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Neurobehavioral effects of cyclohexane in rat and human.
Int J Toxicol. 2009 Nov-Dec; 28(6):488-97.IJ

Abstract

The neurobehavioral effects of inhaled cyclohexane in rats and humans are investigated to define relationships between internal doses and acute central nervous system effects. Rats are exposed for 3 consecutive days at target concentrations of 0, 1.4, 8, and 28 g/m(3), 8 h/d. Measurements include standardized observational measures, spontaneous motor activity assessments, and learned visual discrimination performance. Cyclohexane concentrations in blood and brain are measured to assess internal exposure. Human volunteers are exposed for 4 hours to 86 or 860 mg/m(3) in 2 test sessions. Neurobehavioral effects are measured using a computerized neurobehavioral test battery. In rats, there are slight reductions in psychomotor speed in the high-exposure group but minimal central nervous system effects. In humans, there are no significant treatment-related effects at the levels tested.

Authors+Show Affiliations

TNO Quality of Life, Zeist, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19966141

Citation

Lammers, J H C M., et al. "Neurobehavioral Effects of Cyclohexane in Rat and Human." International Journal of Toxicology, vol. 28, no. 6, 2009, pp. 488-97.
Lammers JH, Emmen HH, Muijser H, et al. Neurobehavioral effects of cyclohexane in rat and human. Int J Toxicol. 2009;28(6):488-97.
Lammers, J. H., Emmen, H. H., Muijser, H., Hoogendijk, E. M., McKee, R. H., Owen, D. E., & Kulig, B. M. (2009). Neurobehavioral effects of cyclohexane in rat and human. International Journal of Toxicology, 28(6), 488-97. https://doi.org/10.1177/1091581809345534
Lammers JH, et al. Neurobehavioral Effects of Cyclohexane in Rat and Human. Int J Toxicol. 2009 Nov-Dec;28(6):488-97. PubMed PMID: 19966141.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurobehavioral effects of cyclohexane in rat and human. AU - Lammers,J H C M, AU - Emmen,H H, AU - Muijser,H, AU - Hoogendijk,E M G, AU - McKee,R H, AU - Owen,D E, AU - Kulig,B M, PY - 2009/12/8/entrez PY - 2009/12/8/pubmed PY - 2010/2/18/medline SP - 488 EP - 97 JF - International journal of toxicology JO - Int J Toxicol VL - 28 IS - 6 N2 - The neurobehavioral effects of inhaled cyclohexane in rats and humans are investigated to define relationships between internal doses and acute central nervous system effects. Rats are exposed for 3 consecutive days at target concentrations of 0, 1.4, 8, and 28 g/m(3), 8 h/d. Measurements include standardized observational measures, spontaneous motor activity assessments, and learned visual discrimination performance. Cyclohexane concentrations in blood and brain are measured to assess internal exposure. Human volunteers are exposed for 4 hours to 86 or 860 mg/m(3) in 2 test sessions. Neurobehavioral effects are measured using a computerized neurobehavioral test battery. In rats, there are slight reductions in psychomotor speed in the high-exposure group but minimal central nervous system effects. In humans, there are no significant treatment-related effects at the levels tested. SN - 1092-874X UR - https://www.unboundmedicine.com/medline/citation/19966141/Neurobehavioral_effects_of_cyclohexane_in_rat_and_human_ L2 - https://journals.sagepub.com/doi/10.1177/1091581809345534?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -