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Simulation of erythrocyte deformation in a high shear flow.
Conf Proc IEEE Eng Med Biol Soc 2009; 2009:2358-61CP

Abstract

Deformation of a red blood cell (RBC) in a high-shear flow was investigated. The RBC was modeled as a closed shell membrane consisting of spring networks in the framework of the energy minimum concept. The simulation of RBC in a parallel shear flow showed deformation parameters of RBC were well agreed with experimental results. The simulation of RBC behavior in various flow fields demonstrated that the shape was determined not only by instantaneous fluid force acting on it but also its deformation history. No consistency was found between the maximum of the first principal strain and conventionally used hemolysis index. Those results addressed the importance of considering an RBC deformation for accurately predicting hemolysis.

Authors+Show Affiliations

Center for Advanced Medical Engineering and Informatics, Osaka University, Toyonaka, Osaka 560-8531, Japan. masanori@me.es.osaka-u.ac.jpNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19965186

Citation

Nakamura, Masanori, et al. "Simulation of Erythrocyte Deformation in a High Shear Flow." Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, vol. 2009, 2009, pp. 2358-61.
Nakamura M, Bessho S, Wada S. Simulation of erythrocyte deformation in a high shear flow. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:2358-61.
Nakamura, M., Bessho, S., & Wada, S. (2009). Simulation of erythrocyte deformation in a high shear flow. Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2009, pp. 2358-61. doi:10.1109/IEMBS.2009.5335025.
Nakamura M, Bessho S, Wada S. Simulation of Erythrocyte Deformation in a High Shear Flow. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:2358-61. PubMed PMID: 19965186.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simulation of erythrocyte deformation in a high shear flow. AU - Nakamura,Masanori, AU - Bessho,Sadao, AU - Wada,Shigeo, PY - 2009/12/8/entrez PY - 2009/12/8/pubmed PY - 2010/3/17/medline SP - 2358 EP - 61 JF - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference JO - Conf Proc IEEE Eng Med Biol Soc VL - 2009 N2 - Deformation of a red blood cell (RBC) in a high-shear flow was investigated. The RBC was modeled as a closed shell membrane consisting of spring networks in the framework of the energy minimum concept. The simulation of RBC in a parallel shear flow showed deformation parameters of RBC were well agreed with experimental results. The simulation of RBC behavior in various flow fields demonstrated that the shape was determined not only by instantaneous fluid force acting on it but also its deformation history. No consistency was found between the maximum of the first principal strain and conventionally used hemolysis index. Those results addressed the importance of considering an RBC deformation for accurately predicting hemolysis. SN - 1557-170X UR - https://www.unboundmedicine.com/medline/citation/19965186/Simulation_of_erythrocyte_deformation_in_a_high_shear_flow_ L2 - https://dx.doi.org/10.1109/IEMBS.2009.5335025 DB - PRIME DP - Unbound Medicine ER -