sleep and differences in the R-R interval between groups were tested using a mixed-model regression analysis. RESULTS: Three MSA and one PAF patient had obstructive sleep apnoea compared to one volunteer. One MSA and three PAF patients had periodic limb movements. One MSA patient had REM behaviour disorder. The autonomic patients had significantly reduced total sleep time (p=0.007) and sleep efficiency (p=0.003). The HR response to arousal was smaller in autonomic failure patients compared to volunteers during the early phase of the arousal (p=0.047), but not the later phase (p=0.67). CONCLUSION: Autonomic failure patients have increased sleep disturbances compared to healthy volunteers. The smaller HR response in autonomic failure patients suggests that an intact sympathetic nervous system is a key component of the HR response associated with arousal from sleep. SN - 1878-5506 UR - https://www.unboundmedicine.com/medline/citation/19962940/Sleep_architecture_and_attenuated_heart_rate_response_to_arousal_from_sleep_in_patients_with_autonomic_failure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1389-9457(09)00299-8 DB - PRIME DP - Unbound Medicine ER -