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Increased rate of whole body lipolysis before and after 9 days of bed rest in healthy young men born with low birth weight.
Am J Physiol Endocrinol Metab. 2010 Mar; 298(3):E555-64.AJ

Abstract

Individuals born with low birth weight (LBW) are at risk of developing type 2 diabetes mellitus (T2D), which may be precipitated by physical inactivity. Twenty-two LBW subjects and twenty-three controls were studied before and after bed rest by the hyperinsulinemic euglycemic clamp combined with indirect calorimetry and infusion of stable isotope tracers and preceded by an intravenous glucose tolerance test. LBW subjects had a similar body mass index but elevated abdominal obesity compared with controls. The basal rate of whole body lipolysis (WBL) was elevated in LBW subjects with and without correction for abdominal obesity before and after bed rest (all P = 0.01). Skeletal muscle hormone-sensitive lipase (HSL) protein expression and phosphorylation at Ser565 were similar in the two groups. Bed rest resulted in a decrease in WBL and an increased skeletal muscle HSL Ser565 phosphorylation indicating a decreased HSL activity in both groups. All subjects developed peripheral insulin resistance in response to bed rest (all P < 0.0001) with no differences between groups. LBW subjects developed hepatic insulin resistance in response to bed rest. In conclusion, increased WBL may contribute to the development of hepatic insulin resistance when exposed to bed rest in LBW subjects. Nine days of bed rest causes severe peripheral insulin resistance and reduced WBL and skeletal muscle HSL activity, as well as a compensatory increased insulin secretion, with no differences in LBW subjects and controls.

Authors+Show Affiliations

Steno Diabetes Centre, Gentofte, Denmark. aagv@steno.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19996383

Citation

Alibegovic, A C., et al. "Increased Rate of Whole Body Lipolysis Before and After 9 Days of Bed Rest in Healthy Young Men Born With Low Birth Weight." American Journal of Physiology. Endocrinology and Metabolism, vol. 298, no. 3, 2010, pp. E555-64.
Alibegovic AC, Højbjerre L, Sonne MP, et al. Increased rate of whole body lipolysis before and after 9 days of bed rest in healthy young men born with low birth weight. Am J Physiol Endocrinol Metab. 2010;298(3):E555-64.
Alibegovic, A. C., Højbjerre, L., Sonne, M. P., van Hall, G., Alsted, T. J., Kiens, B., Stallknecht, B., Dela, F., & Vaag, A. (2010). Increased rate of whole body lipolysis before and after 9 days of bed rest in healthy young men born with low birth weight. American Journal of Physiology. Endocrinology and Metabolism, 298(3), E555-64. https://doi.org/10.1152/ajpendo.00223.2009
Alibegovic AC, et al. Increased Rate of Whole Body Lipolysis Before and After 9 Days of Bed Rest in Healthy Young Men Born With Low Birth Weight. Am J Physiol Endocrinol Metab. 2010;298(3):E555-64. PubMed PMID: 19996383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased rate of whole body lipolysis before and after 9 days of bed rest in healthy young men born with low birth weight. AU - Alibegovic,A C, AU - Højbjerre,L, AU - Sonne,M P, AU - van Hall,G, AU - Alsted,T J, AU - Kiens,B, AU - Stallknecht,B, AU - Dela,F, AU - Vaag,A, Y1 - 2009/12/08/ PY - 2009/12/10/entrez PY - 2009/12/10/pubmed PY - 2010/3/31/medline SP - E555 EP - 64 JF - American journal of physiology. Endocrinology and metabolism JO - Am J Physiol Endocrinol Metab VL - 298 IS - 3 N2 - Individuals born with low birth weight (LBW) are at risk of developing type 2 diabetes mellitus (T2D), which may be precipitated by physical inactivity. Twenty-two LBW subjects and twenty-three controls were studied before and after bed rest by the hyperinsulinemic euglycemic clamp combined with indirect calorimetry and infusion of stable isotope tracers and preceded by an intravenous glucose tolerance test. LBW subjects had a similar body mass index but elevated abdominal obesity compared with controls. The basal rate of whole body lipolysis (WBL) was elevated in LBW subjects with and without correction for abdominal obesity before and after bed rest (all P = 0.01). Skeletal muscle hormone-sensitive lipase (HSL) protein expression and phosphorylation at Ser565 were similar in the two groups. Bed rest resulted in a decrease in WBL and an increased skeletal muscle HSL Ser565 phosphorylation indicating a decreased HSL activity in both groups. All subjects developed peripheral insulin resistance in response to bed rest (all P < 0.0001) with no differences between groups. LBW subjects developed hepatic insulin resistance in response to bed rest. In conclusion, increased WBL may contribute to the development of hepatic insulin resistance when exposed to bed rest in LBW subjects. Nine days of bed rest causes severe peripheral insulin resistance and reduced WBL and skeletal muscle HSL activity, as well as a compensatory increased insulin secretion, with no differences in LBW subjects and controls. SN - 1522-1555 UR - https://www.unboundmedicine.com/medline/citation/19996383/Increased_rate_of_whole_body_lipolysis_before_and_after_9_days_of_bed_rest_in_healthy_young_men_born_with_low_birth_weight_ DB - PRIME DP - Unbound Medicine ER -