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Endocannabinoid signaling in neurotoxicity and neuroprotection.
Neurotoxicology 2010; 31(5):562-71N

Abstract

The cannabis plant and products produced from it, such as marijuana and hashish, have been used for centuries for their psychoactive properties. The mechanism for how Delta(9)-tetrahydrocannabinol (THC), the active constituent of cannabis, elicits these neurological effects remained elusive until relatively recently, when specific G-protein coupled receptors were discovered that appeared to mediate cellular actions of THC. Shortly after discovery of these specific receptors, endogenous ligands (endocannabinoids) were identified. Since that time, an extensive number of papers have been published on the endocannabinoid signaling system, a widespread neuromodulatory mechanism that influences neurotransmission throughout the nervous system. This paper summarizes presentations given at the 12th International Neurotoxicology Association meeting that described the potential role of endocannabinoids in the expression of neurotoxicity. Dr. Raphael Mechoulam first gave an overview of the discovery of exogenous and endogenous cannabinoids and their potential for neuroprotection in a variety of conditions. Dr. Larry Parsons then described studies suggesting that endocannabinoid signaling may play a selective role in drug reinforcement. Dr. Carey Pope presented information on the role that endocannabinoid signaling may have in the expression of cholinergic toxicity following anticholinesterase exposures. Together, these presentations highlighted the diverse types of neurological insults that may be modulated by endocannabinoids and drugs/toxicants which might influence endocannabinoid signaling pathways.

Authors+Show Affiliations

Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, USA. carey.pope@okstate.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

19969019

Citation

Pope, C, et al. "Endocannabinoid Signaling in Neurotoxicity and Neuroprotection." Neurotoxicology, vol. 31, no. 5, 2010, pp. 562-71.
Pope C, Mechoulam R, Parsons L. Endocannabinoid signaling in neurotoxicity and neuroprotection. Neurotoxicology. 2010;31(5):562-71.
Pope, C., Mechoulam, R., & Parsons, L. (2010). Endocannabinoid signaling in neurotoxicity and neuroprotection. Neurotoxicology, 31(5), pp. 562-71. doi:10.1016/j.neuro.2009.12.002.
Pope C, Mechoulam R, Parsons L. Endocannabinoid Signaling in Neurotoxicity and Neuroprotection. Neurotoxicology. 2010;31(5):562-71. PubMed PMID: 19969019.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endocannabinoid signaling in neurotoxicity and neuroprotection. AU - Pope,C, AU - Mechoulam,R, AU - Parsons,L, Y1 - 2009/12/05/ PY - 2009/09/02/received PY - 2009/12/02/accepted PY - 2009/12/9/entrez PY - 2009/12/9/pubmed PY - 2010/12/22/medline SP - 562 EP - 71 JF - Neurotoxicology JO - Neurotoxicology VL - 31 IS - 5 N2 - The cannabis plant and products produced from it, such as marijuana and hashish, have been used for centuries for their psychoactive properties. The mechanism for how Delta(9)-tetrahydrocannabinol (THC), the active constituent of cannabis, elicits these neurological effects remained elusive until relatively recently, when specific G-protein coupled receptors were discovered that appeared to mediate cellular actions of THC. Shortly after discovery of these specific receptors, endogenous ligands (endocannabinoids) were identified. Since that time, an extensive number of papers have been published on the endocannabinoid signaling system, a widespread neuromodulatory mechanism that influences neurotransmission throughout the nervous system. This paper summarizes presentations given at the 12th International Neurotoxicology Association meeting that described the potential role of endocannabinoids in the expression of neurotoxicity. Dr. Raphael Mechoulam first gave an overview of the discovery of exogenous and endogenous cannabinoids and their potential for neuroprotection in a variety of conditions. Dr. Larry Parsons then described studies suggesting that endocannabinoid signaling may play a selective role in drug reinforcement. Dr. Carey Pope presented information on the role that endocannabinoid signaling may have in the expression of cholinergic toxicity following anticholinesterase exposures. Together, these presentations highlighted the diverse types of neurological insults that may be modulated by endocannabinoids and drugs/toxicants which might influence endocannabinoid signaling pathways. SN - 1872-9711 UR - https://www.unboundmedicine.com/medline/citation/19969019/Endocannabinoid_signaling_in_neurotoxicity_and_neuroprotection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-813X(09)00274-5 DB - PRIME DP - Unbound Medicine ER -